Human neutrophil antigen frequency data for Malays, Chinese and Indians

Hajar, Che Ghazali Norul; Zulkafli, Zefarina; Riffin, Nor Suhaila Md.; Mohammad, Tuan Hulwani Tuan; Safuan, Sabreena; Nelson, Bryan Raveen; Abdullah, Mohd Tajuddin; Chambers, Geoffrey K.; Edinur, Hisham Atan

doi:10.1016/j.transci.2019.09.004

Cited by 8 publications

(20 citation statements)

References 7 publications

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“…Similarly, our findings indicated ITGAL∗1 as a common allele. Similar results have been obtained from Malay, Chinese, and Indian populations [ 8 ].…”

Section: Discussionsupporting

confidence: 89%

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Human Neutrophil Antigen Genotype and Allele Frequencies in Iranian Blood Donors

Esmaeili

Bayat

Alirezaee

et al. 2022

Journal of Immunology Research

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Objective. Human neutrophil antigens (HNAs) can be targeted by HNA-allo antibodies and cause a variety of clinical conditions such as transfusion-related acute lung injury (TRALI) and neonatal alloimmune neutropenia (NAIN). The current study is aimed at identifying the genotype and allele frequencies of HNAs in Iranian blood donors. Methods. A total of 150 blood samples were obtained from healthy blood donors. HNA-1, HNA-3, HNA-4, and HNA-5 were genotyped, using the polymerase chain reaction sequence-specific primer (PCR-SSP) technique. The expression of the HNA-2 antigen on the neutrophil surface was evaluated by flow cytometry. Results. The allele frequencies of FCGR3B ∗ 1 (encoding HNA-1a), FCGR3B ∗ 2 (encoding HNA-1b), and FCGR3B ∗ 3 (encoding HNA-1c) were 0.34, 0.63, and 0.03, respectively. For HNA-3, the allele frequencies for SLC44A2 ∗ 1 (encoding HNA-3a) and SLC44A2 ∗ 2 (encoding HNA-3b) were 0.63 and 0.37, respectively. The frequencies of ITGAM ∗ 1 (encoding HNA-4a) and ITGAM ∗ 2 (encoding HNA-4b) alleles were 0.85 and 0.15, respectively. Furthermore, the frequencies of ITGAL ∗ 1 (encoding HNA-5a) and ITGAL ∗ 2 (encoding HNA-5b) alleles were 0.72 and 0.28, respectively. In the studied population, HNA-2 antigen was present on the neutrophil surface in 97.3% of the individuals, while no detectable HNA-2 expression was observed in 2.7% of the individuals. However, no significant difference in HNA-2 expression between different age groups was found. Conclusion. The present study provides the first report of the HNA allele and genotype frequencies among the Iranian population. All HNAs (HNA-1 to HNA-5) were typed using the PCR-SSP and flow cytometer. In the current cohort study, the determined HNA allele frequencies were similar to the previous reports from British, German, and Danish populations. Considering the presence of different Iranian ethnic groups, further studies with a larger sample size are needed to draw a total picture for HNA allele frequencies.

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“…Similarly, our findings indicated ITGAL∗1 as a common allele. Similar results have been obtained from Malay, Chinese, and Indian populations [ 8 ].…”

Section: Discussionsupporting

confidence: 89%

“…HNA allele frequencies have been extensively studied among different populations such as Japanese [ 7 ], Chinese [ 8 ], Hong Kong [ 9 ], Thai [ 10 ], Turkish, German [ 11 ], and Africa American [ 12 ], African Blacks [ 13 ], northern Germany and Uganda [ 14 ], and Danish and Zambian [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Human Neutrophil Antigen Genotype and Allele Frequencies in Iranian Blood Donors

Esmaeili

Bayat

Alirezaee

et al. 2022

Journal of Immunology Research

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“…Peripheral blood sample (50 μl) was extracted for genomic DNA using Invisorb® Spin Forensic Kit (STRATEC Molecular, Berlin, Germany). Extraction protocols were as per manufacturer's recommendations and as described earlier [18]. Genomic DNA concentration and purity for downstream PCR applications were estimated with Nanodrop 2000c spectrophotometer (Thermo Scientific, MA, USA).…”

Section: Molecular Typing Of Other Blood Group Systemsmentioning

confidence: 99%

Extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia

Hajar

Zulkafli

Riffin

et al. 2020

Egypt J Med Hum Genet

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Background Blood group antigens are immunogenic polymorphic molecules presented on the surface of RBCs. This study aimed to determine extended blood group profiles (ABO, Rhesus, Kell, Kidd, Duffy, MNS, Cartwright, Dombrock, Colton, Lutheran, and Vel) in Malays, Chinese, and Indians in Peninsular Malaysia. Results Here, ABO Type O, DCCee, MNs, and Fy (a+b−) were the most frequent major blood group phenotypes in all three ethnic groups. Other minor blood group systems distributed differently across these ethnic groups, except for the Kell, Lutheran, Cartwright, and Vel blood group systems, where only K+k−, Lu (8+14), Yt (a+b−), and Vel (+) phenotypes were observed. Exact tests of population differentiation generally showed no significant differences between Malays included in the present study vs. other ethnically similar datasets from previous surveys. However, many significant differences were recorded in comparison between blood group datasets from ethnically unrelated populations (Malays vs. Chinese vs. Indians) especially for Rhesus, Kidd, and Duffy blood group systems. A Principal component analysis (PCA) plot showed that population groups from the Peninsular Malaysia map closely together as compared with population groups from other geographical regions. Conclusions Overall, our present study has successfully provided an extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia. These new blood group datasets can be used as guidelines for donor recruitment and as reference standards for studying diseases associated with blood group systems.

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“…These earlier studies have provided a valuable preliminary source of genetic information for health assessments and population genetics. However, a complete picture of the genetic structure in Peninsular Malaysia should also include data from Malays (i.e., Deutero-Malays), Chinese, and Indians, as they represent >75% of the total population [ 5 ]. There are some HPA data for Malays, Chinese, and Indians reported by Tan, et al [ 6 ]; the present HPA data can be compared with those data.…”

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confidence: 99%

Human Platelet Antigen Datasets for Malays, Chinese, and Indians in Peninsular Malaysia

et al. 2020

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Human neutrophil antigen frequency data for Malays, Chinese and Indians

Cited by 8 publications

References 7 publications

Human Neutrophil Antigen Genotype and Allele Frequencies in Iranian Blood Donors

Human Neutrophil Antigen Genotype and Allele Frequencies in Iranian Blood Donors

Extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia

Human Platelet Antigen Datasets for Malays, Chinese, and Indians in Peninsular Malaysia

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