Human Papilloma Virus in Hyperplastic Tonsillar and Adenoid Tissues in Children

Abstract

Although the significance of the presence of HPV DNA in tonsillar and adenoid hyperplasias remains obscure, the PCR detection of high-risk HPV DNA should be evaluated cautiously.

Human papilloma virus (HPV) infection in children and adolescents

“…HPVs, including 'high-risk' mucosal HPVs 16 and 18, have also been detected in tonsillar or adenoid samples from children with normal mucosa, tonsillar hyperplasia, chronic tonsillitis, or adenoid hyperplasia [9,30,63].…”

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

“…A Greek study determined the presence of HPV DNA in children. They found 9 of 106 tonsils to be HPV-positive, with six cases having HPV-16, two cases having HPV-11 and one case having an untyped HPV (Mammas et al, 2006). Another study reported HPV-16 infection in 13 of 206 tonsils (6.3%) with 11 cases from children or young adults aged less than 25 years (Chen et al, 2005).…”

Implications of Human Papillomavirus Infections in the Biology of Head and Neck Cancers

“…A Greek study determined the presence of HPV DNA in children. They found 9 of 106 tonsils to be HPV-positive, with six cases having HPV-16, two cases having HPV-11 and one case having an untyped HPV (Mammas et al, 2006). Another study reported HPV-16 infection in 13 ofprevalence or no prevalence of oncogenic and non-oncogenic HPV was identified in the specimens studied (Brandsma & Abramson, 1989;Ernster et al, 2009;Klingenberg et al, 2010;Klussmann et al, 2001;Niedobitek et al, 1990;Ribeiro et al, 2006;Sisk et al, 2006;Snijders et al, 1992).…”