Human papillomavirus infection in women with and without cervical cancer in Tehran, Iran

Abstract

No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in Iran or the Middle East. Cervical specimens were obtained from 825 married women aged 18-59 years from the general population of Tehran, Iran and from 45 locally diagnosed invasive cervical cancers (ICC) according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV was detected and genotyped using a GP5+/6+ PCR-based assay. HPV prevalence in the general population was 7.8% (95% confidence interval: 6.0-9.8) (5.1% of high-risk types), with no significant variation by age. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's absence from home for >7 nights/month. HPV16/18 accounted for 30 and 82.2% of HPV-positive women in the general population and ICC, respectively. Cervical cancer prevention policies should take into account the relatively low HPV prevalence in this population.

Prevalence of Human Papilloma Virus Types 16 and 18 Among Women With Cervical Cancer in Aleppo, Syria

“…These incidence rates differ from the rates reported by Darnel et al [10] which were 47.7% and 40.9% for HPV 16 and HPV 18 respectively. However, the distribution of these two HPV types in our study is quite similar to a report from Iran which showed HPV 16 and HPV18 prevalence of 60% and 22.2% respectively [23]. Similarly, the most prevalent HPV types found in a study from India were HPV 16 (66.7%) followed by HPV 18 (19.4%) [24].…”

Human Papilloma Virus Frequency and Genotype Distribution in a Turkish Population

“…Yuce et al (2012) reported HPV prevalence as 25.7 (Yuce et al, 2012) and Eroglu detected a positive rate of 32.5% in Kayseri (Eroglu et al, 2011). Studies from different countries which have all used PCR based methods report rates as 7.8% in Iran (Khodakarami et al, 2012), 10.3% in India (Sauvaget et al, 2011), 19.4% in Portugal (Pista et al, 2011, 35.9% in Italy (Piana et al, 2011) and 64.1% in France (Casalegno et al, 2011). There is a wide range between HPV prevalence rates.…”

Human Papillomavirus 45 Genetic Variation and Cervical Cancer Risk Worldwide

“…The IARC has coordinated cervical cancer case series, cervical cancer case-control studies, and population-based HPV prevalence surveys in a large number of countries around the world (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35); also as-yet-unpublished studies from Fiji and Bhutan). The collection of samples has spanned a period of over 20 years from 1989 until 2012 and predates the introduction of HPV vaccines.…”