Human papilloma virus and genitourinary cancers: a narrative review

Cai, Tommaso; Vico, T. Di; Durante, Jacopo; Tognarelli, Alessio; Bartoletti, Riccardo

doi:10.23736/s0393-2249.18.03141-7

Cited by 23 publications

(23 citation statements)

References 48 publications

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“…It has been estimated that microbiota may be associated with more than 20% of malignancies [ 35 ], but the role of only few microorganisms as carcinogens is widely known and well established. Among the few, one has to include Helicobacter pylori (gastric cancer), Schistosoma haematobium (urinary BC), and human papilloma viruses (cervical and penile cancers) [ 36 , 37 , 38 , 39 , 40 , 41 ]. Studies of the gut, pancreatic, and breast microbiome revealed a multifactorial association between microbiota and cancer [ 35 , 42 , 43 ] and, although the mechanisms of the microbiome interaction with human cells are extremely complex, they involve at least one of these three phenomena: direct influence on host cells’ proliferation and death, modulation of innate immune system, and interaction with host biochemistry [ 44 ].…”

Section: Microbiota and Tumorigenesismentioning

confidence: 99%

Urobiome in Gender—Related Diversities of Bladder Cancer

Bilski¹,

Dobruch²,

Kozikowski³

et al. 2020

IJMS

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Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecular background, another related concept which has been speculated to contribute to gender diversities in BC is the role of urinary pathogens in bladder carcinogenesis. Microbiome studies, fueled by the availability of high-throughput DNA-based techniques, have shown that perturbation in the microbiome is associated with various human diseases. The aim of this review is to comprehensively analyze the current literature according to sex-related differences in the microbiome composition in BC.

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Section: Microbiota and Tumorigenesismentioning

confidence: 99%

Urobiome in Gender—Related Diversities of Bladder Cancer

Bilski¹,

Dobruch²,

Kozikowski³

et al. 2020

IJMS

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“…Regarding urological cancers, viral infections seem to play a marginal role [ 9 ]. The strong association was proven only for human papilloma virus (HPV) and penile cancer risk [ 10 ]. However, more and more research shows a possible link between viral infections and urothelial cancer [ 11 , 12 , 13 , 14 , 15 ], prostate cancer [ 15 , 16 , 17 ] or testicular cancer [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Epstein-Barr Virus and Human Adenovirus Viremia in Renal Tumors Is Associated with Histological Features of Malignancy

Kryst

Poletajew

Wyczalkowska-Tomasik

et al. 2020

JCM

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Background: There is growing evidence that viral infections may impact the risk and clinical course of malignancies, including solid tumors. The aim of this study was to assess the possible association of selected chronic/latent viral infections with the clinical course of renal cell carcinoma (RCC). Methods: In this prospective study we enrolled 27 patients undergoing partial or radical nephrectomy due to the histologically confirmed RCC and followed them up for one year post-operation. Isolation of the nucleic acids was performed using the NucleoSpin Tissue Kit (Macherey-Nagel, Düren, Germany) from tumor tissue and using the EZ1 Virus Mini Kit v2.0 from plasma. The number of viral copies of human adenovirus (ADV), herpes simplex virus HSV-1 and HSV-2, Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK virus (BKV) and John Cunningham virus (JCV) in the tissue and plasma was assessed with real-time PCR. Results: Viral infections were diagnosed in ten patients (37.0%), including three ADV cases (11.1%) and eight EBV cases (29.6%). Infected patients tended to be significantly older (71.3 vs. 57.6 years, p < 0.05), more commonly presented with chronic renal disease (OR 2.4, p < 0.05), diabetes (OR 4.2, p < 0.05) and overweight (OR 2.0, p < 0.05). Regarding oncological data, infected patients were found to have a higher rate of high-grade cancers (OR 5.0, p < 0.05) and a higher rate of papillary RCCs (OR 8.3, p < 0.05). Status of viral infections had no influence on the clinical cancer stage, surgical procedure or survival. Conclusions: EBV and ADV infections are common in renal cancer patients and increase the risk of high-grade RCC presence. While there is no significant impact on short term survival, further studies are needed to assess the relevance of these findings in a long run.

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“…In addition, 60.7% of study specimens were HNC from oral cavity or larynx, which are driven more by alcohol and smoking than HPV [4]. Furthermore, HPV prevalence rate in cervical cancer biopsies appear lower than that reported in other studies [16], suggesting possible low detection sensitivity due to the storage protocol of biopsy samples into paraffin, as mentioned elsewhere [17].…”

mentioning

confidence: 99%

Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study

Kofi¹,

Mossoro-Kpinde²,

Bouassa³

et al. 2019

Infect Agents Cancer

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We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0.74% (95% CI: 0.0–2.2). Among the 29 cervical cancer samples, 19 (65.5%; 95% CI: 48.2–82.8) were positive for HPV. These results indicate that HNC are infrequently associated with HPV infection in the Central African Republic.

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Human papilloma virus and genitourinary cancers: a narrative review

Cited by 23 publications

References 48 publications

Urobiome in Gender—Related Diversities of Bladder Cancer

Urobiome in Gender—Related Diversities of Bladder Cancer

Epstein-Barr Virus and Human Adenovirus Viremia in Renal Tumors Is Associated with Histological Features of Malignancy

Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study

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