Human papillomavirus genotype distribution among French women with and without cervical abnormalities

Casalegno, Jean-Sébastien; Benchaïb, Mehdi; Carval, Karine Le Bail; Piaton, Éric; Mathevet, Patrice; Mekki, Yahia

doi:10.1016/j.ijgo.2011.01.030

Cited by 12 publications

(14 citation statements)

References 19 publications

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“…Our present HPV burden in normal population was comparable with various countries in Europe (1.4-9.2%) (Clifford et al, 2006b). However, it was lower than those generally observed in France (20.2%) (Casalegno et al, 2011), USA (27%) (Evans et al, 2006) and worldwide (10.5%) (Clifford, et al, 2006a).…”

Section: Discussioncontrasting

confidence: 66%

Detection of Human Papillomavirus DNA in Routine Cervical Scraping Samples: Use for a National Cervical Cancer Screening Program in a Developing Nation

Othman

Othman²

2014

Asian Pacific Journal of Cancer Prevention

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Background: Human papillomavirus is a well-established cause of the development of a variety of epithelial lesions in the cervix. However, as yet, incorporation of HPV testing into cervical cancer screening either as an adjunct or stand alone test is limited due to its cost. We therefore here ascertained the presence and type specificity of human papilloma virus (HPV) DNA in routine cervical scrapings. Materials and Methods: Cervical scrapings were collected from women attending clinics for routine Pap smear screening. HPV-DNA was detected by PCR using MY09/11 and GP5+/GP6+ primer sets and genotyping was accomplished by cycle-sequencing. Results: A total of 635 women were recruited into the study with mean±SD age of 43±10.5 years. Of these 92.6% (588/635) were reported as within normal limits (WNL) on cytology. The presence of HPV infection detected by nested MY/GP+-PCR was 4.4% (28/635). The overall prevalence of high-risk HPV (HR-HPV) in abnormal

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Section: Discussioncontrasting

confidence: 66%

Detection of Human Papillomavirus DNA in Routine Cervical Scraping Samples: Use for a National Cervical Cancer Screening Program in a Developing Nation

Othman

Othman²

2014

Asian Pacific Journal of Cancer Prevention

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“…Considering women with normal cervical cytology, when we compared the overall HPV prevalence among Tunisian women with that from neighboring Northern African countries, we reported that it was higher than that of Algeria (5.3%) [22], but lower than that of Morocco (34.3%) [30]. Additionally, we found relatively high HPV prevalence compared to Arab-Muslim countries from the Middle-East [31–33] but substantially lower than that reported by other studies of the Sub-Saharan countries [34, 35] and Mediterranean Europe [36, 37]. The different origins and characteristics of the studied population (age, lifestyle, and ethnicity) may be the reason of these disparities in HPV prevalence.…”

Section: Discussioncontrasting

confidence: 45%

Human papillomavirus genotypes and HPV-16 variants distribution among Tunisian women with normal cytology and squamous intraepithelial lesions

Ghedira

Mahfoudh

Hadhri³

et al. 2016

Infect Agents Cancer

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BackgroundLittle is known about the epidemiological characteristics of papillomavirus (HPV) infection among North African countries. Herein, we conducted a molecular epidemiological study to investigate prevalence of HPV type and HPV-16 variants among cervical-screened unvaccinated Tunisian women.MethodsCross-sectional study was performed on 494 Tunisian women visiting Women’s Healthcare Centers. HPV-DNA detection was carried out on cervical samples using real-time polymerase chain reaction. HPV genotyping and HPV-16 variants were characterized by direct sequencing of L1 viral capsid gene.ResultsThe overall HPV prevalence was 34% (95% CI: 30–38%) with significantly higher prevalence among women with squamous intraepithelial lesions (SIL) than those with no intraepithelial lesions (NIL) 84% (95% CI: 76–92%) and 24.5% (95% CI: 20–29%) respectively. The distribution of HPV prevalence according to women’s age shows a U-shaped curve and the highest HPV prevalence rates were observed among the youngest (≤25 years; 51.2%, 95% CI: 37–67%) and the oldest women (>55 years; 41.7%, 95% The HPV-16 prevalence was 32.8% (95% CI: 22–45%) among women with SIL and 9.2% (95% CI: 6–12%) among women with NIL. Whereas, the HPV-18 prevalence was 1.3% (95% CI: 0–5%) among women with SIL and 0.3% (95% CI: 0–1%) among women with NIL. Among HPV-16 positive women, European lineage (E) was identified as the predominant HPV-16 variant (85.7%, 95% CI: 76–95%). The frequency of E variant was lower among SIL than among NIL women (81%, 95% CI: 64–99%, and 88%, 95% CI: 77–100%, respectively). Conversely, the African-2 variant frequency was higher among SIL than among NIL women (18%, 95% CI: 1–36% and 6%, 95% CI: 2–14%, respectively). In multivariate analysis, young age was the only risk factor that is independently associated with HPV infection. Moreover, HPV infection and menopause were both found to be independently associated with SIL and HSIL.ConclusionHPV DNA testing should be proposed to young and menopausal Tunisian women. Considering HPV prevalence, only 13% of the Tunisian women could be protected by the bivalent HPV vaccine. These results may be helpful for designing an adapted HPV testing and vaccination program in Tunisia.

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“…Yuce et al (2012) reported HPV prevalence as 25.7 (Yuce et al, 2012) and Eroglu detected a positive rate of 32.5% in Kayseri (Eroglu et al, 2011). Studies from different countries which have all used PCR based methods report rates as 7.8% in Iran (Khodakarami et al, 2012), 10.3% in India (Sauvaget et al, 2011), 19.4% in Portugal (Pista et al, 2011, 35.9% in Italy (Piana et al, 2011) and 64.1% in France (Casalegno et al, 2011). There is a wide range between HPV prevalence rates.…”

Section: Discussionmentioning

confidence: 99%

Human Papilloma Virus Frequency and Genotype Distribution in a Turkish Population

Akçalı

Göker²,

Ecemiş³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Human papillomavirus genotype distribution among French women with and without cervical abnormalities

Abstract: The present data indicate a reduced direct impact of HPV vaccination in the study population owing to a low prevalence of HPV-18 and a high prevalence of HPV-53, HPV-31, and HPV-51.

Cited by 12 publications

References 19 publications

Detection of Human Papillomavirus DNA in Routine Cervical Scraping Samples: Use for a National Cervical Cancer Screening Program in a Developing Nation

Detection of Human Papillomavirus DNA in Routine Cervical Scraping Samples: Use for a National Cervical Cancer Screening Program in a Developing Nation

Human papillomavirus genotypes and HPV-16 variants distribution among Tunisian women with normal cytology and squamous intraepithelial lesions

Human Papilloma Virus Frequency and Genotype Distribution in a Turkish Population

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