Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) in non small cell lung cancer

MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs)

“…Human PVs (HPVs) cause 5% of all human solid cancers, including virtually all cervical cancers, 25% of head and neck cancers, and some anal and lung cancers (National Cancer Institute home page; Rautava and Syrjänen, 2012;Stanley, 2012;Sudhoff et al, 2011;Joh et al, 2010;Psyrri and DiMaio, 2008;Desai et al, 2009;Jenson et al, 2001;Saman, 2012;Gillison et al, 2012;Campo, 2002). PVs are highly species-specific, non-enveloped small DNA viruses whose replication is largely restricted to individual anatomical sites (Howley and Lowy, 2007).…”

Molecular diagnosis of a laboratory mouse papillomavirus (MusPV)

“…Because these primer sets are designed to maximize efficiency for detecting a wide range of PVs, their use for type-specific PV detection is not possible. Direct sequencing of the PCR product can be used to determine the specific type of PVs detected (Joh et al, 2010). However, development of unique primer sets can be designed to identify each PV type by PCR, such as for MusPV.…”

Human papillomavirus and lung cancinogenesis: an overview

“…The HPV 16 E6 and E7 transcripts were found (Ciotti et al 2006) in Paraffin-embedded tissue/biopsy tissue/pleural effusion PCR lung tumors; moreover, the expression of E6 was significantly higher in females than in males and in patients with adenocarcinoma (Hsu et al 2009). In addition, the 16, 18, 35, 52, 53 and 11 types as well as integration of HPV 16 genome were found in adenocarcinoma and squamous cell carcinoma (Bohlmeyer et al 1998;Joh et al 2010;Mehra et al 2013). Studies in South America tested for the presence of HPV DNA in lung cancer.…”