MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs)

The Mouse Papillomavirus Infection Model

“…Vaginal infections were later confirmed by other groups [ 8 , 11 ]. We are able to readily establish infections in these disparate mucosal tissues and follow the progress of disease by QPCR examination of viral DNA in lavage samples [ 21 ].…”

“…Several immunocompetent mouse strains including C56BL/6, FVB/NJ, and SKH-1 have been tested for susceptibility to MmuPV1 infections at cutaneous sites [ 8 , 11 , 15 , 17 ]. Both CD4 and CD8 T cells have been found to play a crucial role in the control of papillomavirus infection at these sites, although neither CD4 nor CD8-knockout or -depletion led to visible disease in these immunocompetent mice [ 15 , 17 , 18 ].…”

“…In the few years since it was first reported, MmuPV1 has become a valuable animal papillomavirus because it provides, for the first time, the opportunity to study papillomavirus infections in the context of a small common laboratory animal for which abundant reagents are available and for which many strains exist. Several groups, including our own, have established this mouse model system and have made significant progress in understanding molecular, virological, and immunological mechanisms of MmuPV1 infections in both immunocompromised and immunocompetent hosts [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. In this review, we summarize studies using this mouse papillomavirus model over the past six years and share our perspectives on the value of this unique model system.…”

Genome‐wide association analysis identifies a GLUL haplotype for familial hepatitis B virus‐related hepatocellular carcinoma

“…TEDDM1 is a transmembrane epididymal protein predominately expressed in the epididymis and reportedly associated with signaling pathways involved in early sperm maturation, whereas LINC00272 is a non-protein-coding RNA and RGSL1 is involved in the G-protein signaling regulation with a suggested role in prostate carcinogenesis. 37,38 Familial cancer cases are observed at low frequencies compared with sporadic cancer cases, and this rarity is one of the main impediments for familial-based studies, resulting in lengthy recruitment for a sizable quantity of cases as well as small sample sizes. SLC13A2 is a sodiumcoupled citrate transporter of the solute carrier (SLC) group.…”

“…36 In addition, FOXN1 is a transcription factor responsible for the initiation and maintenance of differentiated thymic epithelial cells and is essential for maintaining a functional immune system. 37,38 Familial cancer cases are observed at low frequencies compared with sporadic cancer cases, and this rarity is one of the main impediments for familial-based studies, resulting in lengthy recruitment for a sizable quantity of cases as well as small sample sizes. To our knowledge, only 6 of the total 2742 GWAS listed in the GWAS Catalog were familial-based studies, of which familial leukemia, prostate, and lung cancer studies with 102, 2511, and 194 familial cases, respectively, were included.…”