Human ovarian granulosa cells use clathrin-mediated endocytosis for LDL uptake: immunocytochemical and electron microscopic study

Abdulova, Aynur; Purelku, Merjem; ŞAHİN, Hakan; Tanrıverdi, Gamze

doi:10.1080/01913123.2023.2200532

Cited by 1 publication

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides being internalized by receptors, endocytosis is also used as a means of transporting lipids into the cell cytoplasm. The most well-studied forms of general endocytosis are the ones mediated by clathrin and caveolin (Johannes et al, 2016;Kaksonen and Roux, 2018;Kostarnoy et al, 2022;Abdulova et al, 2023;Liu et al, 2023;Tang et al, 2023;Yu and Yoshimura, 2023). More recently, a new mechanism of lipid transport and uptake, named Mincle-mediated endocytosis (MiMe) was described.…”

Section: Lipid Metabolismmentioning

confidence: 99%

Cell lipid biology in infections: an overview

Prado,

Camara,

Barbosa

2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Lipids are a big family of molecules with a vast number of functions in the cell membranes, within the cytoplasm, and extracellularly. Lipid droplets (LDs) are the most common storage organelles and are present in almost every tissue type in the body. They also have structural functions serving as building blocks of cellular membranes and may be precursors of other molecules such as hormones, and lipoproteins, and as messengers in signal transduction. Fatty acids (FAs), such as sterol esters and triacylglycerols, are stored in LDs and are used in β-oxidation as fuel for tricarboxylic acid cycle (TCA) and adenosine triphosphate (ATP) generation. FA uptake and entrance in the cytoplasm are mediated by membrane receptors. After a cytoplasmic round of α- and β-oxidation, FAs are guided into the mitochondrial matrix by the L-carnitine shuttle system, where they are fully metabolized, and enter the TCA cycle. Pathogen infections may lead to impaired lipid metabolism, usage of membrane phospholipids, and LD accumulation in the cytoplasm of infected cells. Otherwise, bacterial pathogens may use lipid metabolism as a carbon source, thus altering the reactions and leading to cellular and organelles malfunctioning. This review aims to describe cellular lipid metabolism and alterations that occur upon infections.

show abstract