Human papillomavirus is detectable in Barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance

Iyer, Anita; Rajendran, Vanitha; Adamson, Christine S.-C.; Peng, Zhihua; Cooper, Kumarasen; Evans, Mark

doi:10.1016/j.jcv.2010.11.015

Cited by 40 publications

(28 citation statements)

References 21 publications

(13 reference statements)

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“…In contrast, the major histological type of esophageal cancer in western countries is adenocarcinoma, in which the majority of cases develop in Barrett's esophagus and commonly remain in a precancerous state. HPV has been reportedly identified in 31% of esophageal adenocarcinoma cases in the North American population [Iyer et al, 2010]. The higher HPV infection rate of esophageal cancer in North America compared to the present results could be attributable to the difference in the histological type rather than the regional difference.…”

contrasting

confidence: 58%

Human papillomavirus infection in lung and esophageal cancers: Analysis of 485 Asian cases

Goto

Ota

et al. 2011

Journal of Medical Virology

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The role of human papillomavirus (HPV) in the development of lung and esophageal cancer remains inconclusive, which is in contrast to the established role HPV plays in the development of uterine cervical cancer. One of the reasons for this is the difference among reported HPV infection rates in these cancers. An analysis of 485 lung and esophageal cancers (176 lung squamous cell carcinoma, 128 lung adenocarcinoma, 181 esophageal carcinoma) in eight institutions in Asia (Tokyo, Kochi, Kagoshima, and Okinawa, Japan; Seoul and Daegu, Korea; Changhua, Republic of China (Taiwan); Singapore, Singapore) was carried out in order to clarify infection rates with HPV. Samples were examined in one laboratory of the Department of Pathology, the University of Tokyo, Japan in order to avoid inter-laboratory variation using a combination of polymerase chain reaction and in situ hybridization (ISH). HPV was found in 6.3%, 7%, and 9.4% of patients with lung squamous cell carcinoma, lung adenocarcinoma, and esophageal cancer, respectively. Among the geographic areas surveyed, Kagoshima exhibited a significantly higher prevalence of HPV infection in cases of esophageal carcinoma (24.1%). There was no geographical difference in the infection rates of HPV in lung carcinomas. Subtype-specific ISH was also performed, which identified the high-risk HPV types 16/18 in the majority (75.7%) of the patients with lung and esophageal cancer positive for HPV.

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confidence: 58%

Human papillomavirus infection in lung and esophageal cancers: Analysis of 485 Asian cases

Goto

Ota

et al. 2011

Journal of Medical Virology

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“…A study by El-Serag et al, 10 using polymerase chain reaction on DNA extracted from freshfrozen biopsy specimens, did not detect HPV among any of 39 patients with nondysplastic Barrett's esophagus, leading the investigators to conclude that it was unlikely to be a causative agent. A study by Iyer et al 11 found HPV DNA in formalin-fixed samples in 27.4% of 84 patients with Barrett's esophagus, but also found it among 24% of 29 control patients who had gastroesophageal junction biopsy specimens without Barrett's esophagus, leading them to conclude that there was no association between HPV and Barrett's esophagus. Another study from the United Kingdom found that, among 73 patients with Barrett's esophagus with fresh-frozen samples, HPV DNA was found in only 1 case.…”

Section: The Context Of Prior Researchmentioning

confidence: 99%

Does Human Papillomavirus Cause Esophageal Adenocarcinoma?

Corley

Silverberg

2015

Clinical Gastroenterology and Hepatology

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“…Although HPV is shown to be present in various esophageal lesions and tumors, the etiologic significance of the same is doubtful. HPV DNA has been detected in 10–25% of cases with adenocarcinoma; however, it could not be detected in any of our adenocarcinoma cases [34,35]. The reasons for the divergent results may reflect the diversity of these lesions in different geographic regions.…”

Section: Discussionmentioning

confidence: 82%

Prevalence of Human Papilloma Virus in Esophageal Carcinomas: A Polymerase Chain Reaction-Based Study

Gupta¹,

Barwad²,

Rajwanshi³

et al. 2012

Acta Cytologica

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Objectives: Human papilloma virus (HPV) has been repeatedly found in esophageal carcinoma tissues. However, detection rates of HPV DNA in these tumors have varied markedly. Differences in detection methods, sample types and geographic regions of the sample origin have been suggested as potential causes of this discrepancy. This study was undertaken to analyze the prevalence of HPV in esophageal carcinoma. Study Design: HPV L1 DNA was evaluated in a total of 49 esophageal carcinoma samples, including 44 cases of squamous cell carcinoma (SCC) and 5 cases of adenocarcinoma. Seventeen control samples of esophageal brushings were also analyzed. The HPV L1 fragment was detected using MY09/MY11 primers. Results: In test samples, 17/49 (34.7%) were positive for HPV L1 and, in comparison, none of the control samples were positive. HPV DNA was identified in 17/37 (46%) cases of non-keratinizing SCC and was not identified in any case of esophageal keratinizing SCC and adenocarcinoma. Conclusion: This study defines a significant association of HPV with esophageal non-keratinizing SCC. Our findings raise the possibility that HPV is involved in esophageal carcinogenesis, especially the non-keratinizing type of SCC. Further investigation with a larger sample size over broader geographic areas may be warranted.

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Human papillomavirus is detectable in Barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance

Cited by 40 publications

References 21 publications

Human papillomavirus infection in lung and esophageal cancers: Analysis of 485 Asian cases

Human papillomavirus infection in lung and esophageal cancers: Analysis of 485 Asian cases

Does Human Papillomavirus Cause Esophageal Adenocarcinoma?

Prevalence of Human Papilloma Virus in Esophageal Carcinomas: A Polymerase Chain Reaction-Based Study

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