Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics

Capri, Miriam; Salvioli, Stefano; Monti, Daniela; Caruso, Calogero; Candore, Giuseppina; Vasto, Sonya; Olivieri, Fabiola; Marchegiani, Francesca; Sansoni, Paolo; Baggio, Giovannella; Mari, Daniela; Passarino, Giuseppe; Benedictis, G. De; Franceschi, Claudio

doi:10.1016/j.exger.2007.06.004

Cited by 57 publications

(46 citation statements)

References 61 publications

(60 reference statements)

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“…We regard this result as very important, particularly in relation to the many results recently obtained in genetics. All the data collected in this and other studies suggest that, as well as a variety of nuclear DNA polymorphisms (Di Bona et al 2009;Gravina et al 2009;Invidia et al 2010;Lescai, Marchegiani, and Franceschi 2009;Salvioli et al 2006;Testa et al 2009), maternally inherited mitochondrial DNA variants (Capri et al 2008;Raule et al 2007;Rose et al 2007;Rose et al 2010;Santoro et al 2006) contribute substantially to human longevity too.…”

Section: Some Preliminary Resultsmentioning

confidence: 55%

Demographic characteristics of Sardinian centenarian genealogies: Preliminary results of the AKeA2 study

Lipsi¹,

Caselli²,

Pozzi³

et al. 2015

DemRes

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Section: Some Preliminary Resultsmentioning

confidence: 55%

Demographic characteristics of Sardinian centenarian genealogies: Preliminary results of the AKeA2 study

Lipsi¹,

Caselli²,

Pozzi³

et al. 2015

DemRes

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“…These diseases appear to be correlated, leading to the concept of an age-related disease, which may be linked by the process of inflammation. So, genes involved in the regulatory pattern of inflammation should play a role in human ageing, furthermore high serological levels of pro-inflammatory mediators like cytokines and C reactive protein seem to be the marker of unsuccessful ageing [6,7,24].…”

Section: Age-related Diseases and Therapeuticsmentioning

confidence: 99%

“…Even if centenarians have an increased level of inflammatory mediators in comparison to old subjects and they are very frail, inflammageing is compatible with longevity (100 years of age or more); this paradox may be explained because centenarians have also high level of antiinflammatory cytokines and the protective genotype of important molecules (such as those belonging to natural immunity) [24], (see also below). Therefore, the most proper approach to tackle and manage inflammageing is to follow a sort of "mirror-strategy": since inflammageing is a pleiotropic process where many different factors operate, in the same way pleiotropic interventions acting on different targets and at different levels at the same time are to be preferred and chosen, in a kind of mimic way [25].…”

Section: Age-related Diseases and Therapeuticsmentioning

confidence: 99%

“…The data on the determinants of human longevity indicate that centenarians are a good choice for the study of longevity, because they represent an extreme phenotype, i.e., the survival tail of the population who escaped neonatal mortality, pre-antibiotic era illnesses, and fatal outcomes of age-related complex diseases. Centenarians are quite capable of mounting effective inflammatory responses; however, inflammatory status, correlated to increasing risk of developing frailty and diseases, is compensated by the concomitant development of strong and effective anti-inflammatory responses [24,25,105]; (see also above). Hence, the study of centenarians allows us to correlate longevity and some of the major age-related pathologies.…”

Section: Longevitymentioning

confidence: 99%

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Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement

Candore

Caruso

Jirillo³

et al. 2010

CPD

123

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Nowadays, people are living much longer than they used to do, however they are not free from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and individuals, is a post-maturational process that, due to a diminished homeostasis and increased organism frailty, causes a reduction of the response to environmental stimuli and, in general, is associated to an increased predisposition to illness and death. However, the high incidence of death due to infectious, cardiovascular and cancer diseases underlies a common feature in these pathologies that is represented by dysregulation of both instructive and innate immunity. Several studies show that a low-grade systemic inflammation characterizes ageing and that inflammatory markers are significant predictors of mortality in old humans. This pro-inflammatory status of the elderly underlies biological mechanisms responsible for physical function decline and agerelated diseases such as Alzheimer's disease and atherosclerosis are initiated or worsened by systemic inflammation. Understanding of the ageing process should have a prominent role in new strategies for extending the health old population. Accordingly, as extensively discussed in the review and in the accompanying related papers, investigating ageing pathophysiology, particularly disentangling agerelated low grade inflammation, is likely to provide important clues about how to develop drugs that can slow or delay ageing.

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“…Both of these genes and the majority of other potential findings that have emerged during the past decade (de Magalhães et al 2009a, b;Capri et al 2006Capri et al , 2008Pawlikowska et al 2009;Bonafè and Olivieri 2009;Singh et al 2007) are related mainly to inflammation, stress response or lipid and glucose metabolism.…”

Section: Introductionmentioning

confidence: 96%

Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes

Spazzafumo

Olivieri

Abbatecola

et al. 2011

AGE

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Factor structure analyses have revealed the presence of specific biological system markers in healthy humans and diseases. However, this type of approach in very old persons and in type 2 diabetes (T2DM) is lacking. A total sample of 2,137 Italians consisted of two groups: 1,604 healthy and 533 with T2DM. Age (years) was categorized as adults (≤65), old (66-85), oldest old (>85-98) and centenarians (≥99). Specific biomarkers of routine haematological and biochemical testing were tested across each age group. Exploratory factorial analysis (EFA) by principal component method with Varimax rotation was used to identify factors including related variables. Structural equation modelling (SEM) was applied to confirm factor solutions for each age group. EFA and SEM identified specific factor structures according to age in both groups. An age-associated reduction of factor structure was observed from adults to oldest old in the healthy group (explained variance 60.4% vs 50.3%) and from adults to old in the T2DM group AGE

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Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics

Cited by 57 publications

References 61 publications

Demographic characteristics of Sardinian centenarian genealogies: Preliminary results of the AKeA2 study

Demographic characteristics of Sardinian centenarian genealogies: Preliminary results of the AKeA2 study

Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement

Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes

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