Human papillomavirus infection in Barrett's oesophagus in the UK: An infrequent event

Rai, Nima; Jenkins, Gareth; McAdam, Elizabeth; Hibbitts, Samantha Jayne; Fiander, Alison; Powell, Ned

doi:10.1016/j.jcv.2008.07.004

Cited by 30 publications

(22 citation statements)

References 27 publications

(22 reference statements)

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“…Of note, the majority of HPV-positive cases were of types 6 and 11 which have low oncogenic potential. A study from UK 19 in contrast showed low frequency of HPV in Barrett's esophagus (1 out of 73 BE samples) which is consistent with earlier reports of absence of HPV infection in esophageal carcinomas. This study used a PCR based assay for HPV detection.…”

Section: Discussionsupporting

confidence: 89%

“…In comparison, the role of HPV in BE and esophageal carcinomas has been examined in only two studies to date. 18,19 A Mexican study 18 reported HPV in majority of their Barrett's esophagus cases (96%) and esophageal carcinomas (88%). The authors concluded that HPV was a clear risk factor in their population, although an etiological role could not be specifically defined.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Human papillomavirus is detectable in Barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance

Iyer

Rajendran

Adamson

et al. 2011

Journal of Clinical Virology

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Human papillomavirus is detectable in Barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance

Iyer

Rajendran

Adamson

et al. 2011

Journal of Clinical Virology

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“…Another study from the United Kingdom found that, among 73 patients with Barrett's esophagus with fresh-frozen samples, HPV DNA was found in only 1 case. 12 In contrast, a study of 28 patients with Barrett's esophagus from Mexico found HPV in 96% of patients, using paraffin-embedded specimens. 13 The Current Study Within this context enters the current study by Rajendra et al, 14 which aims to evaluate a fairly narrow question related to the associations between HPV, p53, and the persistence of HPV and p53 overexpression among patients treated with radiofrequency ablation.…”

Section: The Context Of Prior Researchmentioning

confidence: 95%

Does Human Papillomavirus Cause Esophageal Adenocarcinoma?

Corley

Silverberg

2015

Clinical Gastroenterology and Hepatology

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“…In this study, it was stated (but exact numbers not reported) that the majority of HPV-positive cases were of types 6 and 11, HPV types for which oncogenicity has not been established 1. Nevertheless, Rai et al 21 reported that the HPV infection in Barrett’s oesophagus is not common in the UK, although the choice of primers for the detection of HPV DNA may have been suboptimal. It should be noted that the historical use of HPV serology should not be regarded as a suitable method for determining or refuting a causal association between oesophageal mucosal infection with oncogenic HPV strains and oesophageal carcinoma (eg, Lagergren et al 22 or Kamangar et al 23): the presence of HPV at some time elsewhere in the body does not show its presence in the oesophageal mucosa, and the absence of persistently detectable concentrations of HPV antibodies does not demonstrate the absence of persistent oesophageal mucosal HPV infection.…”

Section: Evidence For An Analogous Association Between Human Papillommentioning

confidence: 99%

Similar immunogenetics of Barrett’s oesophagus and cervical neoplasia: is HPV the common denominator?

Rajendra

Robertson²

2009

J Clin Pathol

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There are a number of similarities between cervical cancer and oesophageal adenocarcinoma. As cervical cancer is overwhelmingly associated with oncogenic human papillomavirus (HPV) infection, the possibility that HPV is also associated with the aetiology of oesophageal adenocarcinoma needs to be examined. This paper presents the evidence for such an association and a discussion of what further studies would be needed to confirm such an association. EVIDENCE FOR AN ANALOGOUS ASSOCIATION BETWEEN HUMAN PAPILLOMAVIRUS (HPV) AND CERVICAL CANCER AND OESOPHAGEAL ADENOCARCINOMAHPV has been identified as the major aetiological factor in cervical carcinogenesis, 1 being detected in 90-100% of cervical cancer specimens compared with 20% of controls. 2 In addition, the HPV viral genome has been identified in most of the precursor lesions of cervical intraepithelial neoplasia. 3 HPVs are epitheliotropic and were thought to preferentially infect squamous epithelia only. However, it is now known that much of the virus is present at the squamocolumnar junction. Moreover, a consistent, strong and robust association between infection by high-risk HPV types and risk of development of adenocarcinoma of the cervix has been demonstrated. 4 5The role of HPV-mediated tumorigenesis in cervical cancer raises the question of the possible pathogenic role of the virus in oesophageal squamous and adenocarcinoma, oropharyngeal cancers and other non-genital malignancies. The recent demonstration of an association between HPV infection and oropharyngeal cancers, and the demonstration that this association may be related to direct or indirect orogenital transmission, reveals the exposure of the upper gastrointestinal tract to HPV infection. 6 There is some evidence for a plausible role for HPV in the pathogenesis of squamous cell carcinoma of the oesophagus. 7 High-risk-type HPV infections (predominantly HPV16 and HPV18) are detected in about 15% and 23% of patients with oesophageal squamous carcinoma using PCR and in situ hybridisation techniques, respectively. 7 HPV detection rates in oesophageal cancer are highly variable in different geographical areas of the world and are significantly higher in high-risk areas than in low-risk regions. 7 Oesophageal squamous papillomas are believed to arise from a multistep process involving HPV and chronic reflux. 8

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Human papillomavirus infection in Barrett's oesophagus in the UK: An infrequent event

Cited by 30 publications

References 27 publications

Human papillomavirus is detectable in Barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance

Human papillomavirus is detectable in Barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance

Does Human Papillomavirus Cause Esophageal Adenocarcinoma?

Similar immunogenetics of Barrett’s oesophagus and cervical neoplasia: is HPV the common denominator?

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