Human papillomavirus-16 presence and physical status in lung carcinomas from Asia

Abstract

BackgroundAlthough human papillomavirus (HPV) genome has been detected in lung cancer, its prevalence is highly variable around the world. Higher frequencies have been reported in far-east Asian countries, when compared with European countries. The present study analysed the HPV-16 presence in 60 lung carcinomas from the Asian countries China, Pakistan and Papua New Guinea.ResultsHPV-16 was present in 8/59 (13%) samples. According to histological type, HPV-16 was detected in 8/18 (44%) squamous cell carcinomas (SQCs), which were mainly from Pakistan; 0/38 (0%) adenocarcinomas (ACs), which were mainly from China; and in 0/4 (0%) small cell carcinomas (SCLCs). The observed histological difference was statistically significant (p < 0.001). HPV-16 viral load was also determined using real-time polymerase chain reaction (qRT-PCR); it ranged between 411 to 2345 copies/100 ng of genomic DNA. HPV-16 genome was found integrated into the host genome in every HPV-16 positive carcinoma.ConclusionThese results support the notion that HPV-16 infection is highly associated with SQCs in Pakistan. Our results show a frequent HPV-16 integration in SQCs, although the low viral load casts doubt respect a direct etiological role of HPV in lung carcinomas from Asia. Additional HPV-16 characterization is necessary to establish a direct or indirect etiological role of HPV in this malignancy.

Prevalence of human papillomavirus, Epstein‐Barr virus, and cytomegalovirus in fine needle aspirates from lung carcinoma: A case–control study with review of literature

“…10,11,26,27 In the present study too, we observed a significant association of SCC with HPV (P 5 0.01). 10,11,26,27 In the present study too, we observed a significant association of SCC with HPV (P 5 0.01).…”

“…Although HPV has been found to be associated with all histological subtypes of lung cancer; the association is strongest with SCC. 10,11,26,27 In the present study too, we observed a significant association of SCC with HPV (P 5 0.01).…”

Detection of Merkel cell polyomavirus with a tumour-specific signature in non-small cell lung cancer

“…For instance, human papillomavirus (HPV) infection has been observed in association with cases of lung cancer in many studies worldwide, suggesting a role for HPV as an aetiological agent of lung cancer (Aguayo et al , 2007; Klein et al , 2009; Rezazadeh et al , 2009; Prabhu et al , 2012). However, the results are discrepant among research groups (Brouchet et al , 2005) and underline some geographical variations (Miyagi et al , 2000; Aguayo et al , 2010; Goto et al , 2011). …”

Human papillomavirus prevalence in lung carcinomas in Bulgaria

“…Aguayo et al . observed statistically significant differences in HPV 16 prevalence between histological cancer types: they detected HPV16 in 44% SCCs, whereas ACs and SmCCs were HPV16 negative . A Chinese study found that HPV infection is more prevalent in SCC (59.8%) than in AC (17.5%) .…”