Human milk contamination by nine organochlorine pesticide residues (OCPs)

Souza, Raiane Costa; Portella, Roberto Bagattini; Almeida, Paula Valéria Nunes Brito; Pinto, Caroline Oliveira; Gubert, Priscila; Silva, José Domingos Santos da; Nakamura, Thamilin Costa; Rego, Enoc Lima do

doi:10.1080/03601234.2020.1729630

Cited by 31 publications

(12 citation statements)

References 38 publications

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“…The EDI was estimated using the following equation: EDI = Cmilk × Cfat × Mingestion/BW; where EDI = estimated daily intake; Cmilk = pesticide concentration of pesticide in milk (ng/g of lipid); Cfat = milk fat content (%) in breastmilk; Mingestion = intake of breast milk [21]. The adopted values for EDI estimation were: 4% of lipid [22] and 700 g of human milk/day [23]. The HQ was calculated as the EDI divided by the reference dose (RfD) proposed by EPA (5 µg of ΣDDT/kg body wt./day) [24] and the provisional tolerable weekly intake (PTWI) adopted by FAO/WHO (10 µg of ΣDDT/kg body wt./day) [25][26][27].…”

Section: Estimated Daily Intake and Hazard Quotient Calculations For ...mentioning

confidence: 99%

“…The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ijerph20010778/s1, Table S1: Calibration parameters and limits for OCs and PCBs; Table S2: Estimated HQ from breast milk described in the literature. References [21][22][23][54][55][56][57][58] are cited in the supplementary materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

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Persistent Organic Pollutant Levels in Maternal and Cord Blood Plasma and Breast Milk: Results from the Rio Birth Cohort Pilot Study of Environmental Exposure and Childhood Development (PIPA Study)

Santos

Moreira

Rosa

et al. 2022

IJERPH

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Levels of polychlorinated biphenyls (PCB) and organochlorine pesticides (OCP) were evaluated in the breast milk and maternal and umbilical cord blood of pregnant women and their newborns in Rio de Janeiro, Brazil. The concentration of 11 PCB and 17 OCP were measured in 135 samples of maternal, and 116 samples of cord blood plasma, as well as 40, 47, and 45 samples of breast milk at 1st, 3rd, and 6th months after birth, respectively, using gas chromatography-mass spectrometry (GC-MS-MS). Women were asked to answer an enrollment questionnaire with reproductive, lifestyle, residential and sociodemographic questions. The most commonly detected OCPs and PCBs in the maternal and cord blood were 4,4′-DDE; β-HCH; ɣ-HCH; and PCB 28. 4,4′-DDE was also the most commonly detected OCP in breast milk samples. Although not statistically significant, ∑DDT levels were higher among women with pregestational BMI ≥ 30, and who were non-white and older (age > 40). Newborns with an Apgar score ≤ 8 at minute 5 of life showed significantly higher levels of ∑DDT in the cord blood. Persistent OCPs and PCBs were still detected in maternal and umbilical cord blood and breast milk, even after decades of their banishment in Brazil. They may pose a risk to maternal, fetal and children’s health.

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Section: Estimated Daily Intake and Hazard Quotient Calculations For ...mentioning

confidence: 99%

Section: Supplementary Materialsmentioning

confidence: 99%

Persistent Organic Pollutant Levels in Maternal and Cord Blood Plasma and Breast Milk: Results from the Rio Birth Cohort Pilot Study of Environmental Exposure and Childhood Development (PIPA Study)

Santos

Moreira

Rosa

et al. 2022

IJERPH

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“…Those components can disrupt the endocrine system by causing hormonal imbalances [109]. Moreover, organochlorine accumulation was linked to a higher risk of several types of genotoxicity, human cancer, and mental and psychomotor development [110]. Nanomaterials have been shown in toxicological studies to be neurotoxic, cytotoxic, genotoxic, bactericidal, and ecotoxic.…”

Section: Pesticidesmentioning

confidence: 99%

A Review on Emerging Pollutants in the Water Environment: Existences, Health Effects and Treatment Processes

Arman

Salmiati

Aris

et al. 2021

Water

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Emerging pollutants (EPs), also known as micropollutants, have been a major issue for the global population in recent years as a result of the potential threats they bring to the environment and human health. Pharmaceuticals and personal care products (PPCPs), antibiotics, and hormones that are used in great demand for health and cosmetic purposes have rapidly culminated in the emergence of environmental pollutants. EPs impact the environment in a variety of ways. EPs originate from animal or human sources, either directly discharged into waterbodies or slowly leached via soils. As a result, water quality will deteriorate, drinking water sources will be contaminated, and health issues will arise. Since drinking water treatment plants rely on water resources, the prevalence of this contamination in aquatic environments, particularly surface water, is a severe problem. The review looks into several related issues on EPs in water environment, including methods in removing EPs. Despite its benefits and downsides, the EPs treatment processes comprise several approaches such as physico-chemical, biological, and advanced oxidation processes. Nonetheless, one of the membrane-based filtration methods, ultrafiltration, is considered as one of the technologies that promises the best micropollutant removal in water. With interesting properties including a moderate operating manner and great selectivity, this treatment approach is more popular than conventional ones. This study presents a comprehensive summary of EP’s existence in the environment, its toxicological consequences on health, and potential removal and treatment strategies.

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“…Other biological fluids analyzed included serum, blood, and plasma. In addition, some studies were focused on assessing pesticide exposure to pregnant and lactating women and its correlation with possible prenatal exposure to the fetus or to the newborn through breastfeeding [ 83 , 84 , 85 , 86 ]. For this purpose, breast milk, cord blood, and placenta samples were analyzed.…”

Section: Direct Approachesmentioning

confidence: 99%

Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

2021

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Background: Pesticide residues are a threat to the health of the global population, not only to farmers, applicators, and other pesticide professionals. Humans are exposed through various routes such as food, skin, and inhalation. This study summarizes the different methods to assess and/or estimate human exposure to pesticide residues of the global population. Methods: A systematic search was carried out on Scopus and web of science databases of studies on human exposure to pesticide residues since 2019. Results: The methods to estimate human health risk can be categorized as direct (determining the exposure through specific biomarkers in human matrices) or indirect (determining the levels in the environment and food and estimating the occurrence). The role that analytical techniques play was analyzed. In both cases, the application of generic solvent extraction and solid-phase extraction (SPE) clean-up, followed by liquid or gas chromatography coupled to mass spectrometry, is decisive. Advances within the analytical techniques have played an unquestionable role. Conclusions: All these studies have contributed to an important advance in the knowledge of analytical techniques for the detection of pesticide levels and the subsequent assessment of nonoccupational human exposure.

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Human milk contamination by nine organochlorine pesticide residues (OCPs)

Cited by 31 publications

References 38 publications

Persistent Organic Pollutant Levels in Maternal and Cord Blood Plasma and Breast Milk: Results from the Rio Birth Cohort Pilot Study of Environmental Exposure and Childhood Development (PIPA Study)

Persistent Organic Pollutant Levels in Maternal and Cord Blood Plasma and Breast Milk: Results from the Rio Birth Cohort Pilot Study of Environmental Exposure and Childhood Development (PIPA Study)

A Review on Emerging Pollutants in the Water Environment: Existences, Health Effects and Treatment Processes

Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

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