Human Metapneumovirus, Peru

Gray, Gregory C.; Capuano, Ana W.; Setterquist, Sharon F.; Sánchez, José L.; Neville, James S.; Olson, James G.; Lebeck, Mark G.; McCarthy, Troy; Abed, Yacine; Boivin, Guy

doi:10.3201/eid1202.051133

Cited by 51 publications

(26 citation statements)

References 14 publications

(11 reference statements)

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“…In this study, hMPV seasonal distribution was characterized by peaks within the winter period, similar to those previously observed elsewhere (Mullins et al 2004, van den Hoogen et al 2004, Gray et al 2006. In another Brazilian study, do Carmo Debur et al (2007) observed that hMPV circulated during winter and spring (do Carmo Debur et al 2007).…”

Section: Discussionsupporting

confidence: 73%

Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil

Pilger¹,

Cantarelli

Amantéa

et al. 2011

Mem. Inst. Oswaldo Cruz

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The introduction of newer molecular methods has led to the discovery of new respiratory viruses, such as human metapneumovirus (hMPV) and human bocavirus (hBoV), in respiratory tract specimens. We have studied the occurrence of hMPV and hBoV in the Porto Alegre (PA) metropolitan area, one of the southernmost cities of Brazil, evaluating children with suspected lower respiratory tract infection from May 2007-June 2008. A real-time polymerase chain reaction method was used for amplification and detection of hMPV and hBoV and to evaluate coinfections with respiratory syncytial virus (RSV), influenza A and B, parainfluenza 1, 2 and 3, human rhinovirus and human adenovirus. Of the 455 nasopharyngeal aspirates tested, hMPV was detected in 14.5% of samples and hBoV in 13.2%. A unique causative viral agent was identified in 46.2% samples and the coinfection rate was 43.7%. For hBoV, 98.3% of all positive samples were from patients with mixed infections. Similarly, 84.8% of all hMPV-positive results were also observed in mixed infections. Both hBoV and hMPV usually appeared with RSV. In summary, this is the first confirmation that hMPV and hBoV circulate in PA; this provides evidence of frequent involvement of both viruses in children with clinical signs of acute viral respiratory tract infection, although they mainly appeared as coinfection agents

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Section: Discussionsupporting

confidence: 73%

Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil

Pilger¹,

Cantarelli

Amantéa

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…Viral specimens were evaluated for molecular evidence of hMPV as per our previous report (Gray et al, 2006). Briefly, specimens were screened with a one-step RT-PCR procedure using primer set F2 (Table 1).…”

Section: Reverse-transcription Polymerase Chain Reaction (Rt-pcr)mentioning

confidence: 99%

Multi-year study of human metapneumovirus infection at a large US Midwestern Medical Referral Center

Gray

Capuano

Setterquist

et al. 2006

Journal of Clinical Virology

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Background-Because of its recent identification, few multi-year epidemiologic studies of hMPV infection have been reported.Objective-We sought to retrospectively describe hMPV infections among patients evaluated by a large US Midwestern referral laboratory. Results-34 (2.6%) of 1294 specimens were hMPV positive. Among these, 21 (62%) were culture positive and available for genetic typing. A previously considered rare genotype of hMPV, B1, was the most common single genotype identified, comprising 9 (43%) of the 21 isolates. Multivariate logistic regression modeling identified patients aged 0.4-9 years (OR = 8.9; 95% CI = 2.0-38.5) and those under intensive care (OR = 3.2; 95% CI = 1.1-8.7) as more likely to have hMPV infection than their peers.Conclusion-In this large referral hospital viral assays more often had evidence of hMPV when they were collected from children receiving intensive care.

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“…Metapneumovirus es un agente de infección respiratoria en circulación desde hace 50 [26][27][28] . Se describen brotes por este agente a fines del invierno y comienzos de la primavera, los que se prolongan hasta después de finalizar el brote de VRS 29 .…”

Section: Discussionunclassified

Apnea como forma de presentación de una infección por metapneumovirus humano

et al. 2007

Rev. chil. infectol.

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Apnea as a presenting symptom in human metapneumovirus infectionHuman metapneumovirus (hMPV), a recently described pathogen of lower respiratory tract infections (LRTI), has been detected in 5,4% of Chilean infants hospitalized for LRTI whom are negative for adenovirus, respiratory syncytial virus, influenza and parainfluenza viruses. hMPV may cause bronchiolitis or pneumonia in hospitalized patients, and ocassionally require admission to intensive care units and mechanical ventilation. The infection has been associated with apnea, especially in preterm infants. Nosocomial dissemination has also been described. We present the case of a one-month-of age premature infant with apnea, and infection caused by hMPV of probable nosocomial aquisition. Clinical features of hMPV infection are reviewed and its association with apnea and nosocomial transmission is discussed. hMPV should be included in the routine diagnosis of respiratory viruses in infants with apnea and should be considered among the respiratory pathogens associated with nosocomial transmission.

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Human Metapneumovirus, Peru

Cited by 51 publications

References 14 publications

Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil

Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil

Multi-year study of human metapneumovirus infection at a large US Midwestern Medical Referral Center

Apnea como forma de presentación de una infección por metapneumovirus humano

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