Prevalence of cervical, oral, and anal human papillomavirus infection in women living with HIV in Denmark – The SHADE cohort study

Thorsteinsson, Kristina; Storgaard, Merete; Katzenstein, Terese L.; Ladelund, Steen; Rönsholt, Frederikke Falkencrone; Johansen, Işik Somuncu; Pedersen, Gert Frølund; Gaardsting, Anne; Nielsen, Lars N.; Bonde, Jesper; Lebech, Anne‐Mette

doi:10.1016/j.jcv.2018.05.010

Cited by 17 publications

(25 citation statements)

References 47 publications

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“…It has been suggested that the prevalence of HPV in the oral cavity in HIV+ women is considerably low [19]. In our study, the prevalence of infection with any of the 12 HPV types considered was 92.5%, which contrasts with the range of 5.6%-34% in women living with HIV [12,20]. Other studies in HIV+ individuals have reported an HPV prevalence in the oral cavity Table 3.…”

Section: Plos Onecontrasting

confidence: 67%

High prevalence of human papillomavirus and European variants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women

et al. 2020

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Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide, with a high prevalence and high transmissibility. High-risk HPV (hrHPV) infection is the primary cause of cervical cancer. The HPV variants present in the uterine cervix and oral cavity of HIV+ women have not been described. Objective Identify the prevalence of HPV infections in the uterine cervix and oral cavity and HPV16 variants in HIV+ women. Methods A total of 174 HIV+ women attended an HIV+ specialized clinic in Mexico City. Cells were obtained from the oral cavity and cervix to extract DNA. Polymerase chain reaction (PCR) was used to amplify the HPV sequence with generic primers. We detected specific HPV types using the INNO-LiPA HPV Genotyping Extra II Kit (INNOGENETICS). The

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Section: Plos Onecontrasting

confidence: 67%

High prevalence of human papillomavirus and European variants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women

et al. 2020

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“…in HIV+ women and 2%-31.4% in HIV-women) [20,24,33]. These results suggest that the prevalence of cervical and oropharyngeal HPV infection may vary widely according to the anatomical sites, study population, geographical region, and detection methods applied, but oropharyngeal HPV infection seems to be less common irrespective of the population group studied.…”

Section: Table 5 Discussionmentioning

confidence: 79%

“…The prevalence of cervical HPV infection was 44.3% in HIV+ women and 37.4% in HIV-women. Studies across different populations showed varying prevalenceof HPV infection, that is, 45-97.1% in HIV+ women and 44.9-86.5% in HIV-women in the cervical site [20,24,25,33]. However, the prevalence of oropharyngeal HPV infection in HIV+ women and HIV-control were 14.8% and 9.4%, respectively.…”

Section: Table 5 Discussionmentioning

confidence: 99%

“…HPV types that were most prevalent in cervical samples were hrHPV18 and hrHPV58 in both HIV+ and HIV-women; however, hrHPV45 and hrHPV16 were frequently detected in HIV+ women and HIV-women, respectively. Prevalence studies around the world have shown that the hrHPV types 16,18,31,33,35,52, and 58 are the most commonly detected hrHPVs in CC, with hrHPV16 being the most common in all populations, with the exception of HIV+ populations [1]. Data have consistently shown that HIV+ women are frequently more infected with types of hrHPV other than hrHPV16 and hrHPV18, such as hrHPV52 and hrHPV58 [40].…”

Section: Table 5 Discussionmentioning

confidence: 99%

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Cervical and oropharyngeal human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil

Suehiro

Damke

et al. 2020

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Background: Despite the demonstrated role of human Papillomavirus (HPV) in the etiology of cervical cancer and the strong evidence suggesting the importance of HPV in the development of oropharyngeal cancer, several aspects concerning the interrelationship between HPV infections in both body sites remain unknown, specifically in human immunodeficiency virus (HIV)-positive (HIV+) female patients. We aimed to assess the prevalence, distribution, and concordance of cervical and oropharyngeal HPV in HIV+ women and matched HIV-negative (HIV-) controls in Brazil. Material and methods: Cervical and endocervical samples for cytological screening and HPV detection and oropharyngeal samples were collected from 115 HIV+ women using highly active antiretroviral therapy (HAART) and 139 HIV-matched controls (HIV-) in Maringá City, Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding HIV infection were obtained from the patients’ medical records. Detection and typing of HPV were performed using the Kit Multiplex XGEN Multi HPV Chip HS12. Results: HIV infection was well controlled in this cohort, but women who exhibited 1–100.000 viral copies/mL were significantly associated with HPV-positive status (P = 0.03). HIV+ women had significantly more abnormal cytological findings (P = 0.04) than HIV- women. Of the 115 HIV+ women, 48.7% were positive for cervical and/or oropharyngeal HPV DNA; of the 139 HIV- women, 41% were positive for cervical and/or oropharyngeal HPV (P = 0.25). Both HIV+ and HIV- women had a statistically higher prevalence of cervical HPV infection than oropharyngeal infection. The concurrent HPV infection in two anatomical sites was similar in HIV+ and HIV- women, however HPV type concordance was not observed. HPV type distribution was different between the anatomical sites in both groups, and HIV+ women presented types less common, mainly in oropharyngeal mucosa. Conclusion: Our data support the importance of HPV infection in HIV+ women, even when the HIV infection is well controlled. Prospective studies are required to better understand the natural history of HPV infection in both anatomical sites, specifically in HIV+ women.

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“…Full-mouth oral/oropharyngeal scraping, including the cheeks, tongue, palate, tonsils, and oropharynx, was performed using a sterile brush with soft bristles; samples were stored in ThinPrep® Pap Test solution. Moreover, a gargle sample was obtained by having the participant gargle with 10 mL of 0.9% sterile saline for a total of 30 seconds (10s, rinse; 5s, gargle; 10s rinse; 5s, gargle), collected in a sterile cup and stored at -4°C [20,32]. All oral/oropharyngeal samples will be referred as "oral samples.…”

Section: Sample Collectionmentioning

confidence: 99%

Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil

Suehiro

Damke

et al. 2020

Preprint

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Background: Despite the demonstrated role of human Papillomavirus (HPV) in the etiology of cervical cancer and the strong evidence suggesting the importance of HPV in the development of oropharyngeal cancer, several aspects of the interrelationship between HPV infection in both body sites remain unknown, specifically in female human immunodeficiency virus (HIV)-positive (HIV+) patients. We aimed to assess the prevalence, distribution, and concordance of cervical and oral HPV in HIV+ women and matched HIV-negative (HIV-) controls in Brazil.Material and methods: Cervical and endocervical samples for cytological screening and HPV detection and oral samples were collected from 115 HIV+ women using highly active antiretroviral therapy (HAART) and 139 HIV-matched controls (HIV-) in Maringá City, Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding HIV infection were obtained from the patients’ medical records. HPV detection and typing were performed using the Kit Multiplex XGEN Multi HPV Chip HS12.Results: HIV infection was well controlled in this cohort, but women who exhibited detectable HIV loads were significantly associated with HPV-positive status overall (P = 0.03) and in cervical mucosa (P = 0.01). HIV+ women had significantly more abnormal cytological findings (P = 0.04) than HIV- women. Of the 115 HIV+ women, 48.7% were positive for cervical and/or oral HPV DNA; of the 139 HIV- women, 41% were positive for cervical and/or oral HPV (P = 0.25). Both HIV+ and HIV- women had a statistically higher prevalence of cervical HPV infection than oral infection. The concurrent HPV infection in two anatomical sites was similar in HIV+ and HIV- women; however, HPV type concordance was not observed. HPV type distribution was different between the anatomical sites in both groups, and HIV+ women presented less common types, mainly in oral mucosa.Conclusion: Our data support the importance of testing HPV infection in HIV+ women, even when the HIV infection is well controlled. Prospective studies are required to better understand the natural history of HPV infection in both anatomical sites, specifically in HIV+ women.

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Prevalence of cervical, oral, and anal human papillomavirus infection in women living with HIV in Denmark – The SHADE cohort study

Abstract: Cervical and anal HPV infection were highly prevalent in WLWH. Non-16/18 hrHPV genotypes were predominant at all anatomical sites. Almost half of all hrHPV infections at the three anatomical sites could have been prevented by childhood/adolescent vaccination with the 9-valent HPV vaccine.

Cited by 17 publications

References 47 publications

High prevalence of human papillomavirus and European variants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women

High prevalence of human papillomavirus and European variants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women

Cervical and oropharyngeal human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil

Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil

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