Human papillomavirus in conjunctival papilloma

Abstract

Aim-To examine conjunctival papillomas for the presence of human papillomavirus (HPV) and koilocytosis. Methods-Archival paraYn embedded tissue from 55 conjunctival papillomas was analysed for the presence of HPV by polymerase chain reaction and subsequent filter hybridisation. Histological sections of the 55 papillomas were evaluated for the presence of koilocytosis. Results-HPV was present in 48 of 52 (92%) globin positive papillomas. HPV type 6/11 were found in 40 of 47 investigated papillomas and a double infection with HPV 6/11 and 16 was identified in a single papilloma. In six papillomas the HPV type could not be identified. Koilocytosis was present in 22 of 55 papillomas (40%). Conclusion-There is a strong association between HPV and conjunctival papillomas. HPV type 6/11 is the most common HPV type in conjunctival papilloma. The sensitivity of koilocytosis as an indicator of HPV in conjunctival papilloma is low. (Br J Ophthalmol 2001;85:785-787)

Inverted mucoepidermoid papilloma of conjunctiva in a child

“…5 The squamous cell papilloma of the conjunctiva is known to be associated with human papillomavirus (HPV types 6, 11, 16 and 18) infection of the conjunctiva. 6 Although Chang and colleauges 8 found an association between human papillomavirus and inverted papilloma of the conjunctiva in their case, the etiology of these conjunctival tumors could not be determined in the remaining reported cases.…”

“…4 In a few isolated cases in adults the lesions were found at the caruncle, tarsus, and epibulbar surface. [4][5][6][7] Inverted mucoepidermoid papilloma at the corneoscleral limbus and in children is even rarer.…”

“…They exhibit a strong tendency for local recurrence and can undergo malignant transformation, although this is uncommon. [2][3][4][5][6][7][8] In contrast to the exophytic growth pattern of squamous cell carcinomas, inverted papillomas are characterized by folds and ribbons of papillomatous epithelium with endophytic downward growth into the underlying stroma.…”

Oral Cimetidine Adjuvant Therapy for Recalcitrant, Diffuse Conjunctival Papillomatosis

“…12,13 A conjunctival sample from our patient was infected with HPV-6, the most common papillomavirus found in the female genital tract. The presence of genital tract HPV-6 in conjunctival lesions might be caused by vertical transmission during passage through the birth canal.…”

The eye in sexually transmitted infections: a review of the ocular complications of venereal diseases

“…Both children and adults can acquire these lesions; however, they are more commonly found in sexually active patients in their 20s and 30s. Acquisition of such papillomas can occur as an STD, autoinoculation, or as a result of maternal transmission to the newborn [40][41][42].…”