Human infections due to Schizophyllum commune: Case report and review of the literature

Cavanna, C.; Pagella, Fabio; Esposto, Maria Carmela; Tamarozzi, Francesca; Clemente, Libera; Marone, Piero; Matti, Elina; Lallitto, Fabiola

doi:10.1016/j.mycmed.2019.100897

Cited by 9 publications

(12 citation statements)

References 18 publications

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“…S. commune is a basidiomycete characterized by the formation of clamp connections, hyphal spicules, and basidiocarps with basidiospores [ 8 ]. The fungus is an opportunistic pathogen that can cause a wide range of clinical manifestations, including sinusitis, allergic bronchopulmonary mycosis, eye, ear, and skin infections, abscesses, and fungemia; however, human infections are rarely reported [ 1 ]. According to a previous worldwide study of the 71 cases of S. commune reported, 45 (63%) were bronchopulmonary and 22 (31%) were sinusitis [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…S. commune is cultured according to a routine laboratory culture method as described in our case. Identification based solely on macro-microscopic characteristics of cultured colonies is challenging in practice because S. commune generally does not form spores and grows woolly, whitish, and sterile colonies [ 1 ]. Long incubation times are required for its characteristic macroscopic structures to develop, making cultured colonies impractical for clinical diagnosis [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Identification based solely on macro-microscopic characteristics of cultured colonies is challenging in practice because S. commune generally does not form spores and grows woolly, whitish, and sterile colonies [ 1 ]. Long incubation times are required for its characteristic macroscopic structures to develop, making cultured colonies impractical for clinical diagnosis [ 1 ]. Since the reference spectral library of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is still incomplete, timely use of molecular techniques should be considered the gold standard for diagnosing S. commune in clinically suspicious cases [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Schizophyllum commune is an environmental basidiomycete that is widely distributed in nature and grows well on rotting wood and other plants [ 1 ]. It belongs to the phylum Basidiomycota, subphylum Agaricomycotina, and order Agaricales, which includes the fungi called mushrooms [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Schizophyllum commune is rarely involved in human disease, but it is the most common basidiomycete among the filamentous fungi to cause infections in humans [ 1 ]. This fungus causes a wide range of clinical manifestations, from allergic reactions to invasive infections, but it is primarily responsible for infections of the respiratory system.…”

Section: Introductionmentioning

confidence: 99%

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A Schizophyllum commune fungus ball in a lung cancer cavity: a case report

et al. 2021

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Background Schizophyllum commune is a basidiomycete that lives in the environment and can cause infections, mainly those of the respiratory system. Although S. commune is increasingly reported as a cause of allergic bronchopulmonary mycosis and sinusitis, cases of fungal ball formation are extremely uncommon. Identification of S. commune is difficult using routine mycological diagnostic methods, and in clinically suspicious cases, internal transcribed spacer sequencing should be used for diagnosis. Here, we report a first case of lung cancer with a fungal ball formation of S. commune, confirmed by analyzing the internal transcribed spacer. Case presentation A 76-year-old man with diabetes and hypertension was admitted to the hospital with a chief complaint of hemosputum, which he had for about 19 months. A computed tomography image of the patient’s chest showed a cavity and internal nodule in the left upper lobe of his lung. A left upper lobectomy was performed, and histopathological examination revealed squamous cell carcinoma of the lung and a fungal ball. The isolate from the surgical specimen was identified as S. commune by analyzing the internal transcribed spacer. The patient had no recurrence of the infection during 5 months of follow-up. Conclusions Only three cases of lung fungal balls caused by S. commune have been previously reported, and this is the first case of lung cancer cavity with a fungal ball formation. In cases of fungal ball formation in the lung, S. commune should be considered a possible causative microorganism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Schizophyllum commune fungus ball in a lung cancer cavity: a case report

et al. 2021

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References

2023

Larone's Medically Important Fungi

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Marine Fungal Diversity and Dynamics in the Gulf of Trieste (Northern Adriatic Sea)

Banchi,

Manna,

Muggia

et al. 2024

Microb Ecol

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Fungi contribute to different important ecological processes, including decomposition of organic matter and nutrient cycling, but in the marine environment the main factors influencing their diversity and dynamics at the spatial and temporal levels are still largely unclear. In this study, we performed DNA metabarcoding on seawater sampled monthly over a year and a half in the Gulf of Trieste (northern Adriatic Sea), targeting the internal transcribed spacer (ITS) and the 18S rRNA gene regions. The fungal communities were diverse, very dynamic, and belonged predominantly to marine taxa. Samples could be clustered in two groups, mainly based on the high (> 30%) or low relative proportion of the ascomycetes Parengyodontium album, which emerged as a key taxon in this area. Dissolved and particulate organic C:N ratio played important roles in shaping the mycoplankton assemblages, suggesting that differently bioavailable organic matter pools may be utilized by different consortia. The proportion of fungal over total reads was 31% for ITS and 0.7% for 18S. ITS had the highest taxonomic resolution but low power to detect early divergent fungal lineages. Our results on composition, distribution, and environmental drivers extended our knowledge of the structure and function of the mycobiome of coastal waters.

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Human infections due to Schizophyllum commune: Case report and review of the literature

Cited by 9 publications

References 18 publications

A Schizophyllum commune fungus ball in a lung cancer cavity: a case report

A Schizophyllum commune fungus ball in a lung cancer cavity: a case report

References

Marine Fungal Diversity and Dynamics in the Gulf of Trieste (Northern Adriatic Sea)

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