Extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia

Hajar, Che Ghazali Norul; Zulkafli, Zefarina; Riffin, Nor Suhaila Md.; Mohammad, Tuan Hulwani Tuan; Hassan, Mohd Nazri; Poonachi, Prathapan; Safuan, Sabreena; ElGhazali, Gehad; Chambers, Geoffrey K.; Edinur, Hisham Atan

doi:10.1186/s43042-020-00096-y

Cited by 8 publications

(6 citation statements)

References 45 publications

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“…The CO*A and CO*B allele frequencies in Thai and other populations are shown in Table 3 . The CO*A and CO*B frequencies among Thais were similar to previously reported in Thai, 16 Taiwanese, 17 Chinese 6 and Malay-Malaysian 7 populations ( p > 0.05). Significant differences were observed when CO*A and CO*B allele frequencies among Thais compared with South Asian, 6 Southeast Asian, 6 Korean, 6 Japanese, 6 Filipino, 6 French Basque, 10 and Maltese 11 populations ( p < 0.01).…”

Section: Resultssupporting

confidence: 87%

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Genotyping Approach to Predict Coa and Cob Antigens in Thai Blood Donor Populations

Nathalang¹,

Asisathaporn²,

Intharanut³

et al. 2023

JBM

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Purpose Co a and Co b antigens of the Colton (CO) blood group system are implicated in acute and delayed hemolytic transfusion reactions (HTRs). Owing to the inadequate supply of specific antiserum, data on CO phenotypes remain limited. This study aimed to develop genotyping methods to predict Co a and Co b antigens and to estimate transfusion-induced alloimmunization risks in three Thai blood donor populations. Materials and Methods The study included 2451 blood samples from unrelated healthy Thai blood donors obtained from central, northern, and southern Thailand. DNA sequencing was used to determine the CO*A and CO*B alleles. In-house PCR with sequence-specific primers (PCR-SSP) and high-resolution melting curve (HRM) assays were performed and genotyping results were compared using DNA sequencing. CO*A and CO*B allele frequencies among Thais were determined using PCR-SSP and their frequencies were compared with other populations. The risks of Co a and Co b transfusion-induced alloimmunization among Thai donor populations were calculated. Results The validated genotyping results by PCR-SSP and HRM assays agreed with DNA sequencing. The CO*A / CO*A was the most common (100.0, 100.0, and 99.3%), followed by CO*A / CO*B (0.0, 0.0, and 0.7%) among central, northern and southern Thais. Homozygous CO*B / CO*B was not found. The CO*A and CO*B allele frequencies among central Thais significantly differed compared among southern Thais ( p < 0.01) but not among northern Thais. Those allele frequencies among Thais were similar to those of Taiwanese, Chinese and Malay-Malaysian populations but not to South Asian, Southeast Asian, Korean, Japanese, Filipino, French Basque, and Maltese populations ( p < 0.01). A higher risk of anti-Co b production rather than anti-Co a production was particularly noted in the southern Thai population. Conclusion This study constitutes the first to determine CO*A and CO*B genotypes using PCR-SSP and HRM assays among Thais and this finding would be beneficial in predicting alloimmunization risk and providing safe transfusions among Thais.

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Section: Resultssupporting

confidence: 87%

“…The two-tailed Fisher’s exact test of homogeneity was used to determine the differences of their allele frequencies among central, northern and southern Thais and to compare the differences with those reported in other populations. 6 , 7 , 10 , 11 , 16 , 17 A p -value of less than 0.05 was considered statistically significant.…”

Section: Methodsmentioning

confidence: 99%

Genotyping Approach to Predict Coa and Cob Antigens in Thai Blood Donor Populations

Nathalang¹,

Asisathaporn²,

Intharanut³

et al. 2023

JBM

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“…The Rh-positive was predominant, and the Rh-negative ranged from 3.2% to 66.7%. The absence of Rh-negative in Indonesian, Malaysian, Thai, and Filipino agree with studies, which reported <1% of Rh-negative [38,44,49,[80][81][82]. The higher negativity in Tunisian, Chinese, and Cameroonian is due to their small number.…”

Section: Discussionsupporting

confidence: 86%

“…The Malaysian (n=7) and Somali (n=18) had the frequency of O>A>AB with an absence of B blood group. In Malaysia, the frequency was either O>B>A>AB or O>A>B>AB [43,44]. In Somalia, the frequency was O>A>B>AB [45].…”

Section: Discussionmentioning

confidence: 99%

Frequency of ABO and Rhesus blood groups in Saudi healthy blood donors versus non-Saudi in a retrospective study in Makkah City

Moustafa

Aldosari

Albukhari

et al. 2021

SMHJ

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Purpose: to assess the frequency of ABO and Rh blood groups among Saudi and non-Saudi healthy blood donors and to compare between them. Methods: A retrospective study was conducted; in Makkah City, Saudi Arabia. It included 15,365 participants of 44 nationalities who have attended the blood bank of King Abdul Aziz Hospital. The collected data were age, sex, nationality, ABO, and Rhesus blood groups. Results: 46.8 % of the participants were O, 28.8 % A, 19.5 % B, and 4.9% AB. The nationalities with a higher frequency of blood group O were Saudi, Mauritanian, Yemeni, Thai, Malian, Sudanese, Jordanian, Indian, Moroccan, Somali, Malaysian, Indonesian, Myanmar, Nigerian, Pakistani, Bangladeshi, Algerian, Djibouti, Burkinabe, Eritrean, Ghanaian, Bahraini, Bosnian, Canadian, Gambian, Iraqi, and Sri Lankan. Those with a higher frequency of blood group A were Turkish, Palestinian, Syrian, Lebanese, Egyptian, Afghan, Chadian, French, Tunisian, Cameroonian, Ethiopian, and British. Those with a higher frequency of B were Nigerien, American, Nepalese, and two nationalities with higher AB frequency Filipino and Chinese. 91.6 % of all populations were Rh-positive, and 8.4% were Rh-negative. The Saudi participants were like some nationalities and differed from others. Conclusion: In Makkah city, the higher frequency of ABO blood group in Saudi and non -Saudi people is O followed by A, then B, and AB. The Rh-positive is predominant, and 8.4% of the participants are negative. The ABO and Rh blood groups' identifications are essential for providing suitable blood storage for individuals in need.

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“…This observation was taken to indicate that the admixture fraction in the contemporary population was around 0.50. Hajar et al (2020) have recently examined the interface between population genetics and human health as it relates to Austronesian populations. For example, they point to the significance of blood group loci as important markers of transfusion success including Kidd Jk (a-b+) and Duffy Fy (a+b+) which are relatively common in this ethnic group but less common in others.…”

Section: Some Illustrative Examplesmentioning

confidence: 99%

Ethnicity-based classifications and medical genetics: One Health approaches from a Western Pacific perspective

2022

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A new era presently dawns for medical genetics featuring individualised whole genome sequencing and promising personalised medical genetics. Accordingly, we direct readers attention to the continuing value of allele frequency data from Genome-Wide Association Surveys (GWAS) and single gene surveys in well-defined ethnic populations as a guide for best practice in diagnosis, therapy, and prescription. Supporting evidence is drawn from our experiences working with Austronesian volunteer subjects across the Western Pacific. In general, these studies show that their gene pool has been shaped by natural selection and become highly diverged from those of Europeans and Asians. These uniquely evolved patterns of genetic variation underlie contrasting schedules of disease incidence and drug response. Thus, recognition of historical bonds of kinship among Austronesian population groups across the Asia Pacific has distinct public health advantages from a One Health perspective. Other than diseases that are common among them like gout and diabetes, Austronesian populations face a wide range of climate-dependent infectious diseases including vector-borne pathogens as they are now scattered across the Pacific and Indian Oceans. However, we caution that the value of genetic survey data in Austronesians (and other groups too) is critically dependent on the accuracy of attached descriptive information in associated metadata, including ethnicity and admixture.

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Extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia

Cited by 8 publications

References 45 publications

Genotyping Approach to Predict Coa and Cob Antigens in Thai Blood Donor Populations

Genotyping Approach to Predict Coa and Cob Antigens in Thai Blood Donor Populations

Frequency of ABO and Rhesus blood groups in Saudi healthy blood donors versus non-Saudi in a retrospective study in Makkah City

Ethnicity-based classifications and medical genetics: One Health approaches from a Western Pacific perspective

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