Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation

Comoli, Patrizia; Ginevri, Fabrizio; Maccario, Rita; Avanzini, Maria Antonietta; Marconi, Massimo; Groff, Antonella; Cometa, Angela; Cioni, Michela; Porretti, Laura; Barberi, Walter; Frassoni, Francesco; Locatelli, Franco

doi:10.1093/ndt/gfm740

Cited by 131 publications

(113 citation statements)

References 25 publications

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“…Moreover, thirdparty BMSCs transplantation could prolong skin graft survival time by inhibiting T lymphocyte activation and proliferation [43] . Third-party MSCs were able to suppress allo-specific antibody production in vitro, and they might rescue patients with life-threatening GVHD in vivo [44] . Likewise, the donor haematopoietic stem cells had the capacity to reduce the risk of GVHD [45] .…”

Section: Necrosismentioning

confidence: 99%

New advances in the mesenchymal stem cells therapy against skin flaps necrosis

Zhang¹

2014

WJSC

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Mesenchymal stem cells (MSCs), multipotential cells that reside within the bone marrow, can be induced to differentiate into various cells, such as osteoblasts, adipocytes, chondrocytes, vascular endothelial progenitor cells, and other cell types. MSCs are being widely studied as potential cell therapy agents due to their angiogenic properties, which have been well established by in vitro and in vivo researches. Within this context, MSCs therapy appears to hold substantial promise, particularly in the treatment of conditions involving skin grafts, pedicle flaps, as well as free flaps described in literatures. The purpose of this review is to report the new advances and mechanisms underlying MSCs therapy against skin flaps necrosis.

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Section: Necrosismentioning

confidence: 99%

New advances in the mesenchymal stem cells therapy against skin flaps necrosis

Zhang¹

2014

WJSC

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“…Furthermore, not only MSCs affect dendritic cell recruitment, maturation, and function but also significantly reduce monocyte differentiation into the dendritic cell type [149][150][151][152][153]. Last but not least, MSCs alter the phenotype, proliferation, cytotoxic potential, and cytokine secretion of NK-cells [147,154,155] and decrease proliferation, differentiation, chemotactic properties of B-cells [156][157][158][159], acting over virtually all of the most important aspects of an immune response.…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Adenosine production: a common path for mesenchymal stem-cell and regulatory T-cell-mediated immunosuppression

Bravo

Carvalho

Saldanha-Araújo

2016

Purinergic Signalling

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Adenosine is an important molecule that exerts control on the immune system, by signaling through receptors lying on the surface of immune cells. This nucleotide is produced, in part, by the action of the ectoenzymes CD39 and CD73. Interestingly, these proteins are expressed on the cell surface of regulatory T-cells (Tregs) and mesenchymal stromal cells (MSCs)-two cell populations that have emerged as potential therapeutic tools in the field of cell therapy. In fact, the production of adenosine constitutes a mechanism used by both cell types to control the immune response. Recently, great scientific progress was obtained regarding the role of adenosine in the inflammatory environment. In this context, the present review focuses on the advances related to the impact of adenosine production over the immune modulatory activity of Tregs and MSCs, and how this nucleotide controls the biological functions of these cells. Finally, we mention the main challenges and hurdles to bring such molecule to clinical settings.

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“…However, the immunosuppressive activity of MSCs from various sources, and especially from bone marrow, on the T cells of both animals and humans, natural killer (NK) cells (Guo et al 2006 ;Spaggiari et al 2008 ) , and B cells (Comoli et al 2008 ) has been demonstrated. In studies aiming to explain the mechanisms of immunosuppressive activity of the MSCs, it has been declared that when the MSCs are co-cultured with T cells, dendritic cells (DCs), effector T cells, or NK cells, they change the cytokine secretion profi les of the related cells to encourage an antiinfl ammatory effect or a tolerant phenotype (Chang et al 2006 ) .…”

Section: Immunosuppressive and Immunomodulatory Properties Of Adult Smentioning

confidence: 99%

Mesenchymal Stem Cells: Possibilities of New Treatment Options

Tokcaer-Keskin

Koçak

Gürsel

et al. 2012

Adult and Embryonic Stem Cells

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Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation

Abstract: Our findings suggest that third-party MSC are able to suppress allo-specific antibody production in vitro, and may therefore help overcome a positive cross-match in sensitized transplant recipients.

Cited by 131 publications

References 25 publications

New advances in the mesenchymal stem cells therapy against skin flaps necrosis

New advances in the mesenchymal stem cells therapy against skin flaps necrosis

Adenosine production: a common path for mesenchymal stem-cell and regulatory T-cell-mediated immunosuppression

Mesenchymal Stem Cells: Possibilities of New Treatment Options

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