Human Papillomavirus–16 E6 Variants in Cervical Squamous Intraepithelial Lesions From HIV-Negative and HIV-Positive Women

Pérez-Gallego, Lucía; Moreno‐Bueno, Gema; Sarrió, David; Suárez, Alvaro; Gamallo, Carlos; Palacios, José

doi:10.1309/42u5-q2ev-rcbm-wpgj

Cited by 12 publications

(11 citation statements)

References 27 publications

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“…These small studies have reported conflicting results regarding the effects of HIV coinfection on the distribution of HPV variants and the studied region (7). Icenogle et al (15), in Africa, and Perez-Gallego et al (24), in Spain, had similar results and did not observe any difference in the prevalence of European variants by HIV status.…”

Section: Gheit Et Almentioning

confidence: 68%

“…HPV16 variants were more frequent than the prototype in all published studies concerning cervical carcinoma, although the prevalence of variants differs among geographic regions. The distribution of the HPV16 E6 European prototype has been described as being present in 9-47% of cervical cancer (21,35,38,39) and in 44-62% of high-grade lesions (18,21,24,39). European variants were described in 15-65% of cervical cancer (21,35,38,39) and in 24-37% of HSIL (18,21,24,39).…”

Section: Discussionmentioning

confidence: 99%

“…Worldwide, very few studies referring to the prevalence of HPV16 European variants in HIV-positive women have been published (7,15,20,24,27). These small studies have reported conflicting results regarding the effects of HIV coinfection on the distribution of HPV variants and the studied region (7).…”

Section: Gheit Et Almentioning

confidence: 99%

“…In addition, the rate of incident HPV infection is reported to be at least three times higher in HIV-positive women (22). However, little is known about HPV16 variant distribution in low-grade SIL (LSIL) and particularly in HIV-positive women (7,20,24).…”

Section: Introductionmentioning

confidence: 99%

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HPV16 Variants in Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Negative and –Positive Brazilian Women

Gheit

Simões²,

Tommasino³

et al. 2006

Viral Immunology

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Emerging evidence supports the role of human papillomavirus (HPV) intratype variations in the development of cervical lesions in immunocompetent women, but few studies investigated HPV16 variants in human immunodeficiency virus (HIV)-positive women. This is the first study in Brazil evaluating HPV16 variants in women with (n = 19) and without (n = 22) HIV infection, as well as cervical lesions. Although non-European variants presented an almost 3-fold increase (13.6% vs. 36.8%) among HIV-positive women, associations between HPV16 variants and HIV infection did not reach statistical significance (Fisher's exact test, p = 0.15). No associations were found between non-European variants and HSIL (Fisher's exact test, p = 0.41), although a significant association was observed between European variants and HSIL among HIV-negative women (Fisher's exact test, p = 0.01). In conclusion, in HIV-negative women the HPV16 European variants seem to influence the occurrence of HSIL, whereas in HIV-positive women, similar roles are atributted to both variants.

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Section: Gheit Et Almentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Gheit Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HPV16 Variants in Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Negative and –Positive Brazilian Women

Gheit

Simões²,

Tommasino³

et al. 2006

Viral Immunology

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“…Additionally, highly oncogenic HPV16 and 18 variants might be expected to have a particularly aggressive natural history in the presence of diminished host immune status, such as in HIV-positive women [5][6][7][8]. Women with human immunodeficiency virus (HIV)/ AIDS are at elevated risk of cervical cancer, as shown by studies of population-based US AIDS and cancer registries [9,10].…”

Section: Introductionmentioning

confidence: 99%

Genotypic Distribution of Different Variants of Oncogenic Human Papilloma Virus (HPV) among the Sexually Active HIV-1 Positive Female Population from Manipur, India

Mullick¹,

Sengupta²,

Sarkar³

et al. 2012

WJA

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A total of 531 sexually active female populations from Manipur (north-eastern India), was chosen for this study. Out of 531 females from Manipur, 111 (20.9%) were HIV positive and 420 were HIV negative (79%). PCR amplification of the MY region of the HPV L1 gene using consensus MY09/11 primer showed 3.7% positivity in Manipur. Interestingly HPV infection among the HIV infected population from Manipur was found to be higher (9%) compared to the non HIV infected population from Manipur (3.7%). Further, single PCR for detecting the 16/18 genotypes and multiplex PCR for the other high risk groups showed equal prevalence of 16 and 18 and other high risk groups (1.3% each) in Manipur. This result was further confirmed by the sequencing and phylogenetic analysis. Thus, our study showed fairly high HPV prevalence rate among the HIV infected population compared to the non HIV cases in Manipur and also equal prevalence of 16/18 genotypes with other high risk groups. According to our knowledge this is the first kind of a genotypic study among the HPV-HIV co-infected population from northeastern states of India.

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Human papillomavirus type 16 variants in cervical cancer from an admixtured population in Brazil

Junes-Gill

Sichero²,

Maciag³

et al. 2008

Journal of Medical Virology

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Several studies indicate that molecular variants of HPV-16 have different geographic distribution and risk associated with persistent infection and development of high-grade cervical lesions. In the present study, the frequency of HPV-16 variants was determined in 81 biopsies from women with cervical intraepithelial neoplasia grade III or invasive cervical cancer from the city of Belem, Northern Brazil. Host DNAs were also genotyped in order to analyze the ethnicity-related distribution of these variants. Nine different HPV-16 LCR variants belonging to four phylogenetic branches were identified. Among these, two new isolates were characterized. The most prevalent HPV-16 variant detected was the Asian-American B-2, followed by the European B-12 and the European prototype. Infections by multiple variants were observed in both invasive cervical cancer and cervical intraepithelial neoplasia grade III cases. The analysis of a specific polymorphism within the E6 viral gene was performed in a subset of 76 isolates. The E6-350G polymorphism was significantly more frequent in Asian-American variants. The HPV-16 variability detected followed the same pattern of the genetic ancestry observed in Northern Brazil, with European, Amerindian and African roots. Although African ancestry was higher among women infected by the prototype, no correlation between ethnical origin and HPV-16 variants was found. These results corroborate previous data showing a high frequency of Asian-American variants in cervical neoplasia among women with multiethnic origin.

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Human Papillomavirus–16 E6 Variants in Cervical Squamous Intraepithelial Lesions From HIV-Negative and HIV-Positive Women

Cited by 12 publications

References 27 publications

HPV16 Variants in Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Negative and –Positive Brazilian Women

HPV16 Variants in Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Negative and –Positive Brazilian Women

Genotypic Distribution of Different Variants of Oncogenic Human Papilloma Virus (HPV) among the Sexually Active HIV-1 Positive Female Population from Manipur, India

Human papillomavirus type 16 variants in cervical cancer from an admixtured population in Brazil

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