Human Papillomavirus 18 Genetic Variation and Cervical Cancer Risk Worldwide

Chen, Alyce A.; Gheit, Tarik; Franceschi, Silvia; Tommasino, Massimo; Clifford, Gary M.

doi:10.1128/jvi.01747-15

Cited by 86 publications

(92 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To date, there is very little information regarding how HPV 18 E6 variants may affect disease progression, outcome, and/or E6 function. In the few studies that have examined HPV 18 E6 variants in cervical disease, there were no significant associations with disease risk or disease progression . However, certain HPV 18 E6 intratypic variants have been reported to differentially affect gene expression and cellular pathways involved in driving cervical carcinogenesis .…”

Section: Discussionmentioning

confidence: 98%

Genetic variations in human papillomavirus and cervical cancer outcomes

Rader

Tsaih

Fullin

et al. 2019

Intl Journal of Cancer

View full text Add to dashboard Cite

Cervical cancer is driven by persistent infection of human papillomavirus (HPV), which is influenced by HPV type and intratypic variants, yet the impact of HPV type and intratypic variants on patient outcomes is far less understood. Here, we examined the association of cervical cancer stage and survival with HPV type, clade, lineage, and intratypic variants within the HPV E6 locus. Of 1,028 HPV-positive cases recruited through the CerGE study, 301 were in-situ and 727 were invasive cervical cancer (ICC), with an average post-diagnosis follow-up of 4.8 years. HPV sequencing was performed using tumor-isolated DNA to assign HPV type, HPV 16 lineage, clade, and intratypic variants within the HPV 16 E6 locus, of which nonsynonomous variants were functionally annotated by molecular modeling. HPV 18-related types were more prevalent in ICC compared to in-situ disease and associated with significantly worse recurrence-free survival (RFS) compared to HPV 16-related types. The HPV 16 Asian American lineage D3 and Asian lineage A4 associated more frequently with ICC than with in situ disease and women with an intratypic HPV 16 lineage B exhibited a trend toward worse RFS than those with A, C, or D lineages. Participants with intratypic E6 variants predicted to stabilize the E6-E6AP-p53 complex had worse RFS. Variants within the highly immunogenic HPV 16 E6 region (E14-I34) were enriched in ICC compared to in-situ lesions but were not associated with survival. Collectively, our results suggest that cervical cancer outcome is associated with HPV variants that affect virus-host interactions.

show abstract

Section: Discussionmentioning

confidence: 98%

Genetic variations in human papillomavirus and cervical cancer outcomes

Rader

Tsaih

Fullin

et al. 2019

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Apparently, HPV-18 has various variants, which are classified by the region (geographical and ethnic groups). However, the authors have not been able to explain whether HPV-18 tends to be positive in adenocarcinoma or SCC 21 .…”

Section: Discussionmentioning

confidence: 91%

Human Papilloma Virus Type 16 & 18 Gene Identification In Plasma of Cervical Squamous Cell Carcinoma and Adenocarcinoma Patients Athaji Adam Malik General Hospital Medan

Asmiati¹,

Delyuzar²,

Hidayat³

2018

IJCTR

View full text Add to dashboard Cite

Cervical cancer, the forth most common cancer leading cause of death by HPV infection and the most common sexually transmitted infection. HPV type 16 & 18 are responsible for up to 70% cervical cancer compared to another high-risk group type. The aim of this study was to identify gene HPV type 16 & 18 in the plasma patients according to histopathology of squamous cell carcinoma and adenocarcinoma cervix. This descriptive study with cross sectional study from 46 cervical cancer blood patients. Gene HPV identification using polymerase chain reaction (PCR) methods. Majority of samples (80.4%) were infected with HPV-18, but none of them were infected with HPV-16. Most of them were commonly diagnosed squamous cell carcinoma (81.8%) and they generally aged >45 years old. From 13% of cervical cancer patients with metastases, all of them were infected with HPV 18. Detection of HPV type in cervical cancer is important, because HPV 16 and 18 is not always founds in squamous cell carcinoma and adenocarcinoma cervix.

show abstract

“…Regarding staging and tumor size, both HPV 18 lineage A and B tumor samples was primarily staging 2 and 3 with tumor size up to 7 cm. (8,11,14). Speci c variations of HPV 18 may present high oncogenic potential and in uence the variation of distribution of cervical cancer in different regions (20).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to classi cation in variants (up to 10% divergence), there is the classi cation into sublineages, when a divergence of 0.5 to 1% occurs between the same variant. For HPV 18, the sublineages are classi ed into: variant A (A1, A2, A3, A4 and A5), variant B (B1, B2 and B3), and variant C (has no sublineages) (11).…”

Section: Introductionmentioning

confidence: 99%

HPV 18 Variants in Women with Cervical Cancer in Northeast Brasil

Santos¹,

Cunha²,

Batista³

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: Human Papillomavirus (HPV) is the main etiological factor for the development of cervical cancer. HPV 18 is the second most frequent, accounting for up to 65% of all cases. HPV intratypic variation may influence the potential for progression to invasive cancer.The aim of this study was to evaluate the prevalence of human papillomavirus 18 intratypic variants in cervical cancer samples from women in the Northeast of Maranhão. Methods: The study was composed of 118 women over 18 years of age with a diagnosis of cervical cancer. Tumor fragments were collected and subjected to DNA extraction and Polymerase Chain Reaction (PCR) for HPV detection using the PGMY09/11 and GP+5/6 primers. Positive samples were submitted to automated sequencing for viral genotyping. To determine the HPV 18 lineages, positive samples were submitted to PCR, using specific primers to amplify the LCR and E6 regions of HPV 18 virus. Results: HPV was present in 88 women (73.3%), and HPV 16 was the most prevalent (48/54%), followed by HPV 18 (12/13.6%). Histologically, squamous cell carcinoma was predominant (79.1%). Among the HPV 18 variants identified, 10 (80%) belonged to lineage A, and sublineages A1, A2, A3, and A4. HPV 18 B variant (2/29%) was also detected, with the sublineages B1 and B2. In this study, the C variant was not found. There was no statistically significant association between the HPV 18 lineages found and sociodemographic and lifestyle variables (p > 0.05). Conclusions: Women with cervical cancer are associated with a higher frequency of HPV 16 and 18 in the Northeast region of Brazil, with a high prevalence of the lineage A among women with HPV 18.

show abstract

Human Papillomavirus 18 Genetic Variation and Cervical Cancer Risk Worldwide

Cited by 86 publications

References 59 publications

Genetic variations in human papillomavirus and cervical cancer outcomes

Genetic variations in human papillomavirus and cervical cancer outcomes

Human Papilloma Virus Type 16 & 18 Gene Identification In Plasma of Cervical Squamous Cell Carcinoma and Adenocarcinoma Patients Athaji Adam Malik General Hospital Medan

HPV 18 Variants in Women with Cervical Cancer in Northeast Brasil

Contact Info

Product

Resources

About