Human papillomavirus 42–associated digital papillary adenocarcinoma

Cascardo, Camilla; Cornell, Georgeanne E.; Moesch, John R.

doi:10.1016/j.jdcr.2022.10.038

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…In conclusion, our study supports previous studies suggesting an association between DPA and LR-HPV and possibly BRAF p.V600E [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Notably, LR-HPV positivity by ISH may aid in the diagnosis of DPA, but the LR-HPV findings should be interpreted alongside other clinical and histological findings and should not be used as the sole deciding factor.…”

Section: Discussionsupporting

confidence: 92%

“…To differentiate the two, a panel of immunohistochemical (IHC) studies have been suggested to identify luminal and myoepithelial cells [ 3 , 7 ]. Recent studies have shown a strong association between DPA and human papillomavirus 42 (HPV 42), a low-risk HPV (LR-HPV) subtype, by molecular studies and have demonstrated diffuse positivity for HPV 42 by in situ hybridization (ISH) in cases of DPA [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Other studies showed that a subset of DPA cases were associated with BRAF mutations [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases

Chen,

Nagarajan,

Aung

2024

Dermatopathology

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Digital papillary adenocarcinoma (DPA) is a rare malignant neoplasm which arises from the sweat glands and has metastatic potential. DPA exhibits a wide range of architectural features and exhibits low-grade to high-grade features, so distinguishing DPA from benign skin neoplasms, including acral hidradenoma, poses significant diagnostic challenges. The recent literature suggests a strong association between DPA and human papillomavirus (HPV) 42, a low-risk HPV (LR-HPV) subtype, and a possible association between DPA and BRAF p.V600E. To explore these associations, we assessed the utility of in situ hybridization (ISH) for LR-HPV (types 6, 11, 40, 42, 43, 44) and immunohistochemistry (IHC) for BRAF p.V600E in diagnosing DPA and distinguishing DPA from acral hidradenoma. With institutional review board approval, we retrospectively identified 15 specimens of DPA (from 13 patients) and 3 cases of acral hidradenoma. Of the 13 DPA cases, 6 were negative for LR-HPV and BRAF p.V600E; 6 were positive for only LR-HPV; and 1 was positive for only BRAF p.V600E but negative for LR-HPV. All three cases of acral hidradenoma were negative for LR-HPV and BRAF p.V600E. As our sample size is limited, larger studies are needed to assess the value of detecting LR-HPV and BRAF p.V600E in the distinction of DPA and acral hidradenoma. However, our findings indicate a stronger association of DPA with LR-HPV than with BRAF p.V600E.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases

Chen,

Nagarajan,

Aung

2024

Dermatopathology

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Panviral metagenomic sequencing provides further evidence for human papillomavirus 42 association with digital papillary adenocarcinoma

Tekin,

Enninga,

Norgan

et al. 2024

Human Pathology

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A rare tumour – metastatic digital papillary adenocarcinoma: literature review, clinical case of successful therapy

Makarova,

Davydova,

Bogush-Vishnevskaya

et al. 2024

Sib. onkol. ž.

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Digital papillary adenocarcinoma (DPA ) is a rare malignant neoplasm of sweat glands, which was first described by Helwig in 1979 and then classified by Kao in 1987. This disease most often occurs in men aged 50–70 years and is characterized by a relatively favorable prognosis. In most cases, radical excision of the tumor leads to cure. However, 14–47 % of patients develop distant metastases with predominant lung involvement (70 %). The study of etiology and pathogenesis of this rare cancer and its molecular genetic profile seems to be interesting. Currently, there is no clear approach to the treatment of metastatic DPA , but sporadic cases of using chemotherapy have been reported. Aim of the study: to analyze current data on the pathogenesis of DPA , diagnostic features and treatment methods used, as well as to present the first clinical case of treatment of disseminated digital carcinoma with immune checkpoint inhibitors described in scientific literature. Material and Methods. A search of available literature published in Medline, Pubmed, etc. databases from 1984 to 2023 was performed, 21 sources were included in this review. Clinical Case Description. We present a rare case of metastatic digital papillary carcinoma in a 23-year-old male with disease manifestation at the age of 14 years. Lack of vigilance and awareness of oncologists and morphologists did not allow timely diagnosis of malignancy, even in case of 3 local recurrences of the disease. Only biopsy of a metastatic lung nodule with histological and IHC examination (of archival and new material) made it possible to make a correct diagnosis. This case revealed 2 potential targets that could be used for disease control: androgen receptor positive expression and PD -L1 expression with CPS =20. The use of immune response checkpoint inhibitors (ipilimumab + nivolumab) resulted in partial response followed by stable disease.

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Human papillomavirus 42–associated digital papillary adenocarcinoma

Cited by 3 publications

References 5 publications

Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases

Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases

Panviral metagenomic sequencing provides further evidence for human papillomavirus 42 association with digital papillary adenocarcinoma

A rare tumour – metastatic digital papillary adenocarcinoma: literature review, clinical case of successful therapy

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