Human Metapneumovirus and Human Bocavirus in Children

Abstract

Several new viruses have recently been described in children, including human metapneumovirus (hMPV) and human bocavirus (HBoV). hMPV has been established as a common cause of upper and lower respiratory tract infections in children, often second only to respiratory syncytial virus as a cause of bronchiolitis in infants. Diagnostic tools have been developed for the clinician and effective treatment and prevention strategies are being investigated. HBoV was more recently identified. Although it was initially identified in the airway of children, high rates of codetection of other viral pathogens and detection of the virus in the stool have raised questions about the true role of HBoV as a cause of respiratory infections. A focus on epidemiology, pathogenesis, clinical features, and diagnostic techniques for hMPV and HBoV is presented.

Review of Non-bacterial Infections in Respiratory Medicine: Viral Pneumonia

“…[19][20][21][22] However, because it is so frequently detected in asymptomatic individuals (15%), the etiological role of rhinovirus continues to be questioned, although it could be an indication of real, subclinical infections. 23 Recently identified pathogens, such as metapneumovirus and human bocavirus, [24][25][26][27] are less commonly encountered. Although the prevalence of viral pneumonia caused by adenovirus is low (2%-12%), it must be identified, as it can lead to necrotizing pneumonia.…”

Molecular Detection of Human Metapneumovirus and Human Bocavirus on Oropharyngeal Swabs Collected from Young Children with Acute Respiratory Tract Infections from Rural and Peri-Urban Communities in South India

“…The age and domiciliary status (peri-urban or rural) of each patient was recorded in order to assess the distribution of these viruses in different age groups and different domiciles. Previous studies in different countries have focused on the involvement of both hMPV and HBoV in respiratory tract infections in children [12][13][14][15] and in immunocompromised adults [16].…”

Revisión sobre las infecciones no bacterianas del aparato respiratorio: neumonías víricas

“…No obstante, su papel etiológico no deja de estar cuestionado por su frecuente detección en individuos asintomáticos (15%), si bien pudiera tratarse de verdaderas infecciones subclínicas 23 . Con menos frecuencia se encuentran patógenos identificados en los últimos años, como el metapneumovirus y los bocavirus humanos [24][25][26][27] . Aunque la prevalencia de neumonía viral por adenovirus es baja (2-12%), es importante reconocerla porque puede desembocar en ocasiones en una neumonía necrotizante 28 .…”