Human papillomavirus (HPV) prevalence and associated risk factors in women from Curaçao

Hooi, Desiree J.; Lissenberg‐Witte, Birgit I.; Kenter, Gemma G.; Koning, Maurits N.C. de; Bravio, Igor Gomes; Ardts, Kim; Kleinmoedig, Suhaina; Benita, Edlyn; Pinedo, H.M.; Berkhof, Johannes; Quint, Wim; Meijer, Chris J.L.M.

doi:10.1371/journal.pone.0199624

Cited by 14 publications

(17 citation statements)

References 14 publications

(18 reference statements)

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“…The large sample sizes enable precise estimates of both increases and decreases in HPV type specific prevalence, which could be used as a baseline for comparison to future samplings of the population. The overall prevalence of HPV DNA in this representative sample of women was 18.71%, with the highest prevalence (33.11%) among women aged less than 21 years, corresponding with the data reported by Curacao (19.7%) [15]. Global HPV prevalence estimates are well-known to vary by the region, study design, target population and calendar time [16].…”

Section: Discussionsupporting

confidence: 78%

Prevalence and genotype distribution of HPV infection among 214,715 women from Southern China, 2012-2018: baseline surveys prior to mass HPV vaccination

Luo

Qiao-tu

et al. 2020

Preprint

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Background : The epidemiology on the human papillomavirus (HPV) among females in Southern China is not well-established. Baseline data on the prevalence of HPV infection in China prior to mass prophylactic HPV vaccination would be useful. Thus, this study aimed to determine the type-specific HPV prevalence and distribution among females from Southern China prior to mass HPV vaccination.Methods : A retrospective cross-sectional study employing 214,715 women attending ChenZhou NO.1 People’s Hospital for cervical screening during 2012-2018 was conducted prior to widespread HPV vaccination. HPV genotype was detected using nucleic acid molecular diversion hybridization tests. The overall prevalence, age-specific prevalence, type distribution，and annual trend was analyzed.Results : The overall HPV prevalence was 18.71% (95% confidence interval [CI], 18.55%-18.88%) among Southern China females. During 2012–2018, the prevalence of HPV infection showed a downward tendency, from 21.63% (95% CI, 21.07%-22.20%) in 2012 to 18.75% (95% CI, 18.35%-19.16%) in 2018. Age-specific HPV distribution displayed a peak at young women aged less than 21 years (33.11%, 95% CI, 31.13%-35.15%), 20.07% ( 95% CI, 19.70%-20.44% ) among women aged 21-30 years, 17.29% (95% CI, 17.01%-17.57%) among women aged 31-40 years, 17.23% (95% CI, 16.95%-17.51%) among women aged 41-50 years, 21.65% (95% CI, 21.11%-22.20%) among women aged 51-60 years, and 25.95% (95% CI, 24.86%-27.07%) among women aged over 60 years. Of the 21 subtypes identified, the most three prevalent high-risk HPV (HR-HPV) genotypes were HPV52 (5.12%; 95% CI, 21.11%-22.20%), -16 (2.96%; 95% CI, 2.89%-3.03%), and -58 (2.51%; 95% CI, 2.44%-2.58%); the predominant low-risk HPV (LR-HPV) genotypes were HPV81 (1.86%; 95%CI, 1.80%-1.92%) and -6 (0.69%; 95% CI, 0.66%-0.73%) respectively. Incidence of HR-HPV only, LR-HPV only and mixed LR- and HR-HPV were 15.17%, 2.07% and 1.47% respectively. Besides, single HPV infection accounted for 77.30% of all positive cases in this study.Conclusions: This study highlights 1) a high prevalence of HPV infection among females with a decreasing tendency towards 2012-2018, especially for young women under the age of 21 prior to mass HPV vaccination; 2) HPV52, -16 and -58 were the predominant HPV genotypes, suggesting potential use of HPV vaccine covering these HPV genotypes in Southern China.

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Section: Discussionsupporting

confidence: 78%

Prevalence and genotype distribution of HPV infection among 214,715 women from Southern China, 2012-2018: baseline surveys prior to mass HPV vaccination

Luo

Qiao-tu

et al. 2020

Preprint

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“…Moreover, HPV infections were significantly region‐specific . One study in Beijing showed that the overall HPV infection rate was 6.7%, and the infection rate of cervical HPV infections in women without cytological abnormalities was only 4.8% .…”

Section: Discussionmentioning

confidence: 99%

The distribution and prevalence of human papillomavirus in women in mainland China

Song

et al. 2019

Cancer

129

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We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status. A total of 198 eligible studies were included. The results of metaanalysis showed that the overall infection rate of high-risk HPVs in mainland Chinese women was 19.0% (95% confidence interval [CI], 17.1%-20.9%), and the top 5 subtypes with the highest infection rates were 16, 52, 58, 53, and 18. The overall infection rates of cervical intraepithelial neoplasia I (CINI), CINII+, and cervical cancer patients were 59.6% (95% CI, 52.7%-66.4%), 84.8% (95% CI, 81.2%-88.5%), and 89.9% (95% CI, 86.6%-93.1%), respectively. The high-risk HPV infections and common subtypes in women of various ages in various regions were different, and the high-risk HPVs and subtypes in cervical cancer patients in various regions were also different. In conclusion, we systematically analyzed the HPV infections in women who live on the Chinese mainland. The epidemiology of high-risk HPVs in mainland Chinese women is basically consistent with that for the rest of the world. The HPV vaccines currently licensed in China could cover the major prevalent high-risk HPV subtypes in China, providing a basis for the development of cervical cancer screening strategy and the vaccine implementation in China.

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“…A striking finding of this study was that less than one third of GPs interviewees stated that they often or always collect information on the sexual habits of 12–26 years’ girls and boys. It is worth mentioning that GPs should be aware of population groups at risk for unhealthy sex life habit since such behavior plays an important role in the process of high-risk HPV persistent infection for adolescents and young adults [ 20 , 21 , 22 ]. Therefore, it is important to know the adolescent’s sexual habits in order to prioritize preventive strategies and to develop educational campaigns that should be routinely conducted to prevent the spread of HPV.…”

Section: Discussionmentioning

confidence: 99%

HPV Vaccination Attitudes and Behaviors among General Practitioners in Italy

et al. 2021

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This cross-sectional electronic online or telephone survey assessed the attitudes and behaviors regarding human papillomavirus (HPV) vaccination and the effect of different factors among a nationally representative random sample of 349 general practitioners (GPs) in Italy. A semi-structured interview was performed between September 2018 and October 2020. Almost all respondents considered the HPV vaccine safe with an overall mean value of 8.8, on a scale ranging from 1 to 10, and 59.9% and 32.6% believed that the vaccination was very effective in preventing the related diseases among 12–26 years’ girls and boys. Multivariate logistic regression analysis showed that GPs who had received information about HPV vaccination from scientific journals were more likely to have positive attitude towards the effectiveness of the vaccine in preventing HPV-related diseases in girls between 12–26 years. A large majority (81.5%) of GPs who provided assistance to girls’ patients aged 11–12 years often or always recommend the HPV vaccine to them, and this behavior was more likely to occur in those who believed that the vaccine was very effective in preventing HPV-related diseases in girls between 12–26 years. GPs were more likely to often or always recommend the HPV vaccine to boys aged 11–12 years if they often or always recommended the vaccine to girls aged 11–12 years, if they believed that the vaccine was very effective in preventing HPV-related diseases in boys between 12–26 years, and if they considered the HPV vaccine very safe. GPs should receive information about the HPV immunization to ensure that they routinely communicate with their patient population in order to achieve better coverage rates.

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Human papillomavirus (HPV) prevalence and associated risk factors in women from Curaçao

Cited by 14 publications

References 14 publications

Prevalence and genotype distribution of HPV infection among 214,715 women from Southern China, 2012-2018: baseline surveys prior to mass HPV vaccination

Prevalence and genotype distribution of HPV infection among 214,715 women from Southern China, 2012-2018: baseline surveys prior to mass HPV vaccination

The distribution and prevalence of human papillomavirus in women in mainland China

HPV Vaccination Attitudes and Behaviors among General Practitioners in Italy

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