Human papillomavirus gene sequences in washed human sperm deoxyribonucleic acid

Chan, Philip J.; Su, Brian C.; Kalugdan, Theresa H.; Seraj, Ibrahim M.; Tredway, Donald R.; King, Alan

doi:10.1016/s0015-0282(16)56719-3

Cited by 47 publications

(33 citation statements)

References 2 publications

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“…HPV have been found in seminal plasma and sperm cells, and expression of certain HPV genes in sperm cells has been observed (Lai et al, 1996). Moreover, sperm washing does not seem to eliminate HPV from semen (Chan et al, 1994;Olatunbosun et al, 2001). However, to our knowledge, the infectious potential of semen has not been documented; this potential remains difficult to establish in the absence of cell culture or animal models.…”

Section: Discussionmentioning

confidence: 94%

HPV seminal shedding among men seeking fertility evaluation in Abidjan, Ivory Coast

Didelot-Rousseau

Diafouka

Yayo

et al. 2007

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 94%

HPV seminal shedding among men seeking fertility evaluation in Abidjan, Ivory Coast

Didelot-Rousseau

Diafouka

Yayo

et al. 2007

Journal of Clinical Virology

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“…HIV) can be transmitted via breast milk, but it seems unlikely that HPVs are present in breast milk since there is no viraemic phase and HPVs are not associated with breast lesions. Certain retroviruses can be transmitted vertically by infecting the gametes and there is one report of HPV DNA sequences in purified human sperm cells [38]: this again seems unlikely given the high degree of tissue specificity of genital HPVs for keratinocytes.…”

Section: Source and Routes Of Infant Infections With Hpvmentioning

confidence: 99%

Transmission of Cervical Cancer-Associated Human Papilloma Viruses from Mother to Child

Cason

Rice²,

Best³

1998

Intervirology

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There is now compelling evidence that persistent infection with certain types of human genital papillomaviruses (HPV) may, after many years, lead to cervical cancer. However, HPV have been detected in asymptomatic women, infants and children. Several studies have demonstrated that infants can acquire high-risk HPV infections from their mothers at birth. Thus, the traditional view that cervical-cancer associated HPV infections are primarily sexually transmitted needs to be re-assessed. Accordingly, the role of mother to child transmission of cancer-associated HPVs may need to be investigated further. These facts are pertinent to those developing prophylactic vaccines to prevent high-risk HPV infections and cervical carcinoma.

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“…Several studies have identified HPV in human semen, mainly from men recruited at fertility or maternity clinics, with a prevalence ranging from 4.5–64.3% [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]. The variability reflects differences in clinical characteristics and limitations in both the number of analyzed study subjects and HPV types.…”

Section: Introductionmentioning

confidence: 99%

Identification of Multiple HPV Types on Spermatozoa from Human Sperm Donors

Kaspersen

Larsen²,

Ingerslev

et al. 2011

PLoS ONE

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Human papillomaviruses (HPV) may cause sexually transmitted disease. High-risk types of HPV are involved in the development of cervical cell dysplasia, whereas low-risk types may cause genital condyloma. Despite the association between HPV and cancer, donor sperm need not be tested for HPV according to European regulations. Consequently, the potential health risk of HPV transmission by donor bank sperm has not been elucidated, nor is it known how HPV is associated with sperm. The presence of 35 types of HPV was examined on DNA from semen samples of 188 Danish sperm donors using a sensitive HPV array. To examine whether HPV was associated with the sperm, in situ hybridization were performed with HPV-6, HPV-16 and -18, and HPV-31-specific probes. The prevalence of HPV-positive sperm donors was 16.0% and in 66.7% of these individuals high-risk types of HPV were detected. In 5.3% of sperm donors, two or more HPV types were detected. Among all identified HPV types, 61.9% were high-risk types. In situ hybridization experiments identified HPV genomes particularly protruding from the equatorial segment and the tail of the sperm. Semen samples from more than one in seven healthy Danish donors contain HPV, most of them of high-risk types binding to the equatorial segment of the sperm cell. Most HPV-positive sperm showed decreased staining with DAPI, indicative of reduced content of DNA. Our data demonstrate that oncogenic HPV types are frequent in men.

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Human papillomavirus gene sequences in washed human sperm deoxyribonucleic acid

Cited by 47 publications

References 2 publications

HPV seminal shedding among men seeking fertility evaluation in Abidjan, Ivory Coast

HPV seminal shedding among men seeking fertility evaluation in Abidjan, Ivory Coast

Transmission of Cervical Cancer-Associated Human Papilloma Viruses from Mother to Child

Identification of Multiple HPV Types on Spermatozoa from Human Sperm Donors

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