Human Papillomavirus and Diseases of the Upper Airway: Head and Neck Cancer and Respiratory Papillomatosis

Gillison, Maura L.; Alemany, Laia; Snijders, Peter J.F.; Chaturvedi, Anil K.; Steinberg, Bettie M.; Schwartz, Steven M.; Castellsagué, Xavier

doi:10.1016/j.vaccine.2012.05.070

Cited by 248 publications

(224 citation statements)

References 150 publications

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“…Cancers of the palatine tonsils, the lingual tonsils (base of tongue), the soft palate, and the oropharyngeal wall, collectively oropharyngeal cancers, rank amongst the few cancers with rapid increases in incidence over the past 30 to 40 years in several developed countries (1)(2)(3)(4). Notably, these increases have occurred despite declines in the prevalence of cigarette smoking, an important oropharyngeal cancer risk factor (1,5).…”

Section: Introductionmentioning

confidence: 99%

Tonsillectomy and Incidence of Oropharyngeal Cancers

Chaturvedi

Song

Rosenberg

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Rising incidence of oropharyngeal cancers in numerous countries since the 1970s has been attributed to increased oral human papillomavirus (HPV) exposure. However, the contribution of coincidental declines in the surgical removal of the tonsils (tonsillectomy) is unknown. We quantified the association of tonsillectomy with risk of tonsillar, other oropharyngeal, and other head and neck cancers and the contribution of declines in tonsillectomies to cancer incidence trends.Methods: We conducted a nation-wide cohort study in Sweden (1970Sweden ( -2009. Tonsillectomies (N ¼ 225,718) were identified through national patient registers, which were linked with the cancer register. Cancer incidence in the tonsillectomy cohort was compared with Sweden's general population through standardized incidence ratios (SIR).Results: Tonsillectomies were associated with reduced risk of tonsil cancers [SIRs 1þ years post-tonsillectomy ¼ 0.31; 95% confidence interval (CI), 0.08-0.79 and 5þ years post-tonsillectomy ¼ 0.17; 95% CI, 0.02-0.62], but unrelated to other oro-

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Section: Introductionmentioning

confidence: 99%

Tonsillectomy and Incidence of Oropharyngeal Cancers

Chaturvedi

Song

Rosenberg

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In China, although there lacks systematic analysis of the incidence trend of HPVpositive OSCC, HPV infection was recently detected in 17% of OSCCs from China (5), close to 18% to 36% in most studies from developed countries (6)(7)(8). Compared with OSCC caused by smoking and drinking, HPVpositive OSCC represents a distinct molecular and clinicopathologic disease entity with a favorable prognosis (3,5,9).…”

Section: Introductionmentioning

confidence: 99%

Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009–2011

Hang

Liu

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Despite the established link between oral human papillomavirus (HPV) infection and a subset of oropharyngeal squamous cell carcinoma (OSCC), little is known about the epidemiology of oral HPV infection among healthy adults in China.Methods: Oral swab specimens and questionnaires were collected from 5,410 individuals (ages 25-65 years). HPV DNA in oral exfoliated cells was tested by general primer-mediated (SPF1/GP6þ) PCR and sequencing. Univariate and multivariate analyses were performed to assess the associations between exposure factors and oral infection.Results: Alpha mucosal HPV types were detected in 0.67% [95% confidence interval (CI), 0.47%-0.93%] of 5,351 b-globin-positive specimens, and cutaneous HPV in 5.46% (95% CI, 4.86%-6.10%). HPV 16 and 3 were the most prevalent types of a mucosal (0.43%; 95% CI, 0.27%-0.64%) and cutaneous HPV (4.17%; 95% CI, 3.65%-4.74%), respectively. The prevalence of a mucosal HPV decreased with increasing age (25-65 years) from 0.93% to 0.36% (P trend ¼ 0.033), and was associated with self-reported history of oral disease [adjusted odds ratio (OR), 4.78; 95% CI, 1.07-21.41]. In 1,614 heterosexual couples, cutaneous HPV in one partner was found to increase the other partner's risk of cutaneous HPV infection (adjusted OR, 2.33; 95% CI, 1.22-4.48).Conclusions: Oral HPV infection, particularly with a mucosal types, is rare among healthy adults in China. A younger age and a history of oral disease imply higher risk of a mucosal HPV infection.

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“…HPVassociated OSCCs tend to be poorly differentiated with basaloid features in histology, frequently presenting at an advanced stage. Patients with HPV-positive OSCC often have an improved survival compared with HPV-negative OSCC patients (Fakhry et al, 2008;Psyrri et al, 2008;Pai et al, 2009;Gillison et al, 2012).…”

Section: Introductionmentioning

confidence: 99%