Human Papillomavirus Infection of the Skin

Bacaj, Patrick; Burch, David

doi:10.5858/arpa.2017-0572-ra

Cited by 30 publications

(39 citation statements)

References 31 publications

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“…However, some limitations exist regarding the current study. Although only common warts (Verruca vulgaris) were investigated, HPV-induced warts are heterogeneous in nature, and several different HPV types have been associated with common warts, including HPV 2, 4, 7, 27, and 57 [43]. In addition, the HPV genome is itself highly heterogenous due to the fact that each HPV type has evolved to maximize viral fitness to its biological ecosystem within the host, i.e.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of HPV-induced warts and healthy skin in humans

et al. 2020

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Background: The human papillomaviruses (HPV) are a group of viruses that, depending on the strain, can cause cancer or the formation of benign growths known as warts. Scarce information exists with regard to the genetic nature of non-genital cutaneous warts induced by the human papillomavirus (HPV). Methods: The main purpose of this study is to investigate the differences between the gene expression profiles of common warts and healthy skin in HPV-positive individuals by RNA sequencing on the Illumina HiSeq 2500. After obtaining shave biopsies of common warts and healthy skin from twelve Arab males, we were able to analyze the transcriptomes of 24 paired cases and controls. Results: Common warts were found to possess a highly significant and unique molecular signature. Many of the most up-regulated (KRT16, EPGN, and ABCG4) and down-regulated genes (C15orf59, CYB561A3, and FCGRT) in warts were the subject of little investigation in the published literature. Moreover, the top 500 differentially expressed genes were found to be associated with immune and autoimmune pathways, such as the neutrophil degranulation, toll-like receptor 7/8 (TLR 7/8) cascade, toll-like receptor 9 (TLR9) cascade, and toll-like receptor 10 (TLR10) pathways, among others. Conclusions: Our findings are particularly important because they serve as the most comprehensive to date with regard to the modulation of human skin gene expression by HPV infection.

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Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of HPV-induced warts and healthy skin in humans

et al. 2020

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“…Common warts, also referred to as Verruca vulgaris, are the most prevalent type of wart, constituting around 70% of all non-genital cutaneous warts [9,10]. The wart itself is formed after HPV gains access to the basal layer of the epidermis via a microabrasion in the skin and induces the rapid growth and proliferation of keratinocyte cells [11]. In immunocompetent individuals, HPV-induced warts are self-limiting, as the virus is usually cleared from the body in a period of one to two years [12].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Tiling Array Analysis of HPV-Induced Warts Reveals Aberrant Methylation of Protein-Coding and Non-Coding Regions

AL-Eitan

Alghamdi

Tarkhan

et al. 2019

Genes

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The human papillomaviruses (HPV) are a group of double-stranded DNA viruses that exhibit an exclusive tropism for squamous epithelia. HPV can either be low- or high-risk depending on its ability to cause benign lesions or cancer, respectively. Unsurprisingly, the majority of epigenetic research has focused on the high-risk HPV types, neglecting the low-risk types in the process. Therefore, the main objective of this study is to better understand the epigenetics of wart formation by investigating the differences in methylation between HPV-induced cutaneous warts and normal skin. A number of clear and very significant differences in methylation patterns were found between cutaneous warts and normal skin. Around 55% of the top-ranking 100 differentially methylated genes in warts were protein coding, including the EXOC4, KCNU, RTN1, LGI1, IRF2, and NRG1 genes. Additionally, non-coding RNA genes, such as the AZIN1-AS1, LINC02008, and MGC27382 genes, constituted 11% of the top-ranking 100 differentially methylated genes. Warts exhibited a unique pattern of methylation that is a possible explanation for their transient nature. Since the genetics of cutaneous wart formation are not completely known, the findings of the present study could contribute to a better understanding of how HPV infection modulates host methylation to give rise to warts in the skin.

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“…HPV human papillomavirus is circular, double strand DNA viruses with genome size 8 Kb have eight proteins-coding genes including L1, L2 gene (which coding for the capsid proteins or structural proteins) E genes including E 1,2,4,5,6,7 coding for proteins which responsible for viral replication, transcription and transformation 4 . HPV belong to Papillomaviridea and over 130 different kind has been classified according to variation in L1 gene 5 HPV transmitted directly through skin to skin contact either in children or through the sexual rote infect skin cells and cause benign or malignant wart or skin lesions 6 .…”

Section: Introductionmentioning

confidence: 99%

“…HPV belong to Papillomaviridea and over 130 different kind has been classified according to variation in L1 gene 5 HPV transmitted directly through skin to skin contact either in children or through the sexual rote infect skin cells and cause benign or malignant wart or skin lesions 6 . The life cycle of HPV starting by entry of impaired skin barrier and infect the basal squamous cells and stimulate the epidermal cell proliferation, some of the viral proteins suppress some mechanisms that control the cell cycle, E6 protein bind to P53 protein, interfere with its function and stimulate its degradation 7 .…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of P53 Polymorphism in Susceptibility to Human Papillomavirus and Molluscum contagiosum Infections

Mughir¹,

Ibraheam²,

Al-Murshidi³

2019

J Pure Appl Microbiol

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P53 is Tumor suppressor gene which plays a main role in the genomic integrity preservation, mutation in this gene may change the susceptibility of individuals for several viral infections. This work designed to evaluate the effectiveness of P53 gene polymorphism (Arg/Pro) in susceptibility to infection with Molluscum contagiosum and Human Papillomavirus. Thirty one (31) invasive Molluscum contagiosum and 31 invasive Human Papillomavirus cases were studied and compared with 31 matched controls. Striking increase in (Arg/ Arg) and (Arg/ Pro) and decrease of (Pro/ Pro) genotype frequencies have been observed in MCV and HPV infected patients, by comparing with controls, we didn't find significant relation between this infection and P53 genotypes. By investigate the frequency of mutation (Pro/ Pro vs. Arg/ Arg and Arg/ Pro) we found significant increasing of (Arg/ Arg) and (Arg/ Pro) in MCV infected patients p=0.023<0.05.we found that the carrying of Arg allele be more susceptible to infect with MCV and HPV while Pro/Pro genotype may confer protection against this viruses in our population.

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Human Papillomavirus Infection of the Skin

Cited by 30 publications

References 31 publications

Transcriptome analysis of HPV-induced warts and healthy skin in humans

Transcriptome analysis of HPV-induced warts and healthy skin in humans

Genome-Wide Tiling Array Analysis of HPV-Induced Warts Reveals Aberrant Methylation of Protein-Coding and Non-Coding Regions

The Effectiveness of P53 Polymorphism in Susceptibility to Human Papillomavirus and Molluscum contagiosum Infections

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