Human ocular angiostrongyliasis: a literature review

Diao, Zongli; Wang, Jing; Qi, Haifeng; Li, Xiaoli; Zheng, Xiongwei; Yin, Chenghong

doi:10.1258/td.2010.100294

“…Thirty-two percent of adult patients had fever, which was mostly low grade; however, approximately 10 % of these had high-grade fever ranging from 38 C to 39 C (Yii 1976;Punyagupta et al 1975). In addition, the clinical features of human ocular angiostrongyliasis in 35 patients involve visual loss (94.3 %), fundus change (34.3 %), eye redness and pain (17.1 %), eye floater (8.6 %), and blindness (5.7 %) (Diao et al 2011).…”

Section: Clinical Aspectsmentioning

confidence: 99%

Angiostrongylus cantonensis in China

Wei

¹

,

Wu

²

2013

Treatment of Human Parasitosis in Traditional Chinese Medicine

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“…Lung pathology caused by A. cantonensis larvae has been reported from computed tomography (CT) scan images of patients with neural angiostrongyliasis in China (Cui et al 2011) and in Australia (Morton et al 2013). Ocular angiostrongyliasis has also been reported in 42 patients from 13 countries, in which the most common sign is loss of vision (Diao et al 2011, Feng et al 2013. Fatal cases of encephalitis due to Angiostrongylus have also been reported in humans (Sawanyawisuth and Kitthaweesin 2008, Lv et al 2009, Sawanyawisuth et al 2009, Morton et al 2013.…”

Section: Introductionmentioning

confidence: 99%

Emergence of Neural Angiostrongyliasis in Eastern Australia

Aghazadeh

¹

,

Jones

²

,

Aland

³

et al. 2015

Vector-Borne and Zoonotic Diseases

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Despite an apparent increase in cases of angiostrongyliasis in humans and animals in Australia, the epidemiology of infection with the two species of Angiostrongylus that co-exist in this country, namely A. cantonensis and A. mackerrasae, is poorly understood. This knowledge gap is particularly important with respect to A. mackerrasae, a species evidently native to Australia, as its ability to cause disease in humans is unknown. Likewise, there is little information on the roles of native and introduced species of rodents and molluscs as hosts of Angiostrongylus species in Australia. This review focuses on the gaps in the knowledge about the two species, highlighting the need for epidemiological and pathogenesis studies on the native lungworm A. mackerrasae.

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“…Although rare, ocular angiostrongyliasis has been reported in 36 patients from 10 countries and the most common sign is loss of vision. After reaching the brain tissue, larvae can migrate along the surface of the brain and at the base of the brain, where they may transverse the optic nerve, travelling between the nerve and sheath until they enter the eye chamber 6 . A fifth stage A.…”

Section: Clinical Signsmentioning

confidence: 99%

“…The nucleotide composition of the mt DNA of A. mackerrasae was 24.42% for A, 20.81% for G, 6.35% for C and 48.42% for T ( Table 2). The mt genome contains 12 protein coding genes (cox1-3, nad1-6, nad4L, atp6and cob), as well as two ribosomal RNA (rRNA) and 22 transfer RNA (tRNA)…”

Section: Characteristics Of Mt Genome Of a Mackerrasaementioning

confidence: 99%

“…Lung pathology caused by A. cantonensis larvae has been reported from CT scan images of patients with neural angiostrongyliasis in China 4 and in Australia 5 . Ocular angiostrongyliasis has also been reported in 42 patients from 13 countries, in which the most common sign is loss of vision 6,7 . Fatal cases of encephalitis due to Angiostrongylus have also been reported in humans 5,8,9,10 .…”

Section: Introductionmentioning

confidence: 99%

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Molecular and pathological studies on Angiostrongylus species in southeast Queensland

Aghazadeh¹

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Despite an apparent increase in cases of angiostrongyliasis in humans and animals in Australia, the epidemiology of infection with the two species of Angiostrongylus that co-exist in this country, namely A. cantonensis and A. mackerrasae, is poorly understood. This knowledge gap is particularly important with respect to Angiostrongylus mackerrasae, a species evidently native to Australia, as its ability to cause disease in humans is unknown.Likewise, there is little information on the roles of native and introduced species of rodents and molluscs as hosts of Angiostrongylus species in Australia. This thesis focuses on the gaps in the knowledge about the epidemiology of two species in southeast Queensland, highlighting the hotspots for transmission of the parasite in urban Brisbane. A comprehensive survey of rats belonging to the species Rattus rattus, Rattus norvegicus and Rattus fuscipes was conducted. The prevalence of infection with Angiostrongylus spp. was 16.5% in Rattus spp. trapped in urban Brisbane and surrounds which is much higher than estimates of earlier studies. This highlights the possible risk of zoonotic infection in children, dogs and wildlife in this region and indicates the necessity for public awareness as well as more detailed epidemiological studies on this parasite in eastern Australia.Of the two Australian species, Angiostrongylus mackerrasae appears to be adapted to life in the native bush rat, Rattus fuscipes. This species evidently has an identical life cycle to that of Angiostrongylus cantonensis. A. mackerrasae may have greater potential to infect non-rodent hosts as it has been found as adult form in the lungs, as has been recorded for an individual flying fox.This raises concerns as to the potential of this native angiostrongylid to infect domestic animals and humans. To date, data on the taxonomy, epidemiology and population genetics of A. mackerrasae are poor or unknown. Here, we describe the mitochondrial (mt) genome of A. mackerrasae with the aim of addressing some of these knowledge gaps.The complete mitochondrial (mt) genome of A. mackerrasae was amplified from a single morphologically identified adult worm, by long-PCR in two overlapping amplicons (8 kb and 10 kb). The amplicons were sequenced using the MiSeq Illumina platform and annotated using an in-house pipeline. Amino acid sequences inferred from individual protein coding genes of the mt genomes were concatenated and then subjected to phylogenetic analysis using Bayesian inference.The mt genome of A. mackerrasae is 13,640 bp in size and contains 12 protein coding genes (cox1-3, nad1-6, nad4L, atp6 and cob), and two ribosomal RNA (rRNA) and 22 transfer RNA (tRNA) genes. The mt genome of A. mackerrasae has similar characteristics to those of other Angiostrongylus species which is explained in detail in chapter 3. Phylogenic comparisons reveal III that A. mackerrasae is closely related to A. cantonensis and the two sibling species may have recently diverged compared with all other species in the genus with a highl...

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Human ocular angiostrongyliasis: a literature review

Cited by 29 publications

References 22 publications

Angiostrongylus cantonensis in China

Angiostrongylus cantonensis in China

Emergence of Neural Angiostrongyliasis in Eastern Australia

Molecular and pathological studies on Angiostrongylus species in southeast Queensland

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