Inverted mucoepidermoid papilloma of conjunctiva in a child

Bhushan, Gauri; Raina, Usha K; Gupta, Anika; Bhambhwani, Vishaal; Khurana, Nita; Ghosh, Basudeb

doi:10.1016/j.jaapos.2014.12.006

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…7 To date, only 15 inverted (endophytic) Schneiderian papillomas of the conjunctiva have been described. [8][9][10][11][12][13][14][15][16] Two of these cases displayed focal malignant transformation. 10,15 To the authors' knowledge, no exophytic Schneiderian-type conjunctival papillomas have been reported.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Exophytic Schneiderian-type Papillomas: A Rare Occurrence

Charles

Stagner

Raju

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Conjunctival papillomas are common tumors that exhibit an exophytic growth pattern, comprised of multiple filiform fronds of squamous epithelium that contain fibrovascular cores. The inverted (endophytic) variety of papilloma, often termed “Schneiderian,” rarely occurs on the conjunctiva, with only 15 cases reported to date. Endophytic and exophytic papillomas are well described arising in the sinonasal Schneiderian epithelium where a low rate of malignant transformation may occur in the endophytic type; malignant transformation in exophytic sinonasal papillomas is exceedingly rare. The authors describe 2 cases of exophytic conjunctival papillomas with the morphology of a sinonasal or Schneiderian-type papilloma. Both were pink, sessile acquired growths in women in the sixth decade of life involving the inferior conjunctival fornix or nasal limbus. Nonkeratinizing squamous epithelium along with numerous goblet cells, intraepithelial mucinous cysts, and microabscesses were present. Immunohistochemistry showed reactivity for cytokeratin 7 and wild-type staining for p16 and p53, paralleling the findings in common conjunctival papillomas; both were also driven by low-risk human papillomavirus.

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Section: Discussionmentioning

confidence: 99%

Conjunctival Exophytic Schneiderian-type Papillomas: A Rare Occurrence

Charles

Stagner

Raju

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…The previously reported cases of inverted conjunctival papillomas have shown a broad variety regarding the clinical appearance, in accordance to our results. Inverted papillomas are described as pigmented, partly pigmented or completely unpigmented lesions, enlarging over a few months to several years and affecting females and males equally 3–10. Yet it is worth noticing that pigmentation of the papilloma by clinical evaluation has been described in 5 out of 15 lesions, in contrast to exophytic papilloma where pigmentation is rarely described.…”

Section: Discussionmentioning

confidence: 99%

“…Inverted conjunctival papilloma is exceedingly rare. To date, only 11 cases of inverted conjunctival papilloma have been reported 3–10. Due to its rareness, the aetiology and underlying biology are uncertain.…”

Section: Introductionmentioning

confidence: 99%

Inverted papilloma of the conjunctiva

et al. 2019

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ObjectiveThe purpose of the present study is to describe the clinical and histopathological features of conjunctival inverted papilloma, to analyse for the presence of human papillomavirus (HPV), and to determine if HPV infection is associated with this type of tumour and its inverted growth pattern.Methods and AnalysisCases of conjunctival inverted papillomas were retrieved from the archives of the Department of Pathology, Rigshospitalet, Denmark. Patient records and pathology reports were reviewed. Formalin-fixed and paraffin-embedded tissue was analysed for the presence of HPV by immunohistochemistry, in situ hybridisation (ISH), PCR and HPV typed by sequencing.ResultsA total of four cases were retrieved. The age at diagnosis ranged from 41 to 77 years, with an equal sex distribution. All lesions were localised to the bulbar conjunctiva and two of the cases were pigmented. Histopathological examination did not reveal areas of dysplasia. All lesions were p16-positive and p53-positive by immunohistochemistry. High-risk HPV 58 was demonstrated in one lesion by ISH and PCR.ConclusionHere we present four cases of conjunctival inverted papilloma, which is an exceedingly rare tumour with only 11 previously reported cases in the literature. Both clinically and histopathologically, the tumours show distinct features compared with exophytic conjunctival papillomas. Furthermore, this is the first description of high-risk HPV 58 in a conjunctival tumour. The biological behaviour of the tumour is uncertain due to its rareness. However, a complete removal of the lesion and a careful observation are recommended. The finding of HPV 58 underlines the necessity of this precaution.

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Inverted mucoepidermoid papilloma of conjunctiva in a child

Cited by 2 publications

References 9 publications

Conjunctival Exophytic Schneiderian-type Papillomas: A Rare Occurrence

Conjunctival Exophytic Schneiderian-type Papillomas: A Rare Occurrence

Inverted papilloma of the conjunctiva

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