Human papillomavirus infection is associated with decreased levels of GM-CSF in cervico-vaginal fluid of infected women

Comar, Manola; Monasta, Lorenzo; Zanotta, Nunzia; Brumatti, Liza Vecchi; Ricci, Giuseppe; Zauli, Giorgio

doi:10.1016/j.jcv.2013.07.001

Cited by 19 publications

(32 citation statements)

References 10 publications

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“…The main characteristics of included studies are described in Table 1. Twelve studies [12, 19-22, 24-30] reported the impact of HPV infection on risk of spontaneous abortion. Five studies [17, 18, 21, 23, 31] reported the risk of sPTB and 7 studies [10-12, 19-22] reported the risk of clinical pregnancy rate of ART.…”

Section: Resultsmentioning

confidence: 99%

The Risk of Human Papillomavirus Infection for Spontaneous Abortion, Spontaneous Preterm Birth, and Pregnancy Rate of Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis

Xiong

Luo

et al. 2018

Gynecol Obstet Invest

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Aims: To estimate the impact of human papillomavirus (HPV) infection on spontaneous abortion, spontaneous preterm birth (sPTB), pregnancy rate of females undergoing assisted reproductive technologies (ART), and spontaneous abortion of ART pregnancy. Methods: PubMed, Medline, Embase, and the Cochrane Library were searched until December 16, 2016. The OR or relative risk (RR) with its corresponding 95% CI were selected as effect size. Subgroup analysis of HPV genotype infection (high-risk HPV [HR-HPV] or indiscriminate genotype) was performed. Statistical analysis was conducted using STATA 12.0. Results: Eighteen studies were included. Eight studies revealed no significant association between HPV infection and spontaneous abortion (OR 1.40, 95% CI 0.56–3.50). However, subgroup analysis showed indiscriminate genotype HPV infection increased the ratio of spontaneous abortion with OR of 2.24 (95% CI 1.37–3.65), while HR-HPV infection had no significant effect (OR 0.65, 95% CI 0.21–1.98). The results indicated that HR-HPV infection was a risk for sPTB with a pooled OR of 2.84 (95% CI 1.95–4.14). HPV infection was found to be independent of the ART-based clinical pregnancy rate (RR 1.04, 95% CI 0.64–1.70) and spontaneous abortion of ART pregnancy (RR 1.47, 95% CI 0.86–2.50). Conclusions: Indiscriminate HPV genotype infection can increase the risk of spontaneous abortion and HR-HPV infection was a risk factor for sPTB. However, there was not enough evidence to indicate the association between HPV infection and pregnancy rate of ART, and spontaneous abortion of ART pregnancy. Different genotypes of HPV infection may play a discrepant role in adverse pregnancy outcomes.

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Section: Resultsmentioning

confidence: 99%

The Risk of Human Papillomavirus Infection for Spontaneous Abortion, Spontaneous Preterm Birth, and Pregnancy Rate of Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis

Xiong

Luo

et al. 2018

Gynecol Obstet Invest

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“…After the removal of 10 records as duplicates and screening of 92 through their abstracts, 38 studies were identified as possibly eligible for inclusion and retrieved as full texts. Of these, 24 studies were excluded (Table S1), two studies were ongoing 15,16 , two of those eligible were not used in the meta-analysis owing to a lack of data of interest 17,18 and 10 that met the qualitative and quantitative criteria for inclusion in our meta-analysis were selected 6,7,[19][20][21][22][23][24][25][26] (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Concerning the primary outcomes of the study, there was no evidence of a difference when comparing HPV-positive (HPV+) women with HPV-negative (HPV-) women regarding live birth or ongoing pregnancy (RR, 1.16 (95% CI, 0.88-1.53); six studies, 983 participants; I 2 = 0%, very low-quality evidence) 6,[20][21][22][23][24] and rate of miscarriage per clinical pregnancy (RR, 1.58 (95% CI, 0.93-2.69); six studies, 290 participants; I 2 = 8%, very low-quality evidence) 6,[20][21][22][23][24] (Tables 1, 2 and Figure 2). Concerning the secondary outcomes of the study, there was no evidence of a difference when comparing HPV+ women with HPV-women regarding clinical pregnancy (RR, 1.06 (95% CI, 0.74-1.54); eight studies, 1173 participants; I 2 = 61%, very low-quality evidence) 6,7,[19][20][21][22][23][24] , positive pregnancy test (RR, 0.90 (95% CI, 0.62-1.30); six studies, 1464 participants; I 2 = 57%, very low-quality evidence) 7,[19][20][21]24,26 and ectopic pregnancy rate (RR, 0.54 (95% CI, 0.12-2.48); two studies, 148 participants; I 2 = 0%, very low-quality evidence) 21,24 (Tables 1, 2 and Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Concerning the secondary outcomes of the study, there was no evidence of a difference when comparing HPV+ women with HPV-women regarding clinical pregnancy (RR, 1.06 (95% CI, 0.74-1.54); eight studies, 1173 participants; I 2 = 61%, very low-quality evidence) 6,7,[19][20][21][22][23][24] , positive pregnancy test (RR, 0.90 (95% CI, 0.62-1.30); six studies, 1464 participants; I 2 = 57%, very low-quality evidence) 7,[19][20][21]24,26 and ectopic pregnancy rate (RR, 0.54 (95% CI, 0.12-2.48); two studies, 148 participants; I 2 = 0%, very low-quality evidence) 21,24 (Tables 1, 2 and Figure 2). There were no data available to perform an analysis for the other outcomes preset for this review.…”

Section: Resultsmentioning

confidence: 99%

“…Concerning the subgroup analyses, only data on the presence of infection in the male partner were available and analyzed: there was evidence of a difference Study or subgroup Comar (2013) 20 Kulp (2007) 21 Oborna (2016) 22 Perino (2011) 6 Tanaka (2000) 23 Yang (2013) 24 Total (95% CI) Total events Heterogeneity: tau 2 = 0.00; chi 2 = 4.60, df = 5 (P = 0.47); I 2 = 0% Test for overall effect: Z = 1.05 (P = 0.29) 20 Kulp (2007) 21 Oborna (2016) 22 Perino (2011) 6 Tanaka (2000) 23 Yang (2013) 24 Total (95% CI) Total events Heterogeneity: tau 2 = 0.04; chi 2 = 5.46, df = 5 (P = 0.36); I 2 = 8% Test for overall effect: Z = 1.70 (P = 0.09) 19 Comar (2013) 20 Kulp (2007) 21 Oborna (2016) 22 Perino (2011) 6 Spandorfer (2006) 7 Tanaka (2000) 23 Yang (2013) 24 Total (95% CI) Total events Heterogeneity: tau 2 = 0.15; chi 2 = 17.95, df = 7 (P = 0.01); I 2 = 61% Test for overall effect: Z = 0.33 (P = 0.74) 2 2 11 18 15 4 5 19 76 13 12 20 45 35 17 10 56 208 38 11 8 88 51 46 39 23 304 71 70 16 317 164 89 182 when comparing HPV+ with HPV-male participants regarding live birth or ongoing pregnancy (RR, 0.43 (95% CI, 0.23-0.82); three studies, 429 participants; I 2 = 0%, P = 0.01, very low-quality evidence) 6,23,27 , and miscarriage rates per clinical pregnancy (RR, 3.7...…”

Section: Resultsmentioning

confidence: 99%

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Effect of human papilloma virus infection onin‐vitrofertilization outcome: systematic review and meta‐analysis

Siristatidis

Vaidakis

Sertedaki

et al. 2018

Ultrasound in Obstet & Gyne

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The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review

Das

Fletcher

et al. 2023

Journal of Medical Virology

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It is believed that human papilloma virus infection (HPV), which is caused by the DNA virus, is the most prominent factor contributing to sexually transmitted disease (STD) in the world, with males having a prevalence rate of 3.5%-45% while that women are 2%-44%. Infertility is a rising problem on a global basis, affecting anywhere from 10% to 30% of couples who have reached reproductive age. This study aims to investigate the existing research on HPV, its connection to male infertility, and how it could be a helpful tool for medical professionals managing HPV in the context of reproductive health care. Infection with HPV has been identified as a risk factor for several spontaneous abortions; however, there is a lack of evidence on how HPV influences individuals undergoing assisted reproductive technology (ART) in terms of live births. The significance of the immune response to HPVinfected male reproductive system cells and its effect on embryos, as well as the oxidative stress generated by high-risk HPV DNA damage and genomic instability, is discussed in this review. Further, the association between male individuals infected with HPV and asthenozoospermia should provide a compelling case for vaccinating young people against HPV.

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Human papillomavirus infection is associated with decreased levels of GM-CSF in cervico-vaginal fluid of infected women

Cited by 19 publications

References 10 publications

The Risk of Human Papillomavirus Infection for Spontaneous Abortion, Spontaneous Preterm Birth, and Pregnancy Rate of Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis

The Risk of Human Papillomavirus Infection for Spontaneous Abortion, Spontaneous Preterm Birth, and Pregnancy Rate of Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis

Effect of human papilloma virus infection onin‐vitrofertilization outcome: systematic review and meta‐analysis

The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review

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