Human monkeypox preparedness in Latin America – Are we ready for the next viral zoonotic disease outbreak after COVID-19?

Cimerman, Sérgio; Chebabo, Alberto; Cunha, Clóvis Arns da; Barbosa, Alexandre Naime; Rodríguez-Morales, Alfonso J.

doi:10.1016/j.bjid.2022.102372

Cited by 20 publications

(14 citation statements)

References 6 publications

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“…Even more, assessing the impact of spreading events, including the pride parties and festivals on Grand Canary island in Spain or Belgium, needs better evaluations [ 18 , 36 , 41 , 42 , 71 – 73 ]. More studies are also required from non-European and non-African countries, including North and Latin America, the Middle East and Oceania, regions already affected by monkeypox [ 8 , 42 , 49 ]. Further clinical data is crucial to elucidate the clinical spectrum of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Over the last months, more than 18,000 cases of monkeypox have been reported outside Africa, in more than 70 countries (up to July 27, 2022), for the first time in more than five decades since the virus was first detected in humans [47][48][49][50]. Monkeypox is an emerging condition outside endemic countries, rapidly spreading to multiple countries and continents due to different factors, including its potential sexual transmission [51,52].…”

Section: Discussionmentioning

confidence: 99%

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Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis

Benítes-Zapata

Ulloque-Badaracco

Alarcón-Braga

et al. 2022

Ann Clin Microbiol Antimicrob

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Introduction A multicountry monkeypox disease (MPX) outbreak began in May 2022 in Europe, leading to the assessment as a potential Public Health Emergency of International Concern (PHEIC) on June 23, 2022. Some observational studies have partially characterised clinical features, hospitalisations, and deaths. However, no systematic reviews of this MPX outbreak have been published. Methods We performed a systematic review with meta-analysis, using five databases to assess clinical features, hospitalisations, complications and deaths of MPX confirmed or probable cases. Observational studies, case reports and case series, were included. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95% CI). In addition, we carried out a subgroup analysis according to the continents and a sensitivity analysis excluding studies classified as having a high risk of bias. Results A total of 19 articles were included, using only 12 articles in the quantitative synthesis (meta-analysis). For 1958 patients, rash (93%, 95% CI 80–100%), fever (72%, 95% CI 30–99%), pruritus (65%, 95% CI 47–81%), and lymphadenopathy (62%, 47–76%), were the most prevalent manifestations. Among the patients, 35% (95% CI 14–59%) were hospitalised. Some 4% (95% CI 1–9%) of hospitalised patients had fatal outcomes (case fatality rate, CFR). Conclusion MPX is spreading rapidly, with a third of hospitalised patients, but less than 5% with fatal outcomes. As this zoonotic virus spreads globally, countries must urgently prepare human resources, infrastructure and facilities to treat patients according to the emerging guidelines and the most reliable clinical information.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis

Benítes-Zapata

Ulloque-Badaracco

Alarcón-Braga

et al. 2022

Ann Clin Microbiol Antimicrob

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“…Latin America, fortunately, is now more prepared to confront new epidemic threats, as in the case of MPX. 10 …”

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confidence: 99%

Latin America: Situation and preparedness facing the multi-country human monkeypox outbreak

Rodríguez-Morales

Lopardo

Verbanaz

et al. 2022

The Lancet Regional Health - Americas

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“…Furthermore, there are confirmed cases in Mexico and Argentina, and suspected cases in Ecuador and Bolivia, estimated at 506 cases, 421 of whom were confirmed cases (83%). Monkeypox cases have also been reported from Latin America (4,5).…”

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confidence: 99%

Rising Concern of Monkeypox as a Viral Zoonosis After COVID-19 Era

Mardani

Pourkaveh

2022

Arch Clin Infect Dis

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Human monkeypox preparedness in Latin America – Are we ready for the next viral zoonotic disease outbreak after COVID-19?

Cited by 20 publications

References 6 publications

Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis

Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis

Latin America: Situation and preparedness facing the multi-country human monkeypox outbreak

Rising Concern of Monkeypox as a Viral Zoonosis After COVID-19 Era

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