Human Male Genital Tract Immunity

Anderson, Deborah J.; Pudney, Jeffrey

doi:10.1016/b978-0-12-415847-4.00109-9

Cited by 4 publications

(2 citation statements)

References 138 publications

(130 reference statements)

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“…The presence of innate defense factors in the male reproductive tract has been much less well studied. However, several mucins are expressed, and lactoferrin, lysozyme, α-defensin HD-5, and secretory leukocyte protease inhibitor (SLPI) have been identified immunohistochemically in urethral epithelial cells and the glands of Littré (Table 1.1) (Anderson and Pudney 2015). HD-5 occurs mainly in an inactive precursor form in urethral secretions, where it is activated by proteases possibly derived from neutrophils during inflammation (Porter et al 2005).…”

Section: Innate Defense Factors In the Male Tractmentioning

confidence: 99%

See 1 more Smart Citation

Chlamydia Trachomatis Urogenital Infections

Armitage

Carey

Hickey

et al. 2018

Diagnostics to Pathogenomics of Sexually Transmitted Infections

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Quantitative evaluation of the cells involved in the immune system, such as lymphocytes, plasma cells, macrophages, dendritic cells, and epithelial cells, together with their products, including antibodies, cytokines, and humoral factors of innate immunity, convincingly revealed that the immune system associated with the mucosae is greater than its systemic counterpart (Russell et al. 2015a). This fact should not be surprising, as the development of the entire immune system during evolution and continuously in everyday life is driven by stimulation with commensal microbiota, antigens present in food and inhaled air, as well as pathogens throughout the enormous surface area of mucosal sites, which far exceeds the skin surface. The mucosal immune system comprises anatomically remote and physiologically distinct compartments that provide protection at various mucosal sites. Although the genital tract shares some common features with other mucosae, including the presence of humoral factors and cells of innate immunity, and the origin of cells involved in antibody production and T cell-mediated immunity, there are also many distinct features characteristic of the genital tract (Russell and Mestecky 2002, 2010; Mestecky et al. 2005). The spectrum of antigens including commensal or pathogenic microorganisms, and sperm is different from those at other mucosal sites. Furthermore, the primary physiological role of the genital tract is reproduction, which involves the acceptance of allogeneic sperm and semi-allogeneic offspring. This distinct physiological role influences the immune system of the genital tract with respect to the induction or suppression of immune responses, which must be considered in the development and application of vaccines against infectious agents of sexually transmitted diseases.

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Section: Innate Defense Factors In the Male Tractmentioning

confidence: 99%

“…In the human male genital tract tissues, Ig-producing cells are present in the penile urethra in glands of Littré with a predominance of IgA (Anderson and Pudney 2015). These cells are also positive for J chain and are localized in the vicinity of pIgR-positive columnar epithelial cells (Pudney and Anderson 1995).…”

Section: Immunoglobulin-producing Cellsmentioning

confidence: 99%