Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications

Hennessey, Patrick; Westra, William H.; Califano, Joseph A.

doi:10.1177/0022034509333371

Cited by 145 publications

(121 citation statements)

References 85 publications

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“…Squamous cell carcinoma is the most common histologic type in oral cancer, accounting 90% of oral neoplasms (Hennessey et al, 2009). Recent reports suggest an increasing incidence in OSCC in many regions of world.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Gan¹,

Zhang²,

Guo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Gan¹,

Zhang²,

Guo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Oral HPV is mainly associated with oropharynx malignancies. 9 In Brazil, the prognosis of oral cancer is poor. 10 Although the oral cavity can be easily explored visually and tactilely, facilitating the detection of early lesions, 5 the diagnosis of oral cancer, especially squamous cell carcinoma, during the asymptomatic stage is unusual.…”

Section: Introductionmentioning

confidence: 99%

Oral cancer from a health promotion perspective: experience of a diagnosis network in Ceará

et al. 2014

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The aim of this study is to share the experience of implementing a network for the diagnosis of oral cancer by integrating primary, secondary, and tertiary oral health care centers and identifying the possible weaknesses of the process. The study also investigated the risks of exposure to the main risk factors for oral and lip cancer and their most common potentially malignant lesions (PML). A quantitative cross-sectional study was conducted in two different regions, with patients seen at a primary health care facility from August 2010 to July 2011. Patients with oral lesions were referred to dental specialty centers for biopsy. Patients with PML were treated in dental specialty centers, and patients with squamous cell carcinoma (SCC) were referred to tertiary health care facilities. The dentists' knowledge of PML and SCC was assessed by an objective questionnaire. A total of 3,965 individuals were examined, 296 lesions were found, and 73 biopsies were performed, of which 13.7% were diagnosed as PML and 9.6% as SCC. Tobacco use and sunlight exposure were associated with SCC (85.7%) and PML (80%), respectively. In total, 55 dentists were assessed. The lesions most commonly recognized as PML were leukoplakia (74%), erythroplakia (57%), and actinic cheilosis (56%). Most dentists (74%) felt incapable of performing biopsies, most likely because of an anxiety towards oral cancer, and 57% had never performed one. The integration of primary and secondary health care enables the diagnosis of PML and SCC and establishes a diagnosis network. However, the inability of most primary care dentists to identify PML and perform biopsies is a weakness of the diagnostic process.

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“…10 Over the last decade, there has been a significant increase in this cancer among younger individuals, possibly due to increased numbers of infections by the human papillomavirus (HPV). 6,11,12 Head and neck cancer develops as the result of interactions between environmental factors and genetic inheritance, and is therefore multifactorial. Tobacco use associated with alcohol consumption is a well-established risk factor for head and neck cancer.…”

Section: Introductionmentioning

confidence: 99%

Clinical and epidemiological characteristics of patients in the head and neck surgery department of a university hospital

Ruback¹,

Galbiatti²,

Arantes³

et al. 2012

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVES: Head and neck cancer is the fifth most common type of cancer worldwide. The objective of this study was to evaluate the clinical and epidemiological parameters in a head and neck surgery service. DESIGN AND SETTING: Cross-sectional study using patients' records, developed in otolaryngology and head and neck department of a university hospital in the northwest of the state of São Paulo. METHODS: A total of 995 patients in the head and neck surgery service between January 2000 and May 2010 were evaluated. The variables analyzed included: age, gender, skin color, tobacco and alcohol consumption, primary site, staging and histological tumor type, treatment and number of deaths. RESULTS:The disease was more frequent among men (79.70%), smokers (75.15%) and alcohol abusers (58.25%). The most representative sites were oral cavity (29.65%) and larynx (24.12%) for the primary site; squamous cell carcinoma (84.92%) was the most frequent histological type, and surgery (29.04%) and radiotherapy (14.19%) were the most common treatments. CONCLUSION: The cancer that affects patients assisted by the head and neck surgery service occurs mainly men, smokers and alcohol abusers, and the oral cavity and larynx are the sites with the highest incidence. The high rate of patients with stages III and IV indicates late diagnosis by the treatment centers, which reflects the need for prevention education campaigns for early diagnosis of the disease. RESUMO

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Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications

Cited by 145 publications

References 85 publications

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Oral cancer from a health promotion perspective: experience of a diagnosis network in Ceará

Clinical and epidemiological characteristics of patients in the head and neck surgery department of a university hospital

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