Human papillomavirus and Epstein-Barr virus in the pathogenesis of inverted papilloma and associated sinonasal carcinoma

Abstract

Taking into account the low HPV DNA concentration detected only for types 6 and 11, as well as the immunohistochemical detection of HPV L1 in the tumor stromal lymphocytes and macrophages and some basal epitheliocytes in individual cases, it can be assumed that HPV does not play a crucial role as an etiological factor for IP. PCR revealed oncogenic HPV types 16 and 35 in sinonasal carcinoma associated with IP only in one case, which makes it untimely to claim that this virus plays a very special role in the etiology of this carcinoma. Epstein-Barr virus was not found in any case.

HPV‐Positive Status Is an Independent Factor Associated With Sinonasal Inverted Papilloma Recurrence

“…8 Likewise, Bakhtin et al concluded that HPV did not play a crucial role in the etiology of inverted papilloma. 28 The present study results were consistent with those previously published, but our findings revealed that HPV was associated with recurrent SNIP.…”

Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma

“…Although the relationship of HPV infection to malignant transformation remains somewhat controversial [68,82], a recent meta-analysis by Zhao et al found a close association between HPV infection and malignancy, with a pooled odds ratio of 2.16 [83]. Furthermore, high-risk subtypes HPV-16, HPV-18, and HPV-16/18 coinfection had even stronger correlations, with odds ratios of 8.8, 8.04, and 18.57 respectively.…”