Human papillomavirus in normal conjunctival tissue and in conjunctival papilloma: types and frequencies in a large series

Sjö, Nicolai Christian; Buchwald, Christian von; Cassonnet, Patricia; Norrild, Bodil; Prause, Jan Ulrik; Vinding, Troels; Heegaard, Steffen

doi:10.1136/bjo.2006.108811

Cited by 76 publications

(48 citation statements)

References 15 publications

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“…1,2,4 In people, papillomas of the conjunctiva are often, but not invariably, associated with human papillomavirus. 5 At the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW), we recognize 2 categories of primary benign papillomas of the conjunctival surface: those with characteristic features of papillomavirus infection and those with features resembling those seen in cutaneous squamous papillomas. Here, we describe the features of squamous papillomas of the conjunctival surface in dogs that do not present features associated with papillomavirus infection and differentiate them from their viral counterpart.…”

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confidence: 99%

Squamous Papillomas of the Conjunctiva in Dogs

et al. 2014

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Papillomas of the conjunctival surface in people can be of viral or nonviral origin and are found in high association with human papillomavirus. Canine conjunctival papillomas are seldom described, and published accounts have mostly been associated with canine oral papillomavirus infection. Here, we describe conjunctival squamous papillomas that do not express papillomavirus proteins and compare them with papillomavirus-associated conjunctival papillomas. Conjunctival squamous papillomas presented a distinct histopathologic profile and lacked the cytopathic effects seen in viral papillomas. They appeared as exophytic, papilliferous, pedunculated lesions with delicate fronds and angular terminal margins. Squamous papillomas presented with a delicate fibrovascular core and were associated both clinically and grossly with a feeder vessel. Pigmentation was variable within the epithelium and stroma of these lesions, and inflammatory infiltrates were characteristically minimal. Conjunctival squamous papillomas resembled squamous papillomas of the skin; however, they lacked significant hyperkeratosis. Compared with conjunctival viral papillomas, these masses occurred in older dogs and were smaller and solitary. Furthermore, polymerase chain reaction and immunohistochemistry failed to demonstrate papillomavirus genetic material and antigens in conjunctival squamous papillomas. Both viral and nonviral conjunctival papillomas were considered benign.

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confidence: 99%

Squamous Papillomas of the Conjunctiva in Dogs

et al. 2014

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“…Pedunculated papillomas similar to the one reported here are strongly associated with infectious etiology. In the United States, prevalence of conjunctival papilloma ranges from 4 to 12%, and formation is strongly associated with HPV types 6 and 11 [3]. Although HPV 6 and 11 types are generally low risk, it can sometimes present with dysplasia.…”

Section: Discussionmentioning

confidence: 99%

Long standing exophytic conjunctival papilloma infected with human papillomavirus

Annadanam¹,

Vizcaíno²,

Eberhart³

et al. 2017

J Eye Ophthalmol

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Background: Most conjunctival papillomas are benign in nature. However, any long standing conjunctival mass should not evade the surveillance of carcinogenicity. Presented here is a case of a long standing conjunctival papilloma (HPV) that showed the presence of low risk human papillomavirus based on histological testing. Methods: This is a retrospective review of a case of a patient with a longstanding conjunctival mass that was surgically excised. Baseline demographics, ocular history, and pathology reports are presented. Results: A 48-year-old man presented for urgent care evaluation of a growth on his left lower eyelid that was itchy and bled intermittently with eye rub. Ocular examination of the lower eyelid revealed a large pink pedunculated mass on the palpebral conjunctiva. The patient underwent excision of the mass with conjunctivoplasty and ocular surface reconstruction. Histopathology of the tissue revealed the mass to be a conjunctival papilloma with positive staining for low-risk HPV types 6 and 11. Conclusion: Although the chronic nature of the lesion reduces malignant potential, staining for low risk HPV 6 and 11 was present. Any longstanding papilloma warrants histopathology workup to help with appropriate medical or surgical management.

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“…Overall, the data presented in the current report (Figures 1a and b) contrasts with the 80% prevalence rate of HPV in conjunctival papillomas in over 200 cases, most of which were classified as 'low-risk' HPV types -6 and -11. 64,65 Differences in HPV prevalence rates for OSSN may be explained by the same design faults identified in studies that assessed HPV in pterygia. The most severe limitation from studies that analyzed both diseases was that HIV status was not disclosed.…”

Section: Pterygia: Characteristics and Pathogenic Mechanismsmentioning

confidence: 99%

Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia

Girolamo

2011

Eye

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There are more microorganisms that colonize the human body than resident cells; some are commensal whereas others are pathogenic. Pathogenic microorganisms are sensed by the innate or adaptive immune system, an immune response is initiated, and the infection is often cleared. Some microorganisms have developed strategies to evade immune defenses, ensuring their long-term survival with potentially devastating consequences for the host. Approximately 18% of all cancers can be attributed to infective agents; the most common being Helicobacter pylori, Human papilloma virus (HPV) and Hepatitis B and C virus in causing stomach, cervical and liver carcinoma, respectively. This review focuses on whether HPV infection is necessary for initiating pterygia, a common benign condition and ocular-surface squamous neoplasia (OSSN), a rare disease with metastatic potential. The search engine PubMed was used to identify articles from the literature related to HPV and pterygium or conjunctival neoplasia. From 34 investigations that studied HPV in pterygia and OSSN, a prevalence rate of 18.6% (136/731) and 33.8% (144/426), respectively, was recorded. The variation in HPV prevalence (0-100%) for both disease groups may have arisen from study-design faults and the techniques used to identify the virus. Overall, the data suggest that HPV is not necessary for initiating either condition but may be a co-factor in susceptible hosts. Currently, over 60 million people worldwide have been immunized with HPV vaccines, but any effect on pterygium and OSSN development may not be known for some time as these lesions can evolve over decades or occur in older individuals.

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Human papillomavirus in normal conjunctival tissue and in conjunctival papilloma: types and frequencies in a large series

Cited by 76 publications

References 15 publications

Squamous Papillomas of the Conjunctiva in Dogs

Squamous Papillomas of the Conjunctiva in Dogs

Long standing exophytic conjunctival papilloma infected with human papillomavirus

Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia

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