Human Papillomavirus infection and cervical lesions in HIV infected women on antiretroviral treatment in Thailand

Delory, Tristan; Ngo‐Giang‐Huong, Nicole; Rangdaeng, Samreung; Chotivanich, Nantasak; Limtrakul, Aram; Putiyanun, Chaiwat; Suriyachai, Pornnapa; Matanasarawut, Wanmanee; Jarupanich, Tapnarong; Liampongsabuddhi, Prateung; Heard, Isabelle; Jourdain, Gonzague; Lallemant, Marc; Cœur, Sophie Le; Zarca, Kevin; Brunet‐Possenti, F.; Blake, Alexandre; Althaus, Thomas; Gallot, C.; Desbiolles, Alice; Fayard, Florence; Dib, Fadia; Pluart, Diane Le; Prouté, Myrtille; Tiv, Métrey; Banchongkit, Sukit; Bowonwatanuwong, Chureeratana; Buranabanjasatean, Sudanee; Chutanunta, Apichat; Naree, Eiamsirikit; Halue, Guttiga; Kantipong, Pacharee; Klinbuayaem, Virat; Kongpanichkul, Rucha; Leenasirimakul, Prattana; Lertkoonalak, Rittha; Luekamlung, Nuananong; Panna, Sunida; Paramee, Rattakarn; Pathipvanich, Panita; Prommas, Sinart; Puarattana-Aroonkorn, Nusra; Sang-A-Gad, Pensiriwan; Tansuphasawasdikul, Somboon; Tantinam, Kosit; Theansavettrakul, Sookchai; Thongpaen, Suchart; Wittayapraparat, Pakorn; Yuthavisuthi, Prapap; Yutthakasemsunt, Naruepon

doi:10.1016/j.jinf.2017.02.007

Cited by 15 publications

(25 citation statements)

References 34 publications

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“…It has been suggested that the increase in the perimenopause period may be due to higher rates of HPV persistence and recurrence at older ages rather than new HPV acquisition, [ 59 ] and that viral characteristics such as HPV type and variants, [ 60 ] weakened immune system, changes in sexual behaviour during middle age (both for men and women [ 61 ]), or previous individual screening practices, may play a role [ 56 ]. The association between younger age and higher prevalence of HR-HPV is probably due to the presence of transient infections in this group of women; however, this association is generally observed in non-HIV infected women but is not consistent in women living with HIV/AIDS [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

“…In most studies of HIV and HPV, the magnitude of increased HPV prevalence was proportional to the severity of immunosuppression [ 10 , 18 , 38 , 63 – 65 ]. While many HPV infections are transient, women living with HIV are more likely to have persistent HPV infections, [ 66 ] and in other studies the frequency of persistence varied inversely with CD4 cell count [ 62 , 65 ]. These results suggest that HIV induced immunosuppression might cytological findings was 21.9%, higher than the global estimate of 16.1% reported a meta-analysis for women in the general population from Latin America [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

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High risk human papillomavirus prevalence and genotype distribution among women infected with HIV in Manaus, Amazonas

Teixeira

Sabidó

Leturiondo

et al. 2018

Virol J

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BackgroundHuman immunodeficiency virus (HIV)-positive women have a high prevalence of human papillomavirus (HPV), and are infected with a broader range of HPV types than HIV-negative women. We aimed to determine the prevalence of cervical cytologic abnormalities, high-risk (HR)-HPV prevalence, type distribution according to the severity of cervical lesions and CD4 cell count and identify factors associated with HR-HPV infection among women living with HIV in Manaus, Amazonas.MethodsWe enrolled 325 women living with HIV that attended an infectious diseases referral hospital. Each woman underwent a gynecological exam, cervical cytology, HR-HPV detection by Polymerase chain Reaction (PCR) using the BD Onclarity™ HPV Assay, colposcopy and biopsy, when necessary. We assessed the associations between potential risk factors and HR-HPV infection.ResultsOverall, 299 (92.0%) women had a PCR result. The prevalence of HR-HPV- infection was 31.1%. The most prevalent HR-HPV types were: 56/59/66 (32.2%), 35/39/68 (28.0%), 52 (21.5%), 16 (19.4%), and 45 (12.9%). Among the women with HR-HPV infection (n = 93), 43.0% had multiple infections. Women with HPV infection showed higher prevalence of cervical abnormalities than that HPV-negative (LSIL: 22.6% vs. 1.5%; HSIL: 10.8% vs. 0.0%). The prevalence of HR-HPV among women with cytological abnormalities was 87.5% for LSIL and 100.0% for HSIL. Women with CD4 < 200 cell/mm3 showed the highest HR-HPV prevalence (59.3%) although this trend was not statistically significant (p-value = 0.62). The mean CD4 cell count decreased with increasing severity of cervical lesions (p-value = 0.001). The multivariable analysis showed that increasing age was associated with a decreased risk of HR-HPV infection with an adjusted prevalence odds ratio of 0.9 (95.0% CI: 0.9–1.0, p-value: 0.03) for each additional year. The only factor statistically significant associated with HR-HPV infection was CD4 cell count.ConclusionsHR-HPV and abnormal cytology prevalence are high among women in the Amazonas. The low CD4 cell count was an important determinant of HPV infection and abnormal cytological findings. HPV quadrivalent vaccination used in Brazil might not offer protection for an important fraction of HPV-related disease burden in women living with HIV. This is partly explained by the high presence of non targeted vaccine HR-HPVs, such as the HPV genotype groups 56/59/66, 35/39/68 and individually HPV-52 and HPV-45, some of which contribute to high-grade lesion.Electronic supplementary materialThe online version of this article (10.1186/s12985-018-0942-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High risk human papillomavirus prevalence and genotype distribution among women infected with HIV in Manaus, Amazonas

Teixeira

Sabidó

Leturiondo

et al. 2018

Virol J

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show abstract

“…HPV vaccine initiatives targeting PLWH require knowledge on concordant HPV genotype distribution at all anatomical sites to estimate multisite vaccine efficacy. While several studies on women living with HIV (WLWH) report cervical, oral, or anal HPV genotype distribution [19][20][21][22][23][24][25], only few, small studies have addressed concurrent cervical, oral, and anal HPV prevalence [26][27][28].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Prevalence of cervical, oral, and anal human papillomavirus infection in women living with HIV in Denmark – The SHADE cohort study

Thorsteinsson

Storgaard

Katzenstein

et al. 2018

Journal of Clinical Virology

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“…En la actualidad con los tratamientos retrovirales y buen control de la carga tumoral su asociación es baja y su influencia en el pronóstico menor, asi concluye su trabajo Delory con el studio de 829 pacientes infectadas con HIV y en tratamiento antiretroviral (50) El hábito tabáquico es conocido como en mayor factor extrínseco asociado al desarrollado de diversos tumors malignos, entre ellos el CC (51,52). También la exposición laboral con el polvo del tabaco se ha asociado con aumento de riesgo de padecer CC (52).…”

Section: Estadio Figo Supervivencia a 5 Años Control Local A 5 Añosunclassified

“…La coexistencia de CC e infección por VIH ha tenido en el pasado mal pronóstico por el estado inmunitario de las pacientes. En la actualidad con los tratamientos retrovirales y buen control de la carga tumoral su asociación es baja y su influencia en el pronóstico menor (173) . No existen protocolos especiales para estas pacientes y su tratamiento es igual a las no infectadas (174) En nuestra serie son muy pocas pacientes las que presentan asociación de ambas patología (solo 3 casos) y su evolución ha sido muy parecida a las pacientes no infectadas, así la supervivencia a 5 años fue de 66% para las pacientes infectadas, vs 58 % para las que no padecían la enfermedad, sin significación estadística entre ambas (p=0,366).Las pacientes tratadas en nuestra serie estaban bien controladas con su tratamiento antiretroviral, sin carga tumoral detectable y recibieron el tratamiento a dosis plenas sin diferencias entre las pacientes infectadas y las que no, al igual que en los resultados como hemos visto.…”

Section: Estadio Figo Supervivencia a 5 Añosunclassified

Combinación de quimioterapia y radioterapia en el tratamiento del carcinoma de cérvix: análisis de resultados en nuestro medio y estudio de la influencia de la duración del mismo en la supervivencia

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Human Papillomavirus infection and cervical lesions in HIV infected women on antiretroviral treatment in Thailand

Cited by 15 publications

References 34 publications

High risk human papillomavirus prevalence and genotype distribution among women infected with HIV in Manaus, Amazonas

High risk human papillomavirus prevalence and genotype distribution among women infected with HIV in Manaus, Amazonas

Prevalence of cervical, oral, and anal human papillomavirus infection in women living with HIV in Denmark – The SHADE cohort study

Combinación de quimioterapia y radioterapia en el tratamiento del carcinoma de cérvix: análisis de resultados en nuestro medio y estudio de la influencia de la duración del mismo en la supervivencia

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