Human Metapneumovirus RNA in Encephalitis Patient

Schildgen, Oliver; Glatzel, Thomas; Geikowski, Tilman; Scheibner, Bärbel; Matz, Bertfried; Bindl, Lutz; Born, M.; Viazov, Sergei; Wilkesmann, Anja; Knöpfle, G; Roggendorf, Michael; Simon, Arne

doi:10.3201/eid1103.040676

Cited by 86 publications

(77 citation statements)

References 13 publications

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“…A case report from Germany in 2005 described a 14-mo-old boy who died of encephalitis, and from whom hMPV was identified in brain tissue by PCR and cell culture (37). Subsequent reports by various groups have described patients with encephalitis from whom hMPV was identified in throat or nasal swabs, although infection of the CNS was not established in these cases (38 -40).…”

Section: Human Metapneumovirusmentioning

confidence: 99%

Human Metapneumovirus and Human Bocavirus in Children

Milder

Arnold

2009

Pediatr Res

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Several new viruses have recently been described in children, including human metapneumovirus (hMPV) and human bocavirus (HBoV). hMPV has been established as a common cause of upper and lower respiratory tract infections in children, often second only to respiratory syncytial virus as a cause of bronchiolitis in infants. Diagnostic tools have been developed for the clinician and effective treatment and prevention strategies are being investigated. HBoV was more recently identified. Although it was initially identified in the airway of children, high rates of codetection of other viral pathogens and detection of the virus in the stool have raised questions about the true role of HBoV as a cause of respiratory infections. A focus on epidemiology, pathogenesis, clinical features, and diagnostic techniques for hMPV and HBoV is presented.

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Section: Human Metapneumovirusmentioning

confidence: 99%

Human Metapneumovirus and Human Bocavirus in Children

Milder

Arnold

2009

Pediatr Res

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“…Several studies demonstrated that HMPV accounts for a major proportion of hospitalizations for lower respiratory tract infections in infants and young children 30,47,50 . The most frequent diagnoses in hospitalized children are bronchiolitis and pneumonia, but occasionally HMPV may also cause severe illnesses that require treatment at intensive care units 41 .…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of the green marine alga Ulva fasciata on the replication of human metapneumovirus

Mendes

Soares

Martins

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYWe evaluated the antiviral activity of the marine alga, Ulva fasciata, collected from Rasa beach and Forno beach, Búzios, Rio de Janeiro, Brazil on the replication of human metapneumovirus (HMPV). The algae extracts were prepared using three different methodologies to compare the activity of different groups of chemical composites obtained through these different methodologies. Four out of the six extracts inhibited nearly 100% of viral replication. The results demonstrated that the majority of the extracts (five out of six) possess virucidal activity and therefore have the ability to interact with the extracellular viral particles and prevent the infection. On the other hand, only two extracts (from Forno beach, obtained by maceration and maceration of the decoction) were able to interact with cell receptors, hindering the viral entry. Finally, only the extract of algae collected at Forno beach, obtained by maceration presented intracellular activity. To our knowledge, this is a pioneer study on antiviral activity of marine algae against HMPV. It is also the first on antiviral activity against HMPV ever done in Brazil. The study also shows the effect of different environment factors and different chemical procedures used to obtain the extract on its biological properties.

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“…The most frequent diagnoses in hospitalized children are bronchiolitis and pneumonia, but occasionally hMPV may also cause severe illnesses that require treatment at intensive care units (17,18).…”

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confidence: 99%

Human Metapneumovirus Infections in Children

Heikkinen

Österback

Peltola

et al. 2008

Emerg. Infect. Dis.

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Human metapneumovirus (hMPV) is an important cause of lower respiratory tract infections in hospitalized children, but the age-related incidence and effect of hMPV in unselected children in the community have not been evaluated. We studied a cohort of 1,338 children <13 years of age throughout 1 respiratory season in Finland during [2000][2001]. We examined children and obtained a nasal swab for viral detection at any sign of respiratory infection. hMPV was detected in 47 (3.5%) of the 1,338 children. The age-related incidence of hMPV infection was highest (7.6%) in children <2 years of age, in whom hMPV accounted for 1.7% of all infections during the season. During the epidemic peak, hMPV caused 7.1% of all respiratory infections in the cohort. Acute otitis media developed in 61% of hMPVinfected children <3 years of age. Our fi ndings demonstrate that the effect of hMPV in the community is greatest in children <2 years of age.

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Human Metapneumovirus RNA in Encephalitis Patient

Cited by 86 publications

References 13 publications

Human Metapneumovirus and Human Bocavirus in Children

Human Metapneumovirus and Human Bocavirus in Children

Antiviral activity of the green marine alga Ulva fasciata on the replication of human metapneumovirus

Human Metapneumovirus Infections in Children

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