Human infection with a novel, highly pathogenic avian influenza A (H5N6) virus: Virological and clinical findings

Pan, Ming; Gao, Rongbao; Lv, Qiang; Huang, Shunhe; Zhou, Z.; Yang, Lei; Li, Xiaodan; Zhao, Xiang; Zou, Xiaohui; Tong, Wenbin; Mao, Suling; Zou, Shumei; Bo, Hong; Zhu, Xiaoping; Liu, Lei; Hu, Yuan; Zhang, Minghong; Wang, Daqing; Li, Zumao; Zhao, Wei; Ma, Maoli; Li, Yaqiang; Li, Tianshu; Yang, Huiping; Xu, Jianan; Zhou, Ling; Zhou, Xingyu; Tang, Wei; Song, Ying; Chen, Tao; Bai, Tian; Zhou, Jianfang; Wang, Dayang; Wu, Guizhen; Li, Dexin; Feng, Zijian; Gao, George F.; Wang, Yu; He, Shusen; Shu, Yuelong

doi:10.1016/j.jinf.2015.06.009

Cited by 158 publications

(129 citation statements)

References 25 publications

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“…, A(H7N9) , A(H10N8) and A (H5N6) viruses (Pan et al, 2016), and the 2009 pandemic influenza virus A(H1N1)pdm09 with D222G substitution (Cheng et al, 2012). Influenza B virus infection also has similar clinical characteristics and severity as seasonal influenza A virus infection (Su et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans

Mok

Chan

et al. 2016

Journal of General Virology

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Section: Introductionmentioning

confidence: 99%

Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans

Mok

Chan

et al. 2016

Journal of General Virology

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“…Recently, we reported that the increased H5N6 virus positivity rate in the live-poultry markets coincided with subsequent human infections in Shenzhen in China (47). Human infections with HPAI H5N6 viruses resulted in high mortality rates (10/14) and clinical symptoms similar to those seen in HPAI H5N1 patients (9,48). Therefore, H5N6 viruses pose a significant public health threat, which requires close monitoring similar to that for HPAI H5N1 viruses.…”

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confidence: 98%

“…During the same period in East Asia, where the 2.3.4.4 clade virus originated, wide outbreaks of HPAI H5N8, H5N6, and H5N2 were reported (http://www.oie.int/). In April 2014, the first fatal human case of HPAI H5N6 virus infection was identified in China (9). Up to 8 June 2016, a total of 14 H5N6 cases had been reported in China (http://www.who.int/en/), raising the threat of this viral infection to public health.…”

mentioning

confidence: 99%

“…It is important to understand the origins and genesis of these subtype viruses and to determine their relationships with other subtype viruses in this clade. Previous studies revealed that the HPAI H5N6 virus contained the hemagglutinin (HA) gene of H5 clade 2.3.4.4, the internal genes of H5 clade 2.3.2.1, and the NA gene from the H6N6 avian virus (9,12,13). Based on the genetic evidence, HPAI H5N6 virus likely originated from migratory waterfowl (14).…”

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confidence: 99%

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Genesis and Dissemination of Highly Pathogenic H5N6 Avian Influenza Viruses

Yang

Zhu

et al. 2017

J Virol

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“…Subsequently, three more human infections with H5N6 virus cases were reported in the winter of 2014-2015 (2,3). Between 30 December 2015 and 2 January 2016, the NHFPC notified the World Health Organization of two additional human cases of avian H5N6 virus infection.…”

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confidence: 99%

Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets

Sun

Wei

et al. 2016

J Virol

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Since May 2014, highly pathogenic avian influenza H5N6 virus has been reported to cause six severe human infections three of which were fatal. The biological properties of this subtype, in particular its relative pathogenicity and transmissibility in mammals, are not known. We characterized the virus receptor-binding affinity, pathogenicity, and transmissibility in mice and ferrets of four H5N6 isolates derived from waterfowl in China from 2013-2014. All four H5N6 viruses have acquired a binding affinity for human-like SA␣2,6Gal-linked receptor to be able to attach to human tracheal epithelial and alveolar cells. The emergent H5N6 viruses, which share high sequence similarity with the human isolate A/Guangzhou/39715/2014 (H5N6), were fully infective and highly transmissible by direct contact in ferrets but showed less-severe pathogenicity than the parental H5N1 virus. The present results highlight the threat of emergent H5N6 viruses to poultry and human health and the need to closely track their continual adaptation in humans. O n 7 May 2014, the Chinese National Health and Family Planning Commission (NHFPC) announced the first human case of avian H5N6 influenza virus infection (1). Subsequently, three more human infections with H5N6 virus cases were reported in the winter of 2014-2015 (2, 3). Between 30 December 2015 and 2 January 2016, the NHFPC notified the World Health Organization of two additional human cases of avian H5N6 virus infection. All six human infections were presented as acute respiratory distress syndrome (ARDS) of which three were fatal. Five cases had a common history of contact with or exposure to poultry or livebird markets before disease onset (1-3), suggesting zoonotic transmission. Sequence analyses of the human H5N6 isolates indicated that the virus was derived from clade 2.3.4.4 avian H5N6 viruses that are circulating in poultry in China (1, 2, 4). Avian H5N6 influenza virus was first isolated from mallards in North America in 1975 (5). In China, H5N6 virus first emerged in 2010 and has since been extensively circulating in both domestic and wild birds (6-9). Recent surveillance data from the Ministry of Agriculture of China indicate that H5N6 viruses have become enzootic in domestic poultry. Unlike the worldwide distribution H5N2 and H5N8 viruses (10-12), prevailing H5N6 viruses appear to be largely confined to China and Laos (13). We recently characterized the novel H5N6 viruses in poultry (14); however, their zoonotic capability and characteristics are poorly understood. In the present study, we examined the emergent H5N6 virus for its genetic characteristics, receptor binding properties, pathogenicity, and transmissibility in mice and ferrets. MATERIALS AND METHODS Ethical

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Human infection with a novel, highly pathogenic avian influenza A (H5N6) virus: Virological and clinical findings

Cited by 158 publications

References 25 publications

Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans

Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans

Genesis and Dissemination of Highly Pathogenic H5N6 Avian Influenza Viruses

Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets

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