Human Milk Mucin 1 and Mucin 4 Inhibit Salmonella enterica Serovar Typhimurium Invasion of Human Intestinal Epithelial Cells In Vitro

Liu, Bo; Yu, Zhuoteng; Chen, Ceng; Kling, David E.; Newburg, David S.

doi:10.3945/jn.111.155614

Cited by 61 publications

(43 citation statements)

References 35 publications

(35 reference statements)

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“…Sialic-acid glycans from MUC1 prevented attachment of S-fimbriated E. coli to buccal mucosal cells (184). Milk concentrations of MUC1 and MUC4 prevented invasion of Caco-2 by S. typhimurium , although the role of glycans in this phenomenon was not addressed (185). …”

Section: Milk Glycobiome Mediates Protection Against Infectious Diseasesmentioning

confidence: 99%

The Impact of the Milk Glycobiome on the Neonate Gut Microbiota

Pacheco¹,

Barile

Underwood³

et al. 2015

Annu. Rev. Anim. Biosci.

152

142

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Human milk is a complete source of nourishment for the infant. Exclusive breastfeeding not only sustains the infant’s development but also guides the proliferation of a protective intestinal microbiota. Among the many components of milk that modulate the infant gut microbiota, the milk glycans, which comprise free oligosaccharides, glycoproteins, and glycolipids, are increasingly recognized as drivers of microbiota development and overall gut health. These glycans may display pleiotropic functions, conferring protection against infectious diseases and also acting as prebiotics, selecting for the growth of beneficial intestinal bacteria. The prebiotic effect of milk glycans has direct application to prevention of diseases such as necrotizing enterocolitis, a common and devastating disease of preterm infants. In this article, we review the impact of the human (and bovine) milk glycome on gut health through establishment of a milk-oriented microbiota in the neonate.

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Section: Milk Glycobiome Mediates Protection Against Infectious Diseasesmentioning

confidence: 99%

The Impact of the Milk Glycobiome on the Neonate Gut Microbiota

Pacheco¹,

Barile

Underwood³

et al. 2015

Annu. Rev. Anim. Biosci.

152

142

View full text Add to dashboard Cite

show abstract

“…There are two types of mucins that has been the focus of research, MUC1 and MUC4 [32••]. A recent study showed that these mucins could inhibit Salmonella enterica serovar Typhimurium invasion of human epithelial cells in vitro [50]. Sialylated human milk mucin inhibited rotavirus replication in tissue culture and prevented rotavirus gastroenteritis in a mouse model; and blocked the adhesion of recombinant norovirus-like particles [32••].…”

Section: Protective Components Of Human Milkmentioning

confidence: 99%

The Role of Maternal Breast Milk in Preventing Infantile Diarrhea in the Developing World

Turin

Ochoa

2014

Curr Trop Med Rep

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Multiple interventions have been designed to decrease mortality and disability in children. Among these, breastfeeding is the most cost effective intervention for protecting children against diarrhea and all causes of mortality. Human milk is uniquely suited to the human infant, both in its nutritional composition and in the nonnutritive bioactive factors that promote survival and healthy development. Suboptimal breastfeeding has been linked with numerous adverse child health outcomes including increased incidence of diarrhea and pneumonia. This review provides an update regarding recent studies on the effect of breastfeeding on diarrhea morbidity and mortality in children in developing countries, describes major human milk components responsible for this protective effect (oligosaccharides, secretory immunoglobulins, lactoferrin, bacterial microbiota, etc.), and highlights areas for future research in this topic. Breastfeeding promotion remains an intervention of enormous public health potential to decrease global mortality and promote better growth and neurodevelopment in children.

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“…Moreover, soluble factors contained in maternal milk also contribute to the protection of the neonates during breast feeding time and will be discussed later on. Of note, human milk contains mucin 1 and 4 which can bind pathogenic bacteria such as Salmonella Typhimurium and by competition with the host immune receptors, inhibit the invasion of epithelial cells [86]. Also, human milk oligosaccharides favor the selection of specific bacteria such as Bifidobacterium infantis which are able to consume them via mucus-utilization pathways, facilitating milk and solid food digestion [87].…”

Section: Adaptation Of the Gut Mucosa To Bacterial Colonizationmentioning

confidence: 99%

Neonatal Immune Adaptation of the Gut and Its Role during Infections

Tourneur

Chassin

2013

Clinical and Developmental Immunology

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The intestinal tract is engaged in a relationship with a dense and complex microbial ecosystem, the microbiota. The establishment of this symbiosis is essential for host physiology, metabolism, and immune homeostasis. Because newborns are essentially sterile, the first exposure to microorganisms and environmental endotoxins during the neonatal period is followed by a crucial sequence of active events leading to immune tolerance and homeostasis. Contact with potent immunostimulatory molecules starts immediately at birth, and the discrimination between commensal bacteria and invading pathogens is essential to avoid an inappropriate immune stimulation and/or host infection. The dysregulation of these tight interactions between host and microbiota can be responsible for important health disorders, including inflammation and sepsis. This review summarizes the molecular events leading to the establishment of postnatal immune tolerance and how pathogens can avoid host immunity and induce neonatal infections and sepsis.

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Human Milk Mucin 1 and Mucin 4 Inhibit Salmonella enterica Serovar Typhimurium Invasion of Human Intestinal Epithelial Cells In Vitro

Cited by 61 publications

References 35 publications

The Impact of the Milk Glycobiome on the Neonate Gut Microbiota

The Impact of the Milk Glycobiome on the Neonate Gut Microbiota

The Role of Maternal Breast Milk in Preventing Infantile Diarrhea in the Developing World

Neonatal Immune Adaptation of the Gut and Its Role during Infections

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