Human papillomavirus infection in the etiology of laryngeal carcinoma

Hobbs, Christopher; Birchall, Martin A.

doi:10.1097/00020840-200404000-00006

Cited by 40 publications

(37 citation statements)

References 29 publications

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“…[29][30][31] Our results suggest that the onset and progression of HPV-positive carcinomas is indeed distinguishable from their HPV-negative counterparts, particularly in regards to their lack of connection to past tobacco use and earlier onset, while our data are compatible with a possibly better prognosis in terms of recurrence. Similar to other studies, [5][6][7] HPV-16, known to be associated with malignancy, was the most common type detected in positive cases (33.3%). Despite the fact that HPV-6 and -11 are among the most commonly detected types of HPV, neither was found in the laryngeal carcinomas sampled, confirming the role of these two viral types as precursors of mostly benign papillomas rather than malignancies.…”

Section: Discussionsupporting

confidence: 88%

“…4 Earlier studies demonstrated that HPV-16 is the most widely detected viral type in cancerous lesions of the larynx, although the reported incidence of HPV varied widely. [5][6][7] Differences in detection methods may account for these inconsistencies, and since most of the assay systems employed were capable of detecting only the most common high-risk HPV types (16,18,31,33, and 45), estimates of incidence may have been conservative. In addition to high-risk HPV as a risk factor for laryngeal malignancies, the presence of low-risk HPV types 6 and 11 has been associated with recurrent respiratory papillomatosis (RRP), which may present with an indolent or aggressive, even life-threatening growth of benign papillomas in the larynx and the airway.…”

Section: Introductionmentioning

confidence: 99%

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Human papillomavirus in early laryngeal carcinoma

et al. 2009

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Human papillomavirus in early laryngeal carcinoma

et al. 2009

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“…Recurrent respiratory papillomas (RRP) represent the most common benign tumor of the larynx, in adults it constitutes about 10% of all laryngeal tumors or about 87% of all benign laryngeal tumors [1][2][3]. The incidence of RRP in the United States is estimated at 4.0-4.3 per 100,000 in children and 1.8-2.0 per 100,000 in adults, 0.24 per 100,000 in children aged 14 years and younger in Canada, and overall incidence at 3.84 cases per 100,000 in Denmark [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Expression of matrix metalloproteinases (MMP-2 and MMP-9) in recurrent respiratory papillomas and laryngeal carcinoma: clinical and morphological parallels

Uloza¹,

Liutkevičius²,

Pangonytė

et al. 2011

Eur Arch Otorhinolaryngol

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The task of the present study was to investigate the expression of MMP-2 and MMP-9 in recurrent respiratory papillomas (RRP) and accomplish a comparative analysis with those in laryngeal squamous cell carcinoma (LSCC). The immunohistochemical expression of MMP-2 and MMP-9 was investigated in specimens taken from RRP (n = 38) and LSCC (n = 39) patient groups, and the normal tissue of vocal fold (n = 12, control group). The expression of MMP-2 and MMP-9, both in epithelium and stroma cells, was graded on a semiquantitative scale, ranging from 0 (no expression) to 18 points (high expression). Statistically significant differences in the expression of MMP-2 and MMP-9, both in epithelium and stroma among the RRP, LSCC patients and control group (epithelium) with the LSCC group having the highest MMPs expression scores were revealed. However, no statistically significant correlations among expression of MMPs and clinical and/or morphological features were found in the group of RRP patients. The MMP-2 stroma value of 10.4 points was determined as the optimum point (limiting value) for separating RRP and LSCC patient groups. Results of the present study indicate that the expression of both MMP-2 and MMP-9 are up-regulated early in development of laryngeal papillomas, when the benign neoplastic lesion begins and the next determinant step is concerned with the occurrence of malignization. These results seem promising, as they may improve our understanding of the molecular events leading to the papilloma formation and development, however, further research is needed.

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“…[6][7][8] Fol lo wing HPV scre e ning, the HPV-po siti ve samp les we re sub mit ted for ge noty ping. The pre vi o usly des cri bed GP-E6/E7 ge noty ping stra tegy, ba sed on MPCR pro duct si ze, was used for HPV ge noty ping.…”

Section: Dna Ex Trac Ti On and Mul Tip Lex Poly Me Ra Se Cha -In Re Amentioning

confidence: 99%

Human Papilloma Virus Prevalence in Hyperplastic Tonsils and Adenoids in Children and Young Adults

Baloğlu¹,

Küçükodacı²,

Güngör³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Our aim was to determine HPV prevalence and genotypes in nontumoral tonsillar and/or adenoid tissue in young adults to open a discussion about the rationale of HPV detection in tonsil and adenoid tissues because of the cancer development risk. M Ma at te er ri ia al l a an nd d M Me et th h--o od ds s: : Archived resection materials of 258 patients treated between 2003 and 2007 were retrieved for HPV detection and typing. Sections of formalin-fixed, paraffin-blocked tissue samples of each resected material were used as the DNA source. Six patients were excluded because of the inadequate quality of the extracted DNA. The age range of the remaining 252 patients was between 5 and 21 years (11.94 ± 4.20). After PCR screening, four different sets of primers covering 18 HPV types were used for HPV genotyping by multiplex polymerase chain reaction (MPCR). R Re es su ul lt ts s: : Sixteen of the 252 surgical samples, namely nine of 114 tonsillectomies (7.9%), four of 87 adenoidectomies (4.6%), and 3 of 51 adenotonsillectomy tissues (5.9%) were found to contain the HPV genome (6.3%). Genotypes revealed that HPV-16 was the dominant genotype, found in 11 cases, followed by HPV-6/11 in four cases, and HPV-31 in one case. C Co on nc cl lu us si io on n: : The prevalence of HPV in children and young adults that suffered from upper airway obstruction due to nontumoral tonsil and/or adenoid overgrowth was found to be 6.3% in our study. This study reveals the need for further molecular assists for HPV under the light of 6.3 % of detected HPV prevalence and the high risk HPV type 16 predominance. Since the oncogenic risk, we strongly suggest evaluation of HPV in tonsillectomy and adenoidectomy material similar to oropharyngeal squamous etithelium. K Ke ey y W Wo or rd ds s: : Human papillomavirus 16; tonsillectomy; adenoids Ö ÖZ ZE ET T A Am ma aç ç: : Amacımız, genç erişkinlerde tümöral olmayan tonsil ve adenoid dokusunda kanser gelişme riskinden dolayı human papilloma virüs (HPV) taranmasının mantığına açıklık getirmek için tümöral olmayan tonsil ve adenoid dokusunda HPV sıklığı ve genotipini saptamaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : 2003-2007 yılları arasında tedavi olmuş 258 hastanın arşiv materyallerinde HPV taraması ve tiplendirilmesi yapıldı. DNA kaynağı olarak, her bir rezeksiyon materyalinin formalinde fikse, parafin bloklu doku örnek kesitleri kullanıldı. Ekstrakte edilen DNA kalitesinin yeterli olmayışı nedeniyle altı hasta çalışma dışı bırakıldı. Kalan 252 hasta 5-21 (11.94 ± 4.20) yaşları arasındaydı. Tarama polimeraz zincir reaksiyon (PCR)'larından sonra, 18 HPV tipini kapsayan dört farklı primer seti kullanılarak multiplex polymerase chain reaction (MPCR) ile HPV genotiplemesi yapıldı. B Bu ul lg gu ul la ar r: : Yüz ön dört tonsillektominin dokuzu (%7.9), 87 adenoidektominin dördü (%4.6) ve 51 adenotonsillektominin üçü (%5.9) olmak üzere toplam 252 cerrahi örneğin 16'sında (%6.3) HPV genomu varlığı tespit edildi. En sık olarak 11 olg...

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Human papillomavirus infection in the etiology of laryngeal carcinoma

Abstract: An adequately powered, multicenter case-control study is required to elucidate the full extent of this association and to examine the relation between the virus and other risk factors.

Cited by 40 publications

References 29 publications

Human papillomavirus in early laryngeal carcinoma

Human papillomavirus in early laryngeal carcinoma

Expression of matrix metalloproteinases (MMP-2 and MMP-9) in recurrent respiratory papillomas and laryngeal carcinoma: clinical and morphological parallels

Human Papilloma Virus Prevalence in Hyperplastic Tonsils and Adenoids in Children and Young Adults

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