Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations

Abstract

Oura Health Ltd.'s provided the surveillance smart rings for the study, but did not participate in the analysis. The manuscript in question is published as a preprint in bioRxiv, but we guarantee that it does not infringe any subsequent copyright or license agreement. 3We would like to thank all study subjects for their participation in the study. We also thank Tuomas Konttajärvi for assistance in measurements and preprocessing of EEG data, Jani Häkli, Annastiina Kivipää, Tarja Holtinkoski, Aleksi Rasila, Taneli Hautaniemi, Miia Lampinen and others who assisted in measurements or otherwise contributed. We are grateful for devices and data provided by Oura. We wish to acknowledge Jussi Kantola for data management and reconstruction of MREG data, the CSC -IT Center for Science Ltd.

The glymphatic system: Current understanding and modeling

“…Future studies should explore the relative proportion of fluid efflux via perivenous spaces versus white matter tracts; no models of the latter route exist, to the best of our knowledge. Modeling may also provide important evidence for the role of respiration as a glymphatic driving mechanism in perivenous spaces (Abbott, 2004;Kiviniemi et al, 2016;Santisakultarm et al, 2012) and CSF in general (Vinje et al, 2019;Helakari et al, 2022). Finally, future experimental studies could help illuminate whether there is direct efflux from the glymphatic system to the meningeal lymphatics; if so, techniques developed for modeling peripheral lymphatic vessels (Moore and Bertram, 2018;Margaris and Black, 2012) can be adapted to investigate glymphaticlymphatic efflux.…”

Altered spontaneous brain activity during dobutamine challenge in healthy young adults: A resting-state functional magnetic resonance imaging study

“…Because studies have shown that when a longer TR time is used, the physiological parameter signal may alias with the BOLD signal, which will have a certain impact on the analysis of frequency domain indicators, and a shorter TR time is more conducive to rs-fMRI analysis (Raitamaa et al, 2021;Huotari et al, 2022). Moreover, subjects may present different brain BOLD signals between awake and asleep, even in the resting state (Tagliazucchi and Laufs, 2014;Liu and Falahpour, 2020;Helakari et al, 2022). Therefore, state monitoring during rs-fmri scanning is also necessary.…”

Data collection of biomedical data and sensing information in smart rooms

“…Data to be linked to the apps were routed through the mobile device once. The collected data can be used for the analysis of the sleep state and the daily activities [4] , [5] , [6] , for example.

Fig.

…”