Human Papillomavirus and Genital Disease in Men: What We Have Learned from the &lt;b&gt;&lt;i&gt;HIM Study&lt;/i&gt;&lt;/b&gt;

Sichero, Laura; Giuliano, Anna R.; Villa, Luisa L.

doi:10.1159/000493737

Cited by 28 publications

(18 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HPV detection at a single time cannot represent persistent HPV infections. A prospective study found that 66% and 90% of HPV infections would be cleared within 12 and 24 months, respectively, in men [35]. Consecutive HPV testing will be conducted at the 12-month visit to further understand the natural history of HPV infections among MSM attending university.…”

Section: Discussionmentioning

confidence: 99%

Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Fan

Ouyang³

et al. 2020

Vaccines

View full text Add to dashboard Cite

Men who have sex with men (MSM) attending university are a high-risk population for human papillomavirus (HPV) infection and are a neglected population of HPV vaccination programs in China. To provide evidence for HPV vaccination policies, we conducted this study to examine the prevalence and factors associated with anal HPV infection among MSM attending university in China. A self-administered online questionnaire was conducted to collect information on social demographics and sexual behaviors. A self-collected rectal swab specimen was collected to test for 37 HPV types. A total of 426 participants were tested for HPV. The median age was 20 years. HPV prevalence was 37.5% for any type, 29.8% for nine-valent vaccine types, 24.6% for four-valent vaccine types, 11.5% for HPV-16/18, and 15.7% for HPV-6/11. Men enrolled in a technical diploma, living in Northern China, having more than two sex partners, being bottom or versatile in anal sex, and having a human immunodeficiency virus (HIV) testing history were more likely to have positive anal HPV of any type. Our study found a high prevalence of anal HPV infection among MSM attending university in China, with HPV vaccine-preventable types being the most popular types in this group. Thus, our findings highlight the urgency of promoting HPV vaccination among teenage MSM.

show abstract

Section: Discussionmentioning

confidence: 99%

Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Fan

Ouyang³

et al. 2020

Vaccines

View full text Add to dashboard Cite

show abstract

“…19,20 Based on previous studies of mechanisms of transmission and the virus-related carcinogenesis, early diagnosis and treatment of a clinical HPV infection in men is potentially beneficial, once its eradication may reduce the viral reservoir and, as a consequence, reduce the incidence of cervical cancer and other HPV-related diseases. [21][22][23][24] Treatment should be targeted at the clinical manifestations of Despite the disease's high clearance rate, longitudinal studies including patients' partners evaluation based on several diagnostic tools are still needed to increment our knowledge on the disease behavior and its consequences, especially from the oncologic perspective in the mid-and long-term.…”

Section: Discussionmentioning

confidence: 99%

“…Based on previous studies of mechanisms of transmission and the virus‐related carcinogenesis, early diagnosis and treatment of a clinical HPV infection in men is potentially beneficial, once its eradication may reduce the viral reservoir and, as a consequence, reduce the incidence of cervical cancer and other HPV‐related diseases 21‐24 …”

Section: Discussionmentioning

confidence: 99%

Contemporary human papillomavirus genotyping and correlations to peniscopy, cytology, and histopatology on over 1000 males

Truzzi

Silva

Freire

et al. 2020

Diagnostic Cytopathology

View full text Add to dashboard Cite

Objectives: To explore male human papillomavirus (HPV) contemporary genotyping epidemiology and correlations to peniscopy, cytology, and histopatology. Methods: Medical records of patients who had been submitted to HPV infection screening with genotyping, peniscopy, cytology, and histopathology in a period of 2 years were reviewed. Frequency analysis and correlations between the diagnostic tools were established. Results: Genotype of 1132 men resulted in 69.2% (784) positivity for HPV DNA, 78% classified as high risk of oncogenesis. Co-infections occurred in 429 (54.7%) and the most frequently identified types were HPV-6, HPV-42, and HPV-16, in 133 (17%), 94 (12%), and 86 (11%) patients, respectively. Positive/negative predictive values of peniscopy, cytology, and histopathology were 83/31%, 92/32%, and 87/33%, respectively. As a result, though significant, the correlations between genotype and non-molecular tests were poor. Conclusions: In the current contemporary representative male cohort, over two thirds are positive for human HPV DNA, 78% of high risk and with over half co-infections. Though significant, its correlation with non-molecular tests is poor and while the positive predictive values of peniscopy, cytology, and histopatology are between 83% and 92%, their negative predictive values are as low as 31% to 33%.

show abstract

“…There have been over 100 types of HPV identi ed with around 40 strains that are known to affect the anogenital area [3]. Though primarily (90%) HPV genotypes 6 and 11 are known to be associated with external anogenital warts, combined infections with other low-risk (LR) and high-risk (HR) HPV types also occur [4][5][6][7][8][9]. People who are between 18 to 59 years of age are most commonly affected, with the highest frequency reported of 20-35 years.…”

Section: Introductionmentioning

confidence: 99%

Wide Spectrum Analysis of HPV Genotypes in External Anogenital Warts among Hungarian Patients

Rideg

Oszter

Makk

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: External anogenital warts (EGW) are primarily associated with the low-risk Human papillomavirus (HPV) genotype 6 and 11, though coinfection with other low-risk and oncogenic high-risk HPV genotypes also occurs. Though the many studies about HPV-associated disease, the epidemiology, and the prevalence of HPV genotypes associated with EGW are not well characterized. The objective of our study was to determine the incidence of HPV genotypes in a Hungarian cohort diagnosed with EGW.Methods: A total number of 94 patients’ archived formalin-fixed paraffin-embedded (FFPE) blocks were enrolled in our retrospective study. HPV genotypes were determined, applying HPV Direct Flow Chip Test.Results: The overall prevalence of HPV DNA in EGW cases was 100%. 72.34% of the cases were mono while 27.65% were multi infections. Cumulative prevalence of HPV 6 and 11 was 98.93%; while a total of 19.4% of the cases occurred with at least one high-risk genotype. The most frequent HPV genotypes were HPV 6 (86.17%), 11 (12.76%), 42 (6.38%) followed by HPV 40, 56, 59, 66, 73 (3.19%).Conclusion: Data of our study could provide invaluable information concerning the relative frequencies of HPV types in the Hungarian population, enabling improved assessment of the actual and future efficacy of vaccination programs and forecast changes in infection patterns.

show abstract

Human Papillomavirus and Genital Disease in Men: What We Have Learned from the <b><i>HIM Study</i></b>

Cited by 28 publications

References 72 publications

Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Contemporary human papillomavirus genotyping and correlations to peniscopy, cytology, and histopatology on over 1000 males

Wide Spectrum Analysis of HPV Genotypes in External Anogenital Warts among Hungarian Patients

Contact Info

Product

Resources

About