Human Leukocyte Antigen (HLA) Typing in Medically Assisted Reproduction

Salih, Sana M.; Havemann, Logan M.; Lindheim, Steven R.

doi:10.1007/978-981-15-2377-9_34

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Clinical Significance In Reproductive Medicine1

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2023

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“…These can be addressed by the characterization of the HLA and KIR or its receptor KIR genotyping [ 199 ]. Certain HLA and their pregnancy-relevant receptor types are found to be associated with poor IVF outcomes, including disturbances in implantation, the formation of the placenta, or the maintenance of the pregnancy [ 200 ]. However, the significance is limited, and further research is necessary.…”

Section: Clinical Significance In Reproductive Medicinementioning

confidence: 99%

Immune Cell Functionality during Decidualization and Potential Clinical Application

Stope

Mustea

Sänger

et al. 2023

Life

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Due to a vast influx in the secretory phase of the menstrual cycle, leukocytes represent 40–50% of the decidua at the time of implantation. Their importance for the implantation, maintenance of pregnancy, and parturition are known yet not fully understood. Thus, in idiopathic infertility, decidual immune-related factors are speculated to be the cause. In this review, the immune cell functions in the decidua were summarized, and clinical diagnostics, as well as interventions, were discussed. There is a rising number of commercially available diagnostic tools. However, the intervention options are still limited and/or poorly studied. In order for us to make big steps towards the proper use of reproductive immunology findings, we need to understand the mechanisms and especially support translational research.

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Section: Clinical Significance In Reproductive Medicinementioning

confidence: 99%