Human Lymphokine-Activated Killer Cells Augment Immunotherapy of Human Colon Carcinoma Xenografts with Monoclonal Antibody D612

Tumor targeting with radiolabeled antibodies in a human carcinoembryonic antigen transgenic mouse model

“…This model has been useful for demonstrating specific localization of antibodies in tumors (Ghose et al, 1981), for examining various factors that influence antibody uptake (Shockley et al, 1992) and for determining the therapeutic properties of unconjugated or conjugated antibodies (Pendurthi et al, 1991). However, some elements of the athymic nude mouse model have limited its utility or necessitated further manipulations in order to carry out specific types of experiments.…”