Mucosal Immunity in Sexually Transmitted Infections

Městecký, Jiří; Russell, Michael W.

doi:10.1002/9781119380924.ch1

Cited by 2 publications

(2 citation statements)

References 117 publications

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“…Likely, this is because murine nasal passages contain nasopharyngeal-associated lymphoid tissue ( 21 ), which has a tissue architecture akin to intestinal Peyer’s patches and is able to function as an inductive site that disseminates stimulated lymphocytes throughout the mucosal immune system, including salivary glands as well as the genital tract ( 13 , 28 ). In contrast, the genital tract does not contain inductive lymphoid tissue, typified by the presence of follicular T and B cell zones with an overlying follicle-associated epithelium containing M cells, and therefore is unable to disseminate responses to remote effector sites in the mucosal immune system ( 22 , 29 , 30 ). In addition, i.n.…”

Section: Discussionmentioning

confidence: 99%

Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae

Liu

Hammer

Daamen

et al. 2023

mSphere

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We previously demonstrated that female mice can be immunized intravaginally with gonococcal outer membrane vesicles (OMVs) plus microsphere (ms)-encapsulated interleukin-12 (IL-12 ms) to induce antigonococcal antibodies and resistance to genital tract challenge with live Neisseria gonorrhoeae . However, this route of vaccination may be impractical for human vaccine development and is inapplicable to males.

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Section: Discussionmentioning

confidence: 99%

Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae

Liu

Hammer

Daamen

et al. 2023

mSphere

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“…to infect and survive within macrophages and perpetuate the infection, with Chlamydia -infected urethral macrophages causing testicular infection in mice. 7 In addition to T-cells that consistently represent the predominant lymphocyte subtype in Chlamydia infection, 49 B-cells were present throughout the entire reproductive tract of both male and female koalas and highly correlated with the PCR load and the presence of the organisms. The role of B-cells and antibodies in Chlamydia infection is quite controversial.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical characterization of the immune cell response during chlamydial infection in the male and female koala (Phascolarctos cinereus) reproductive tract

Pagliarani,

Johnston,

Beagley

et al. 2024

Vet Pathol

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Chlamydiosis is one of the main causes of the progressive decline of koala populations in eastern Australia. While histologic, immunologic, and molecular studies have provided insights into the basic function of the koala immune system, the in situ immune cell signatures during chlamydial infection of the reproductive tract in koalas have not been investigated. Thirty-two female koalas and 47 males presented to wildlife hospitals with clinical signs suggestive of Chlamydia infection were euthanized with the entire reproductive tract collected for histology; immunohistochemistry (IHC) for T-cell (CD3ε, CD4, and CD8α), B-cell (CD79b), and human leukocyte antigen (HLA)-DR markers; and quantitative real-time polymerase chain reaction (rtPCR) for Chlamydia pecorum. T-cells, B-cells, and HLA-DR-positive cells were observed in both the lower and upper reproductive tracts of male and female koalas with a statistically significant associations between the degree of the inflammatory reaction; the number of CD3, CD4, CD79b, and HLA-DR positive cells; and the PCR load. CD4-positive cells were negatively associated with the severity of the gross lesions. The distribution of immune cells was also variable according to the location within the genital tract in both male and female koalas. These preliminary results represent a step forward towards further exploring mechanisms behind chlamydial infection immunopathogenesis, thus providing valuable information about the immune response and infectious diseases in free-ranging koalas.

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Mucosal Immunity in Sexually Transmitted Infections

Cited by 2 publications

References 117 publications

Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae

Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae

Immunohistochemical characterization of the immune cell response during chlamydial infection in the male and female koala (Phascolarctos cinereus) reproductive tract

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