Human papillomavirus genotypes in Iranian patients with cervical cancer

Shahsiah, Reza; Khademalhosseini, Morteza; Mehrdad, Nili; Ramezani, Fatemeh; Nadji, Seyed Alireza

doi:10.1016/j.prp.2011.09.011

Cited by 18 publications

(9 citation statements)

References 23 publications

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“…In addition, according to Shahsiah's report patients with HPV-16 and HPV-18 prevalence were 75% and 18.3% respectively, while our study reported 90.66% (41). Perhaps the variety of clinical specimens is a reason for a lower prevalence report in Khorasanizadeh's study and Shahsiah's report.…”

Section: Discussioncontrasting

confidence: 51%

Relevant Allelic Frequency of Gene Polymorphism and Genetic Predisposition of Human Papillomavirus in Patients with Cervical Cancer

et al. 2018

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KEYWORDS ABSTRACT Cervical CancerHuman PapillomavirusAmplification-refractory mutation system p53 geneSingle Nucleotide PolymorphismsBackground and Objectives: The present study investigated the correlation between p53 gene codon 72 polymorphism and 6 other genetic single nucleotide polymorphisms (SNPs) in patients with cervical cancer infected by HPV.Methods: 450 patients with cervical cancer (280 Squamous cell carcinoma and 170 Adenocarcinoma) were followed at hospitals in Iran from Dec. 2014 to Apr. 2015. Moreover, 100 age/sex-matched was used as the control group. HPV was detected by LINEAR ARRAY® HPV Genotyping Test. Allelic frequency of 6 gene polymorphisms was detected by the amplification-refractory mutation system (ARMS).Results: From 450 patients, 408 cases (90.66%) were positive for HPV. Four genotypes were observed as single infections (16, 18, 31, and 45). The most common genotypes were HPV-16 (73.52%), HPV-18 (23.28%), HPV-31 and 45 (3.17%), respectively. 306 samples were arginine-arginine homozygous (70.6% and 71.4% of adenocarcinoma and squamous cell carcinoma, respectively), 70 cases were arginine-proline heterozygous (17.6% of adenocarcinoma and 23.8% of squamous cell carcinoma), and 20 cases were as proline-proline homozygous (11.8% and 4.8% of adenocarcinoma and squamous cell carcinoma, respectively).Conclusion: The prevalence of HPV was 84% and that was the estimation of the Global Burden among Iranian patients with cervical cancer (85% -99%). There was no correlation between mutations in the p53 allele and the size/type of tumors, while we found a correlation between mutations in p53 alleles and age. Therefore, XRCC1 G399A SNP and TP53 G72C SNP were significantly correlated with the cervical cancer.Article Info

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Section: Discussioncontrasting

confidence: 51%

Relevant Allelic Frequency of Gene Polymorphism and Genetic Predisposition of Human Papillomavirus in Patients with Cervical Cancer

et al. 2018

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“…These data suggest the distribution of HPV16 and 18 in cervical lesions might be different from that in other regions of Pakistan, as in South Karachi the prevalence of HPV16 infection has been reported to be associated with 75%–93% of carcinomas whereas HPV18 infection is associated with 4%–6.6% [11,12]. Studies in other countries of a similar cultural background have also reported a high prevalence of HPV16 infection in cervical lesions collected from Iran (76% [22], 75% [23], 67.6% [24]) and Saudi Arabia (65.2% [25]) with a corresponding low HPV18 prevalence. However, another study conducted in Iran showed that HPV18 was more commonly detected in cervical lesions than HPV16 (41% HPV18 positive and 29.5% HPV16 positive) [26].…”

Section: Resultsmentioning

confidence: 99%

Prevalence and Genotyping of High Risk Human Papillomavirus in Cervical Cancer Samples from Punjab, Pakistan

Siddiqa

Zainab

Qadri³

et al. 2014

Viruses

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Cervical cancer is the third most common cause of cancer-related death in women worldwide. Infection with high-risk human papillomavirus (HPV) is established as the cause of cervical carcinoma, therefore, high risk HPV detection may have prognostic significance for the women who are at increased risk of disease progression. The paucity of data on the incidence of cervical cancer in Pakistan makes it difficult to determine disease burden. Even less information is available regarding the prevalent HPV strains in cervical specimens collected from this region. Cervical cancer is a neglected disease in Pakistan in terms of screening, prevention, and vaccination. Identification and accurate genotyping of the virus burden in cancer specimens is important to inform intervention policies for future management of HPV associated disease and to potentially stratify patients dependent on HPV status. In this study, detection and genotyping of HPV types 16 and 18 from 77 cervical specimens were carried out. Consensus primers GP5+/GP6+, which detect 44 genital HPV types, and type specific primers (TS16 and TS18) were used in conjunction with newly designed type specific primers. Using a combination of these methods of detection, a total of 94.81% (95% CI ±4.95) of cervical lesions were positive for HPV. Single infections of HPV16 were detected in 24.68% (95% CI ±9.63) of total samples and HPV18 was found in 25.97% (95% CI ±9.79) samples. Interestingly, a high proportion of samples (40.26%, 95% CI ±10.95) was positive for both HPV16 and 18, indicating a higher incidence of co-infection than previously reported for similar ethnic regions. The HPV genotype of 3.90% of HPV positive samples remained undetected, although these samples were positive with the GP5+/GP6+ primer set indicating infection with an HPV type other than 16 or 18. These data indicate that the overall incidence of high risk HPV infection in cervical cancer and intraepithelial neoplasia specimens in Punjab, Pakistan is in line with the worldwide prevalence, but that the incidence of HPV16 and 18 co-infections in our cohort is higher than that previously reported.

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“…29 Most of these studies, however, are based on normal or abnormal cervical cytology screening results obtained from women visiting the gynecologic institutes 28,29. As most HPV infections are self resolving, these subtypes do not represent the major oncogenic subtypes, as evident from the prevalence of HPV16 and 18 in most of the cervical cancer samples from Pakistan and its neighboring countries, including Iran and Saudi Arabia [30][31][32][33][34][35][36][37][38]. Although most of the studies are in agreement, regional differences within Pakistan are evident.…”

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confidence: 99%

Prevalence of High risk Human Papillomavirus in cervical dysplasia and cancer samples from twin cities in Pakistan

Gul

Murad

Javed

2015

International Journal of Infectious Diseases

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Human papillomavirus genotypes in Iranian patients with cervical cancer

Cited by 18 publications

References 23 publications

Relevant Allelic Frequency of Gene Polymorphism and Genetic Predisposition of Human Papillomavirus in Patients with Cervical Cancer

Relevant Allelic Frequency of Gene Polymorphism and Genetic Predisposition of Human Papillomavirus in Patients with Cervical Cancer

Prevalence and Genotyping of High Risk Human Papillomavirus in Cervical Cancer Samples from Punjab, Pakistan

Prevalence of High risk Human Papillomavirus in cervical dysplasia and cancer samples from twin cities in Pakistan

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