Panviral metagenomic sequencing provides further evidence for human papillomavirus 42 association with digital papillary adenocarcinoma

Tekin, Burak; Enninga, Elizabeth Ann L.; Norgan, Andrew P.; Erickson, Lori A.; Vanderbilt, Chad; Gupta, Sounak; Guo, Ruifeng

doi:10.1016/j.humpath.2023.10.004

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…In conclusion, our study supports previous studies suggesting an association between DPA and LR-HPV and possibly BRAF p.V600E [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Notably, LR-HPV positivity by ISH may aid in the diagnosis of DPA, but the LR-HPV findings should be interpreted alongside other clinical and histological findings and should not be used as the sole deciding factor.…”

Section: Discussionsupporting

confidence: 92%

“…To differentiate the two, a panel of immunohistochemical (IHC) studies have been suggested to identify luminal and myoepithelial cells [ 3 , 7 ]. Recent studies have shown a strong association between DPA and human papillomavirus 42 (HPV 42), a low-risk HPV (LR-HPV) subtype, by molecular studies and have demonstrated diffuse positivity for HPV 42 by in situ hybridization (ISH) in cases of DPA [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Other studies showed that a subset of DPA cases were associated with BRAF mutations [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases

Chen,

Nagarajan,

Aung

2024

Dermatopathology

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Digital papillary adenocarcinoma (DPA) is a rare malignant neoplasm which arises from the sweat glands and has metastatic potential. DPA exhibits a wide range of architectural features and exhibits low-grade to high-grade features, so distinguishing DPA from benign skin neoplasms, including acral hidradenoma, poses significant diagnostic challenges. The recent literature suggests a strong association between DPA and human papillomavirus (HPV) 42, a low-risk HPV (LR-HPV) subtype, and a possible association between DPA and BRAF p.V600E. To explore these associations, we assessed the utility of in situ hybridization (ISH) for LR-HPV (types 6, 11, 40, 42, 43, 44) and immunohistochemistry (IHC) for BRAF p.V600E in diagnosing DPA and distinguishing DPA from acral hidradenoma. With institutional review board approval, we retrospectively identified 15 specimens of DPA (from 13 patients) and 3 cases of acral hidradenoma. Of the 13 DPA cases, 6 were negative for LR-HPV and BRAF p.V600E; 6 were positive for only LR-HPV; and 1 was positive for only BRAF p.V600E but negative for LR-HPV. All three cases of acral hidradenoma were negative for LR-HPV and BRAF p.V600E. As our sample size is limited, larger studies are needed to assess the value of detecting LR-HPV and BRAF p.V600E in the distinction of DPA and acral hidradenoma. However, our findings indicate a stronger association of DPA with LR-HPV than with BRAF p.V600E.

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