Human Macula Investigated In Vivo with Polarization-Sensitive Optical Coherence Tomography

Pircher, Michael; Götzinger, Erich; Findl, Oliver; Michels, Stephan; Geitzenauer, W.; Leydolt, Christina; Schmidt‐Erfurth, Ursula; Hitzenberger, Christoph K.

doi:10.1167/iovs.05-1589

Cited by 146 publications

(125 citation statements)

References 37 publications

Supporting

Mentioning

123

Contrasting

Order By: Relevance

“…For example, loss of RNFL birefringence is observed during early stages of glaucoma, a leading cause of blindness in the developed world [8,9]. PS-OCT has found many applications, including anterior [10][11][12][13] and posterior eye imaging [13][14][15][16], skin imaging [17][18][19][20], burn depth and thermal damage assessment [21][22][23][24], dental imaging [25,26] and atherosclerotic plaque characterization [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Depth-encoded all-fiber swept source polarization sensitive OCT

Wang

Lee

Ahsen

et al. 2014

Biomed. Opt. Express

View full text Add to dashboard Cite

Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of conventional OCT and can assess depth-resolved tissue birefringence in addition to intensity. Most existing PS-OCT systems are relatively complex and their clinical translation remains difficult. We present a simple and robust all-fiber PS-OCT system based on swept source technology and polarization depth-encoding. Polarization multiplexing was achieved using a polarization maintaining fiber. Polarization sensitive signals were detected using fiber based polarization beam splitters and polarization controllers were used to remove the polarization ambiguity. A simplified post-processing algorithm was proposed for speckle noise reduction relaxing the demand for phase stability. We demonstrated systems design for both ophthalmic and catheter-based PS-OCT. For ophthalmic imaging, we used an optical clock frequency doubling method to extend the imaging range of a commercially available short cavity light source to improve polarization depth-encoding. For catheter based imaging, we demonstrated 200 kHz PS-OCT imaging using a MEMS-tunable vertical cavity surface emitting laser (VCSEL) and a high speed micromotor imaging catheter. The system was demonstrated in human retina, finger and lip imaging, as well as ex vivo swine esophagus and cardiovascular imaging. The all-fiber PS-OCT is easier to implement and maintain compared to previous PS-OCT systems and can be more easily translated to clinical applications due to its robust design. Aretz, E. F. Halpern, and B. E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111(12), 1551-1555 (2005).

show abstract

Section: Introductionmentioning

confidence: 99%

Depth-encoded all-fiber swept source polarization sensitive OCT

Wang

Lee

Ahsen

et al. 2014

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…Polarization-sensitive OCT (PS-OCT), which is one of the functional extensions of OCT, can improve the image contrast of OCT by imaging birefringence of biological fibrous tissues [4]. PS-OCT has been demonstrated to discriminate between ocular tissues using their birefringence properties in studies on the posterior segment of the eye, retinal nerve fiber [5,6] and scar tissue in age-related macular degeneration [7,8]. Simultaneous polarization scrambling measurements discriminated the retinal pigment epithelium from other structures [7,9].…”

Section: Introductionmentioning

confidence: 99%

“…PS-OCT has been demonstrated to discriminate between ocular tissues using their birefringence properties in studies on the posterior segment of the eye, retinal nerve fiber [5,6] and scar tissue in age-related macular degeneration [7,8]. Simultaneous polarization scrambling measurements discriminated the retinal pigment epithelium from other structures [7,9]. In the anterior eye segment, birefringence of trabecular meshwork and sclera has been used to discriminate individual tissues [10].…”

Section: Introductionmentioning

confidence: 99%

Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography

Lim

Yamanari

Fukuda

et al. 2011

Biomed. Opt. Express

View full text Add to dashboard Cite

Abstract:We present a case series of cornea and anterior segment disorders investigated by an office-based polarization-sensitive optical coherence tomography (PS-OCT). Blebs of glaucoma patients treated by trabeculectomy, and corneas of keratoconus and keratoplasty patients were measured by PS-OCT. Birefringence formations in trabeculectomy bleb were measured in 1 control eye and 3 eyes of trabeculectomy model rabbits. Polarization insensitive scattering OCT and the depth-resolved birefringence were measured simultaneously by PS-OCT. Abnormal birefringence was observed in keratoconus cases with advanced thinning and with a rupture of Descemet's membrane. The graft-host interface of the keratoplasty case showed abnormal birefringence. The appearance of abnormal birefringence in the cornea was likely to be an indication of crosslinking of collagen fibrils. The measurement of rabbit showed abnormal birefringence in the scarring eyes. Wide regions of strong birefringence were observed in the eyes of trabeculectomy patients who had high intraocular pressure. Visualization of scarring in bleb by PS-OCT may be useful for the planning of secondary surgery. PS-OCT showed promising for the study and diagnosis diseases related to abnormal fibrous tissues of the cornea and anterior eye segment.

show abstract

“…Mueller matrix methods are often used to reconstruct polarization parameters [42,43]. Depending on generator and analyzer configuration, PS-OCT can be used for simultaneous depthresolved determination of reflectivity, retardation, slow axis orientation, and relative attenuation [44][45][46][47][48]. Problems with this approach include speckle noise, inaccuracy in refractive index estimates, and high cost.…”

Section: 4: Experimental Methods For Ocular Polarization Interactionsmentioning

confidence: 99%

GDx-MM: An Imaging Mueller Matrix Retinal Polarimeter

Twietmeyer

2007

Frontiers in Optics 2007/Laser Science XXIII/Organic Materials and Devices for Displays and Energy Conversion

View full text Add to dashboard Cite

Human Macula Investigated In Vivo with Polarization-Sensitive Optical Coherence Tomography

Abstract: PS-OCT represents a powerful tool for increasing image contrast in ocular tissues. The observed polarization-scrambling nature of the RPE may be used in diseased eyes to locate the RPE or remains of the RPE definitively in OCT images.

Cited by 146 publications

References 37 publications

Depth-encoded all-fiber swept source polarization sensitive OCT

Depth-encoded all-fiber swept source polarization sensitive OCT

Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography

GDx-MM: An Imaging Mueller Matrix Retinal Polarimeter

Contact Info

Product

Resources

About