Human Milk and Allergic Diseases: An Unsolved Puzzle

Munblit, Daniel; Peroni, Diego; Boix-Amorós, Alba; Hsu, Peter; Land, Belinda van‘t; Gay, Melvin; Kolotilina, Anastasia; Skevaki, Chrysanthi; Boyle, Robert; Collado, María Carmen; Garssen, Johan; Geddes, Donna; Nanan, Ralph; Slupsky, Carolyn M.; Wegienka, Ganesa; Kozyrskyj, Anita L.; Warner, John O.

doi:10.3390/nu9080894

Cited by 104 publications

(135 citation statements)

References 359 publications

(414 reference statements)

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“…10,[28][29][30] In addition to m-sCD14, several other breast milk components have been implicated as possible targets for further research including transforming growth factor (TGF)-β, 23,31 interleukin (IL)-10, 31 erythropoietin, lactoferrin, certain fatty acids and inflammation-related hormones such as leptin. 33 Therefore, gene loci associated with atopy or specifically atopic dermatitis may also serve as additional targets for study. 33 Therefore, gene loci associated with atopy or specifically atopic dermatitis may also serve as additional targets for study.…”

Section: Discussionmentioning

confidence: 99%

Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: Results of the Ulm Birth Cohort Studies

Logan

Weiss²,

Köenig

et al. 2018

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: Results of the Ulm Birth Cohort Studies

Logan

Weiss²,

Köenig

et al. 2018

Clin Experimental Allergy

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“…Also, the supplementation of the maternal diet with probiotics ( Lactobacillus rhamnosus and Bifidobacterium animalis ) was shown to reduce the risk of eczema in breastfed infants (Rautava, Kainonen, Salminen, & Isolauri, ). These results suggest that modulating the maternal diet might have therapeutic potential for breast milk to offer secondary prevention towards allergic disorders during childhood (Daniel Munblit et al., ). Current guidelines orient practitioners and pregnant women to maintain a healthy intake of micro‐ and macronutrients in order to protect mother and developing fetus (Kominiarek & Rajan, ).…”

Section: Pre‐ and Postnatal Events Involved In Intestinal Barrier Matmentioning

confidence: 99%

Relationship Between Oligosaccharides and Glycoconjugates Content in Human Milk and the Development of the Gut Barrier

Figueroa-Lozano

Vos

2018

Comp Rev Food Sci Food Safe

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The intestinal immune barrier is considered to be the gatekeeper of the human body and rapidly develops directly after birth. Many pre‐ and postnatal factors influence the development of the gut‐barrier, which is composed of the microbiota, the mucus, the epithelial layer and the mucosal immune system. Even minor disturbances during barrier development can have consequences for health far into adulthood. Here we critically discuss the current knowledge on which pre‐ and postnatal factors influence development, maturation, and maintenance of the gut immune barrier. Human milk has a unique composition and is the gold standard for adequate development of the intestinal immune barrier. Not only the influence of human milk oligosaccharides (HMOs) but also that of glycoproteins (HMGPs) is reviewed. We discuss the influence of maternal genetic factors, such as the secretor and Lewis phenotypes on breast milk fucosylation and sialylation of HMOs and HMGPs. This diversity in HMOs and HMPGs influences microbiota composition and also the development of the immune barrier. Cow milk‐derived infant formula is often being used as an alternative for human breast milk. The consequences of this for proper development of the intestinal immune barrier and, in particular, the differences in the type of oligosaccharides and glycosylation patterns (sialic and fucose composition) between cow and human milk are critically discussed. Current and prospective strategies to promote proper gut‐immune maturation are proposed. These might include more personalized infant formulas when breast milk is not an option.

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“…Inflammation may be viewed as a byproduct of the metabolic activity of gut microbiota from evidence that SCFAs are altered in overweight or atopic children [38]. …”

Section: Fats In Infant Formulae Intended For Medical Condition (Amentioning

confidence: 99%

The Role of Lipids in Human Milk and Infant Formulae

et al. 2018

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The quantity and quality of dietary lipids in infant formulae have a significant impact on health outcomes, especially when fat storing and/or absorption are limited (e.g., preterm birth and short bowel disease) or when fat byproducts may help to prevent some pathologies (e.g., atopy). The lipid composition of infant formulae varies according to the different fat sources used, and the potential biological effects are related to the variety of saturated and unsaturated fatty acids. For example, since lipids are the main source of energy when the normal absorptive capacity of the digestive tract is compromised, medium-chain saturated fatty acids might cover this requirement. Instead, ruminant-derived trans fatty acids and metabolites of n-3 long-chain polyunsaturated fatty acids with their anti-inflammatory properties can modulate immune function. Furthermore, dietary fats may influence the nutrient profile of formulae, improving the acceptance of these products and the compliance with dietary schedules.

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Human Milk and Allergic Diseases: An Unsolved Puzzle

Cited by 104 publications

References 359 publications

Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: Results of the Ulm Birth Cohort Studies

Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: Results of the Ulm Birth Cohort Studies

Relationship Between Oligosaccharides and Glycoconjugates Content in Human Milk and the Development of the Gut Barrier

The Role of Lipids in Human Milk and Infant Formulae

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