Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract

Pintos, Javier; Franco, Eduardo L.; Black, Martin J.; Bergeron, Jean‐Marie; Arella, M.

doi:10.1002/(sici)1097-0142(19990501)85:9%3c1903::aid-cncr4%3e3.0.co;2-6

Cited by 54 publications

(47 citation statements)

References 18 publications

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“…82 The presence of HPV DNA in a significant fraction of OSCC raised the question of whether HPV tumor status affects the outcome of oral cancer. To date, the findings have been inconsistent, with some studies reporting no survival differences 84,87,94 and others clearly stating a reduction in death risk among patients with HPVpositive tumors when compared with those with HPVnegative tumors. 82,83,88,[90][91][92] A large study conducted by Gillison et al 82 has shown that patients with HPVpositive tumors had a 60% reduction in risk of death from cancer and significantly improved disease-specific survival when compared patients with HPV-negative tumors.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…83,84,92 Regarding HPV, this may occur via interaction of p53 with protein E6 encoded by the oncogenic HPV types, mainly HPV-16 and HPV-18, which results in increased ubiquitin-dependent proteolysis of p53. 82,83,[92][93][94] The expression of wild-type p53 in HPV-positive tumors contrasts with the higher frequency of p53 mutation in HPV-negative cases, and this fact seems to be associated with better prognosis in patients with HPV-positive OSSC. 82,83,94 Recently published data on the prevalence of HPV infection in OSCC points to rates between 15% and 30%, but this might be an underestimation; it may ascend to more than 50%.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…82,83,[92][93][94] The expression of wild-type p53 in HPV-positive tumors contrasts with the higher frequency of p53 mutation in HPV-negative cases, and this fact seems to be associated with better prognosis in patients with HPV-positive OSSC. 82,83,94 Recently published data on the prevalence of HPV infection in OSCC points to rates between 15% and 30%, but this might be an underestimation; it may ascend to more than 50%. 84,86,87,89,91 The disparity found in the published data has been associated with variations in collection of samples, the efficiency of the detection procedure, and geographic parameters.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

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Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

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Oral squamous cell carcinoma: Review of prognostic and predictive factors

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Regateiro

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Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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436

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“…Some studies reported that the prognosis of patients is not correlated with the detection of HPV DNA or with the viral physical status (Pintos et al 1999;Badaracco et al 2000). Others, however, observed that patients with HPV-positive HNSCC had a better overall and disease-specific survival than did the HPVnegative group (Ringstrom et al 2002).…”

Section: Absence Of Viral Capsid Protein Expression In Hnsccmentioning

confidence: 99%

Human papillomavirus type 16 in head and neck carcinogenesis

2005

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“…Malignant tumors of the upper aerodigestive tract account for $7% of all cancers worldwide, 1 with squamous cell carcinomas (SCCs) constituting the largest portion among the different tumor entities. 2 Even though a majority of SCCs of the head and neck (HNSCC) seems associated to etiologic factors as carcinogenetic substances in tobacco smoke and alcohol, 3 an increase of especially younger patients without reported misuse of these environmental factors in history has been recognized.…”

mentioning

confidence: 99%

p16^INK4a overexpression predicts translational active human papillomavirus infection in tonsillar cancer

Hoffmann¹,

Ihloff²,

Görögh³

et al. 2010

Intl Journal of Cancer

120

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The causal role of human papillomaviruses (HPV) in squamous cell carcinogenesis of tonsillar cancers (TSCC) depends on the activity of the viral oncoproteins E6 and E7, leading to inactivation of the cellular tumor suppressor p53 and the retinoblastoma gene product pRb. Because of the negative feedback mechanisms, the pRb inactivation causes an increase of the inhibitor of the cyclin-dependent kinases p16 INK4a . In 39 TSCC specimens, genotyping based on the amplification of HPV DNA was carried out using PCR by applying HPV type-specific oligonucleotides. Subsequently, amplicons were hybridised with fluorescence-labeled complementary probes using the Southern blot technology. For HPV E6/E7 mRNA expression, Northern hybridization and RT-PCR were performed, and for p16 INK4a detection, immunohistochemistry was performed. With 21/39 (53%) HPV-positives, the detection rate is within the range that can be expected in TSCC. The E6/E7 oncogene mRNA was detectable in 11 cases, 10 of which showed positive signals after p16 INK4a staining. Albeit the small study group was investigated, the correlation of the HPV DNA status with the p16 INK4a expression was of statistical significance (p 5 0.02). Kaplan-Meier estimations revealed better survival outcome for patients with HPV-positive tumors with detectable E6/E7 mRNA and p16 INK4a overexpression (p 5 0.02, median observation time 29 months). As mRNA expression tests are not routinely available in many clinical diagnostic laboratories, and based on the high correlation of p16 INK4a staining with HPV E6/E7 mRNA expression, in conclusion we suggest for a deeper exploration for the use of p16 INK4a as a surrogate marker with the potential to impact the standard of care of HPV DNA-positive head and neck carcinomas.Malignant tumors of the upper aerodigestive tract account for $7% of all cancers worldwide, 1 with squamous cell carcinomas (SCCs) constituting the largest portion among the different tumor entities. 2 Even though a majority of SCCs of the head and neck (HNSCC) seems associated to etiologic factors as carcinogenetic substances in tobacco smoke and alcohol, 3 an increase of especially younger patients without reported misuse of these environmental factors in history has been recognized. 4 Therefore, an increase in knowledge of other factors such as the infection with human papillomaviruses (HPV) promoting carcinogenesis in especially the latter patient group gains in importance.Epidemiologic data demonstrate HPV DNA prevalences of about 20-30% concerning all anatomical tumor sites of the head and neck region, 4-6 with the SCC of the Waldeyer's tonsillar (squamous cell carcinogenesis of tonsillar cancers, TSCC) ring showing an HPV DNA-positive rate of up to 60% as particularly predestined for an infection with HPV. 4,5,7 Recent data from Sweden describe HPV DNA infections in tonsillar carcinomas in even up to 85% of the investigated patients. 8 HPV DNA-positive HNSCCs, again with accentuation of those derived from the Waldeyer's tonsillar ring, are considered as being ...

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Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract

Cited by 54 publications

References 18 publications

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Human papillomavirus type 16 in head and neck carcinogenesis

p16^INK4a overexpression predicts translational active human papillomavirus infection in tonsillar cancer

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Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract

Cited by 54 publications

References 18 publications

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Human papillomavirus type 16 in head and neck carcinogenesis

p16INK4a overexpression predicts translational active human papillomavirus infection in tonsillar cancer

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Product

Resources

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p16^INK4a overexpression predicts translational active human papillomavirus infection in tonsillar cancer